TM2D2 protein (Homo sapiens) - STRING network view

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Score

TM2D2

TM2 domain containing 2 (214 aa)

Predicted Functional Partners:

TM2D1

0.910

WHSC1L1

0.652

PHF12

0.613

PROSC

0.550

LMLN

0.548

CALN1

0.509

EPN2

0.491

ASH2L

0.489

ADAM32

0.470

ZNF703

0.457

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM32	TM2D2	ENSP00000369238	ENSP00000416050	ADAM metallopeptidase domain 32; May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein (By similarity)	TM2 domain containing 2	0.470
ASH2L	PROSC	ENSP00000340896	ENSP00000333551	ash2 (absent, small, or homeotic)-like (Drosophila); Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates ’Lys-4’ of histone H3, but not if the neighboring ’Lys-9’ residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ’Lys-4’ of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis	proline synthetase co-transcribed homolog (bacterial)	0.501
ASH2L	TM2D2	ENSP00000340896	ENSP00000416050	ash2 (absent, small, or homeotic)-like (Drosophila); Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates ’Lys-4’ of histone H3, but not if the neighboring ’Lys-9’ residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ’Lys-4’ of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis	TM2 domain containing 2	0.489
ASH2L	WHSC1L1	ENSP00000340896	ENSP00000313983	ash2 (absent, small, or homeotic)-like (Drosophila); Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates ’Lys-4’ of histone H3, but not if the neighboring ’Lys-9’ residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ’Lys-4’ of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis	Wolf-Hirschhorn syndrome candidate 1-like 1	0.628
CALN1	EPN2	ENSP00000378690	ENSP00000320543	calneuron 1; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning	epsin 2; Plays a role in the formation of clathrin-coated invaginations and endocytosis	0.417
CALN1	TM2D2	ENSP00000378690	ENSP00000416050	calneuron 1; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning	TM2 domain containing 2	0.509
EPN2	CALN1	ENSP00000320543	ENSP00000378690	epsin 2; Plays a role in the formation of clathrin-coated invaginations and endocytosis	calneuron 1; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning	0.417
EPN2	TM2D2	ENSP00000320543	ENSP00000416050	epsin 2; Plays a role in the formation of clathrin-coated invaginations and endocytosis	TM2 domain containing 2	0.491
LMLN	TM2D2	ENSP00000410926	ENSP00000416050	leishmanolysin-like (metallopeptidase M8 family); Metalloprotease essential for the coordination of mitotic progression, and also plays a role in cell migration (By similarity)	TM2 domain containing 2	0.548
PHF12	TM2D2	ENSP00000329933	ENSP00000416050	PHD finger protein 12; Acts as a transcriptional repressor. Involved in recruitment of functional SIN3A complexes to DNA. Represses transcription at least in part through the activity of an associated histone deacetylase (HDAC). May also repress transcription in a SIN3A-independent manner through recruitment of functional AES complexes to DNA	TM2 domain containing 2	0.613
PROSC	ASH2L	ENSP00000333551	ENSP00000340896	proline synthetase co-transcribed homolog (bacterial)	ash2 (absent, small, or homeotic)-like (Drosophila); Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates ’Lys-4’ of histone H3, but not if the neighboring ’Lys-9’ residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ’Lys-4’ of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis	0.501
PROSC	TM2D2	ENSP00000333551	ENSP00000416050	proline synthetase co-transcribed homolog (bacterial)	TM2 domain containing 2	0.550
PROSC	WHSC1L1	ENSP00000333551	ENSP00000313983	proline synthetase co-transcribed homolog (bacterial)	Wolf-Hirschhorn syndrome candidate 1-like 1	0.677
PROSC	ZNF703	ENSP00000333551	ENSP00000332325	proline synthetase co-transcribed homolog (bacterial)	zinc finger protein 703; Transcriptional corepressor which does not bind directly to DNA and may regulate transcription through recruitment of histone deacetylases to gene promoters. Regulates cell adhesion, migration and proliferation. May be required for segmental gene expression during hindbrain development	0.581
TM2D1	TM2D2	ENSP00000360222	ENSP00000416050	TM2 domain containing 1; May participate in beta-amyloid-induced apoptosis via its interaction with beta-APP42	TM2 domain containing 2	0.910
TM2D2	ADAM32	ENSP00000416050	ENSP00000369238	TM2 domain containing 2	ADAM metallopeptidase domain 32; May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein (By similarity)	0.470
TM2D2	ASH2L	ENSP00000416050	ENSP00000340896	TM2 domain containing 2	ash2 (absent, small, or homeotic)-like (Drosophila); Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates ’Lys-4’ of histone H3, but not if the neighboring ’Lys-9’ residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at ’Lys-4’ of histone H3. May function as a transcriptional regulator. May play a role in hematopoiesis	0.489
TM2D2	CALN1	ENSP00000416050	ENSP00000378690	TM2 domain containing 2	calneuron 1; Negatively regulates Golgi-to-plasma membrane trafficking by interacting with PI4KB and inhibiting its activity (By similarity). May play a role in the physiology of neurons and is potentially important in memory and learning	0.509
TM2D2	EPN2	ENSP00000416050	ENSP00000320543	TM2 domain containing 2	epsin 2; Plays a role in the formation of clathrin-coated invaginations and endocytosis	0.491
TM2D2	LMLN	ENSP00000416050	ENSP00000410926	TM2 domain containing 2	leishmanolysin-like (metallopeptidase M8 family); Metalloprotease essential for the coordination of mitotic progression, and also plays a role in cell migration (By similarity)	0.548

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