CFB protein (Homo sapiens) - STRING network view

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Score

CFB

complement factor B (764 aa)

Predicted Functional Partners:

C3

0.990

CFP

0.892

GNB2L1

0.810

NISCH

0.808

MMP13

0.733

ARMS2

0.723

SNAI1

0.716

RUNX2

0.709

RUNX3

0.698

C4B

0.695

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARMS2	C3	ENSP00000436682	ENSP00000245907	age-related maculopathy susceptibility 2	complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates	0.468
ARMS2	CFB	ENSP00000436682	ENSP00000416561	age-related maculopathy susceptibility 2	complement factor B	0.723
C3	ARMS2	ENSP00000245907	ENSP00000436682	complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates	age-related maculopathy susceptibility 2	0.468
C3	C4B	ENSP00000245907	ENSP00000415941	complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates	complement component 4B (Chido blood group)	0.849
C3	CFB	ENSP00000245907	ENSP00000416561	complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates	complement factor B	0.990
C3	CFP	ENSP00000245907	ENSP00000247153	complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates	complement factor properdin; A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes	0.992
C4B	C3	ENSP00000415941	ENSP00000245907	complement component 4B (Chido blood group)	complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates	0.849
C4B	CFB	ENSP00000415941	ENSP00000416561	complement component 4B (Chido blood group)	complement factor B	0.695
C4B	CFP	ENSP00000415941	ENSP00000247153	complement component 4B (Chido blood group)	complement factor properdin; A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes	0.700
CFB	ARMS2	ENSP00000416561	ENSP00000436682	complement factor B	age-related maculopathy susceptibility 2	0.723
CFB	C3	ENSP00000416561	ENSP00000245907	complement factor B	complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates	0.990
CFB	C4B	ENSP00000416561	ENSP00000415941	complement factor B	complement component 4B (Chido blood group)	0.695
CFB	CFP	ENSP00000416561	ENSP00000247153	complement factor B	complement factor properdin; A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes	0.892
CFB	GNB2L1	ENSP00000416561	ENSP00000426909	complement factor B	guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1	0.810
CFB	MMP13	ENSP00000416561	ENSP00000260302	complement factor B	matrix metallopeptidase 13 (collagenase 3); Degrades collagen type I. Does not act on gelatin or casein. Could have a role in tumoral process	0.733
CFB	NISCH	ENSP00000416561	ENSP00000339958	complement factor B	nischarin	0.808
CFB	RUNX2	ENSP00000416561	ENSP00000360493	complement factor B	runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5’- PYGPYGGT-3’, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. In osteoblasts, supports transcription activation- synergizes with SPEN/MINT to enhance FGFR2-media [...]	0.709
CFB	RUNX3	ENSP00000416561	ENSP00000343477	complement factor B	runt-related transcription factor 3; CBF binds to the core site, 5’-PYGPYGGT-3’, of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters	0.698
CFB	SNAI1	ENSP00000416561	ENSP00000244050	complement factor B	snail homolog 1 (Drosophila); Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up- regulation of CDKN2B, possibly by binding to the CD [...]	0.716
CFP	C3	ENSP00000247153	ENSP00000245907	complement factor properdin; A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes	complement component 3; C3 plays a central role in the activation of the complement system. Its processing by C3 convertase is the central reaction in both classical and alternative complement pathways. After activation C3b can bind covalently, via its reactive thioester, to cell surface carbohydrates or immune aggregates	0.992

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