node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IFNG | SLC15A2 | ENSP00000229135 | ENSP00000417085 | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | solute carrier family 15 (H+/peptide transporter), member 2; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides | 0.649 |
PDZD3 | SLC15A2 | ENSP00000347742 | ENSP00000417085 | PDZ domain containing 3; Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions | solute carrier family 15 (H+/peptide transporter), member 2; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides | 0.605 |
PDZD3 | SLC22A5 | ENSP00000347742 | ENSP00000245407 | PDZ domain containing 3; Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions | solute carrier family 22 (organic cation/carnitine transporter), member 5; Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3 | 0.684 |
PDZD3 | SLCO1A2 | ENSP00000347742 | ENSP00000305974 | PDZ domain containing 3; Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions | solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin | 0.529 |
PDZK1 | SLC15A2 | ENSP00000342143 | ENSP00000417085 | PDZ domain containing 1 | solute carrier family 15 (H+/peptide transporter), member 2; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides | 0.740 |
PDZK1 | SLC22A5 | ENSP00000342143 | ENSP00000245407 | PDZ domain containing 1 | solute carrier family 22 (organic cation/carnitine transporter), member 5; Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3 | 0.943 |
PDZK1 | SLC22A6 | ENSP00000342143 | ENSP00000367102 | PDZ domain containing 1 | solute carrier family 22 (organic anion transporter), member 6 | 0.467 |
PDZK1 | SLC22A8 | ENSP00000342143 | ENSP00000337335 | PDZ domain containing 1 | solute carrier family 22 (organic anion transporter), member 8; Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA) | 0.444 |
SLC15A2 | IFNG | ENSP00000417085 | ENSP00000229135 | solute carrier family 15 (H+/peptide transporter), member 2; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides | interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity) | 0.649 |
SLC15A2 | PDZD3 | ENSP00000417085 | ENSP00000347742 | solute carrier family 15 (H+/peptide transporter), member 2; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides | PDZ domain containing 3; Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions | 0.605 |
SLC15A2 | PDZK1 | ENSP00000417085 | ENSP00000342143 | solute carrier family 15 (H+/peptide transporter), member 2; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides | PDZ domain containing 1 | 0.740 |
SLC15A2 | SLC22A5 | ENSP00000417085 | ENSP00000245407 | solute carrier family 15 (H+/peptide transporter), member 2; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides | solute carrier family 22 (organic cation/carnitine transporter), member 5; Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3 | 0.656 |
SLC15A2 | SLC22A6 | ENSP00000417085 | ENSP00000367102 | solute carrier family 15 (H+/peptide transporter), member 2; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides | solute carrier family 22 (organic anion transporter), member 6 | 0.666 |
SLC15A2 | SLC22A7 | ENSP00000417085 | ENSP00000361666 | solute carrier family 15 (H+/peptide transporter), member 2; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides | solute carrier family 22 (organic anion transporter), member 7; Mediates sodium-independent multispecific organic anion transport. Transport of prostaglandin E2, prostaglandin F2, tetracycline, bumetanide, estrone sulfate, glutarate, dehydroepiandrosterone sulfate, allopurinol, 5-fluorouracil, paclitaxel, L-ascorbic acid, salicylate, ethotrexate, and alpha- ketoglutarate | 0.584 |
SLC15A2 | SLC22A8 | ENSP00000417085 | ENSP00000337335 | solute carrier family 15 (H+/peptide transporter), member 2; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides | solute carrier family 22 (organic anion transporter), member 8; Plays an important role in the excretion/detoxification of endogenous and exogenous organic anions, especially from the brain and kidney. Involved in the transport basolateral of steviol, fexofenadine. Transports benzylpenicillin (PCG), estrone- 3-sulfate (E1S), cimetidine (CMD), 2,4-dichloro-phenoxyacetate (2,4-D), p-amino-hippurate (PAH), acyclovir (ACV) and ochratoxin (OTA) | 0.662 |
SLC15A2 | SLC5A1 | ENSP00000417085 | ENSP00000266088 | solute carrier family 15 (H+/peptide transporter), member 2; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides | solute carrier family 5 (sodium/glucose cotransporter), member 1; Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2-1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules | 0.610 |
SLC15A2 | SLCO1A2 | ENSP00000417085 | ENSP00000305974 | solute carrier family 15 (H+/peptide transporter), member 2; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides | solute carrier organic anion transporter family, member 1A2; Mediates the Na(+)-independent transport of organic anions such as sulfobromophthalein (BSP) and conjugated (taurocholate) and unconjugated (cholate) bile acids (By similarity). Selectively inhibited by the grapefruit juice component naringin | 0.604 |
SLC15A2 | SLCO2B1 | ENSP00000417085 | ENSP00000289575 | solute carrier family 15 (H+/peptide transporter), member 2; Proton-coupled intake of oligopeptides of 2 to 4 amino acids with a preference for dipeptides | solute carrier organic anion transporter family, member 2B1; Mediates the Na(+)-independent transport of organic anions such as taurocholate, the prostaglandins PGD2, PGE1, PGE2, leukotriene C4, thromboxane B2 and iloprost (By similarity) | 0.587 |
SLC22A5 | PDZD3 | ENSP00000245407 | ENSP00000347742 | solute carrier family 22 (organic cation/carnitine transporter), member 5; Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3 | PDZ domain containing 3; Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation. Stimulates SLC9A3 activity in the presence of elevated calcium ions | 0.684 |
SLC22A5 | PDZK1 | ENSP00000245407 | ENSP00000342143 | solute carrier family 22 (organic cation/carnitine transporter), member 5; Sodium-ion dependent, high affinity carnitine transporter. Involved in the active cellular uptake of carnitine. Transports one sodium ion with one molecule of carnitine. Also transports organic cations such as tetraethylammonium (TEA) without the involvement of sodium. Also relative uptake activity ratio of carnitine to TEA is 11.3 | PDZ domain containing 1 | 0.943 |