node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FAM82A2 | VAPB | ENSP00000260385 | ENSP00000417175 | family with sequence similarity 82, member A2; Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis | VAMP (vesicle-associated membrane protein)-associated protein B and C; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation | 0.923 |
MPST | UBC | ENSP00000380318 | ENSP00000344818 | mercaptopyruvate sulfurtransferase; Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regu [...] | ubiquitin C | 0.795 |
MPST | VAPB | ENSP00000380318 | ENSP00000417175 | mercaptopyruvate sulfurtransferase; Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regu [...] | VAMP (vesicle-associated membrane protein)-associated protein B and C; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation | 0.964 |
OSBP | OSBPL9 | ENSP00000263847 | ENSP00000412733 | oxysterol binding protein; Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25- hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability | oxysterol binding protein-like 9 | 0.425 |
OSBP | UBC | ENSP00000263847 | ENSP00000344818 | oxysterol binding protein; Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25- hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability | ubiquitin C | 0.795 |
OSBP | VAPA | ENSP00000263847 | ENSP00000345656 | oxysterol binding protein; Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25- hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa; May play a role in vesicle trafficking | 0.999 |
OSBP | VAPB | ENSP00000263847 | ENSP00000417175 | oxysterol binding protein; Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25- hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability | VAMP (vesicle-associated membrane protein)-associated protein B and C; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation | 0.986 |
OSBPL9 | OSBP | ENSP00000412733 | ENSP00000263847 | oxysterol binding protein-like 9 | oxysterol binding protein; Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25- hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability | 0.425 |
OSBPL9 | UBC | ENSP00000412733 | ENSP00000344818 | oxysterol binding protein-like 9 | ubiquitin C | 0.680 |
OSBPL9 | VAPA | ENSP00000412733 | ENSP00000345656 | oxysterol binding protein-like 9 | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa; May play a role in vesicle trafficking | 0.948 |
OSBPL9 | VAPB | ENSP00000412733 | ENSP00000417175 | oxysterol binding protein-like 9 | VAMP (vesicle-associated membrane protein)-associated protein B and C; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation | 0.985 |
SCAF4 | UBC | ENSP00000286835 | ENSP00000344818 | SR-related CTD-associated factor 4; May act to physically and functionally link transcription and pre-mRNA processing (By similarity) | ubiquitin C | 0.804 |
SCAF4 | VAPB | ENSP00000286835 | ENSP00000417175 | SR-related CTD-associated factor 4; May act to physically and functionally link transcription and pre-mRNA processing (By similarity) | VAMP (vesicle-associated membrane protein)-associated protein B and C; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation | 0.967 |
TARDBP | UBC | ENSP00000240185 | ENSP00000344818 | TAR DNA binding protein | ubiquitin C | 0.999 |
TARDBP | VAPB | ENSP00000240185 | ENSP00000417175 | TAR DNA binding protein | VAMP (vesicle-associated membrane protein)-associated protein B and C; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation | 0.940 |
UBC | MPST | ENSP00000344818 | ENSP00000380318 | ubiquitin C | mercaptopyruvate sulfurtransferase; Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regu [...] | 0.795 |
UBC | OSBP | ENSP00000344818 | ENSP00000263847 | ubiquitin C | oxysterol binding protein; Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25- hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability | 0.795 |
UBC | OSBPL9 | ENSP00000344818 | ENSP00000412733 | ubiquitin C | oxysterol binding protein-like 9 | 0.680 |
UBC | SCAF4 | ENSP00000344818 | ENSP00000286835 | ubiquitin C | SR-related CTD-associated factor 4; May act to physically and functionally link transcription and pre-mRNA processing (By similarity) | 0.804 |
UBC | TARDBP | ENSP00000344818 | ENSP00000240185 | ubiquitin C | TAR DNA binding protein | 0.999 |