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FAM82A2 FAM82A2 YIF1A YIF1A OSBP OSBP VAPB VAPB VAPA VAPA OSBPL9 OSBPL9 MPST MPST UBC UBC ZFYVE27 ZFYVE27 TARDBP TARDBP SCAF4 SCAF4
"VAPB" - VAMP (vesicle-associated membrane protein)-associated protein B and C in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small nodes:
protein of unknown 3D structure
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large nodes:
some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
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from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
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textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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VAPBVAMP (vesicle-associated membrane protein)-associated protein B and C; Participates in the endoplasmic reticulum unfolded protein response (UPR) by inducing ERN1/IRE1 activity. Involved in cellular calcium homeostasis regulation (243 aa)    
Predicted Functional Partners:
VAPA
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa; May play a role in vesicle trafficking (294 aa)
        score_image score_image score_image score_image 0.991
OSBP
oxysterol binding protein; Binds cholesterol and a range of oxysterols. Cholesterol binding promotes the formation of a complex with PP2A and a tyrosine phosphatase which dephosphorylate ERK1/2, whereas 25- hydroxycholesterol causes its disassembly. Regulates cholesterol efflux by decreasing ABCA1 stability (807 aa)
        score_image score_image score_image   0.986
OSBPL9
oxysterol binding protein-like 9 (746 aa)
        score_image   score_image   0.985
SCAF4
SR-related CTD-associated factor 4; May act to physically and functionally link transcription and pre-mRNA processing (By similarity) (1147 aa)
        score_image       0.967
MPST
mercaptopyruvate sulfurtransferase; Transfer of a sulfur ion to cyanide or to other thiol compounds. Also has weak rhodanese activity. Detoxifies cyanide and is required for thiosulfate biosynthesis. Acts as an antioxidant. In combination with cysteine aminotransferase (CAT), contributes to the catabolism of cysteine and is an important producer of hydrogen sulfide in the brain, retina and vascular endothelial cells. Hydrogen sulfide H(2)S is an important synaptic modulator, signaling molecule, smooth muscle contractor and neuroprotectant. Its production by the 3MST/CAT pathway is regu [...] (317 aa)
      score_image score_image       0.964
TARDBP
TAR DNA binding protein (414 aa)
            score_image   0.940
UBC
ubiquitin C (685 aa)
        score_image       0.940
ZFYVE27
zinc finger, FYVE domain containing 27 (416 aa)
        score_image   score_image   0.939
YIF1A
Yip1 interacting factor homolog A (S. cerevisiae); Possible role in transport between endoplasmic reticulum and Golgi (293 aa)
        score_image   score_image   0.931
FAM82A2
family with sequence similarity 82, member A2; Involved in cellular calcium homeostasis regulation. May participate in differentiation and apoptosis of keratinocytes. Overexpression induces apoptosis (470 aa)
            score_image   0.923
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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