VWA1 protein (Homo sapiens) - STRING network view

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protein of unknown 3D structure

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Score

VWA1

von Willebrand factor A domain containing 1; Promotes matrix assembly (By similarity) (445 aa)

Predicted Functional Partners:

HSPG2

0.968

RERE

0.873

COL19A1

0.860

GRASP

0.729

PRDM10

0.646

DLG5

0.555

INADL

0.555

PDZD2

0.555

NOTCH1

0.550

TPD52L1

0.544

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COL19A1	VWA1	ENSP00000316030	ENSP00000417185	collagen, type XIX, alpha 1	von Willebrand factor A domain containing 1; Promotes matrix assembly (By similarity)	0.860
DLG5	VWA1	ENSP00000361467	ENSP00000417185	discs, large homolog 5 (Drosophila)	von Willebrand factor A domain containing 1; Promotes matrix assembly (By similarity)	0.555
GRASP	PRDM10	ENSP00000293662	ENSP00000351686	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein; Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses (By similarity)	PR domain containing 10	0.563
GRASP	RERE	ENSP00000293662	ENSP00000338629	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein; Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses (By similarity)	arginine-glutamic acid dipeptide (RE) repeats; Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death	0.455
GRASP	VWA1	ENSP00000293662	ENSP00000417185	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein; Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses (By similarity)	von Willebrand factor A domain containing 1; Promotes matrix assembly (By similarity)	0.729
HSPG2	PRDM10	ENSP00000363827	ENSP00000351686	heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development	PR domain containing 10	0.534
HSPG2	VWA1	ENSP00000363827	ENSP00000417185	heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development	von Willebrand factor A domain containing 1; Promotes matrix assembly (By similarity)	0.968
INADL	VWA1	ENSP00000360200	ENSP00000417185	InaD-like (Drosophila)	von Willebrand factor A domain containing 1; Promotes matrix assembly (By similarity)	0.555
NOTCH1	PRDM10	ENSP00000277541	ENSP00000351686	notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...]	PR domain containing 10	0.624
NOTCH1	VWA1	ENSP00000277541	ENSP00000417185	notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...]	von Willebrand factor A domain containing 1; Promotes matrix assembly (By similarity)	0.550
PDZD2	VWA1	ENSP00000282493	ENSP00000417185	PDZ domain containing 2	von Willebrand factor A domain containing 1; Promotes matrix assembly (By similarity)	0.555
PRDM10	GRASP	ENSP00000351686	ENSP00000293662	PR domain containing 10	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein; Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses (By similarity)	0.563
PRDM10	HSPG2	ENSP00000351686	ENSP00000363827	PR domain containing 10	heparan sulfate proteoglycan 2; Integral component of basement membranes. Component of the glomerular basement membrane (GBM), responsible for the fixed negative electrostatic membrane charge, and which provides a barrier which is both size- and charge-selective. It serves as an attachment substrate for cells. Plays essential roles in vascularization. Critical for normal heart development and for regulating the vascular response to injury. Also required for avascular cartilage development	0.534
PRDM10	NOTCH1	ENSP00000351686	ENSP00000277541	PR domain containing 10	notch 1; Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. May be important for normal lymphocyte function. In altered form, may contribute to transformation or progression in some T-cell neoplasms. Involved in the maturation of both CD4+ and CD8+ c [...]	0.624
PRDM10	VWA1	ENSP00000351686	ENSP00000417185	PR domain containing 10	von Willebrand factor A domain containing 1; Promotes matrix assembly (By similarity)	0.646
RERE	GRASP	ENSP00000338629	ENSP00000293662	arginine-glutamic acid dipeptide (RE) repeats; Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death	GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein; Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses (By similarity)	0.455
RERE	VWA1	ENSP00000338629	ENSP00000417185	arginine-glutamic acid dipeptide (RE) repeats; Plays a role as a transcriptional repressor during development. May play a role in the control of cell survival. Overexpression of RERE recruits BAX to the nucleus particularly to POD and triggers caspase-3 activation, leading to cell death	von Willebrand factor A domain containing 1; Promotes matrix assembly (By similarity)	0.873
TPD52L1	VWA1	ENSP00000434142	ENSP00000417185	tumor protein D52-like 1	von Willebrand factor A domain containing 1; Promotes matrix assembly (By similarity)	0.544
VWA1	COL19A1	ENSP00000417185	ENSP00000316030	von Willebrand factor A domain containing 1; Promotes matrix assembly (By similarity)	collagen, type XIX, alpha 1	0.860
VWA1	DLG5	ENSP00000417185	ENSP00000361467	von Willebrand factor A domain containing 1; Promotes matrix assembly (By similarity)	discs, large homolog 5 (Drosophila)	0.555

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