node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CKMT1A | PARP15 | ENSP00000406577 | ENSP00000417214 | creatine kinase, mitochondrial 1A; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity | 0.509 |
CKMT1B | PARP15 | ENSP00000300283 | ENSP00000417214 | creatine kinase, mitochondrial 1B | poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity | 0.509 |
CKMT2 | PARP15 | ENSP00000254035 | ENSP00000417214 | creatine kinase, mitochondrial 2 (sarcomeric); Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity | 0.509 |
DTX3L | IRF7 | ENSP00000296161 | ENSP00000329411 | deltex 3-like (Drosophila); Ubiquitin ligase that mediates monoubiquitination of ’Lys-91’ of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post- translational modifications such as H4 ’Lys-20’ methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1- dependen [...] | interferon regulatory factor 7; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent [...] | 0.440 |
DTX3L | PARP15 | ENSP00000296161 | ENSP00000417214 | deltex 3-like (Drosophila); Ubiquitin ligase that mediates monoubiquitination of ’Lys-91’ of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post- translational modifications such as H4 ’Lys-20’ methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1- dependen [...] | poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity | 0.849 |
DTX3L | PARP9 | ENSP00000296161 | ENSP00000353512 | deltex 3-like (Drosophila); Ubiquitin ligase that mediates monoubiquitination of ’Lys-91’ of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post- translational modifications such as H4 ’Lys-20’ methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1- dependen [...] | poly (ADP-ribose) polymerase family, member 9; In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes | 0.995 |
IRF7 | DTX3L | ENSP00000329411 | ENSP00000296161 | interferon regulatory factor 7; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent [...] | deltex 3-like (Drosophila); Ubiquitin ligase that mediates monoubiquitination of ’Lys-91’ of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post- translational modifications such as H4 ’Lys-20’ methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1- dependen [...] | 0.440 |
IRF7 | PARP15 | ENSP00000329411 | ENSP00000417214 | interferon regulatory factor 7; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent [...] | poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity | 0.518 |
IRF7 | PARP9 | ENSP00000329411 | ENSP00000353512 | interferon regulatory factor 7; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent [...] | poly (ADP-ribose) polymerase family, member 9; In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes | 0.882 |
PARP15 | CKMT1A | ENSP00000417214 | ENSP00000406577 | poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity | creatine kinase, mitochondrial 1A; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | 0.509 |
PARP15 | CKMT1B | ENSP00000417214 | ENSP00000300283 | poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity | creatine kinase, mitochondrial 1B | 0.509 |
PARP15 | CKMT2 | ENSP00000417214 | ENSP00000254035 | poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity | creatine kinase, mitochondrial 2 (sarcomeric); Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa | 0.509 |
PARP15 | DTX3L | ENSP00000417214 | ENSP00000296161 | poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity | deltex 3-like (Drosophila); Ubiquitin ligase that mediates monoubiquitination of ’Lys-91’ of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post- translational modifications such as H4 ’Lys-20’ methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1- dependen [...] | 0.849 |
PARP15 | IRF7 | ENSP00000417214 | ENSP00000329411 | poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity | interferon regulatory factor 7; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent [...] | 0.518 |
PARP15 | PARP16 | ENSP00000417214 | ENSP00000261888 | poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity | poly (ADP-ribose) polymerase family, member 16; Mono-ADP-ribosyltransferase targeting the karyopherin KPNB1. Plays a role in unfolded protein response (UPR), by ADP- ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors | 0.530 |
PARP15 | PARP6 | ENSP00000417214 | ENSP00000287196 | poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity | poly (ADP-ribose) polymerase family, member 6 | 0.649 |
PARP15 | PARP8 | ENSP00000417214 | ENSP00000281631 | poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity | poly (ADP-ribose) polymerase family, member 8 | 0.581 |
PARP15 | PARP9 | ENSP00000417214 | ENSP00000353512 | poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity | poly (ADP-ribose) polymerase family, member 9; In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes | 0.509 |
PARP15 | TAL1 | ENSP00000417214 | ENSP00000294339 | poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity | T-cell acute lymphocytic leukemia 1; Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity) | 0.801 |
PARP16 | PARP15 | ENSP00000261888 | ENSP00000417214 | poly (ADP-ribose) polymerase family, member 16; Mono-ADP-ribosyltransferase targeting the karyopherin KPNB1. Plays a role in unfolded protein response (UPR), by ADP- ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors | poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity | 0.530 |