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STRINGSTRING
CKMT1A CKMT1A CKMT1B CKMT1B TAL1 TAL1 PARP15 PARP15 CKMT2 CKMT2 IRF7 IRF7 DTX3L DTX3L PARP6 PARP6 PARP9 PARP9 PARP8 PARP8 PARP16 PARP16
"PARP15" - poly in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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experimentally determined
Predicted Interactions
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gene co-occurrence
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textmining
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co-expression
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[Homology]
Score
PARP15poly (ADP-ribose) polymerase family, member 15; Transcriptional repressor. Has ADP-ribosyltransferase activity (678 aa)    
Predicted Functional Partners:
DTX3L
deltex 3-like (Drosophila); Ubiquitin ligase that mediates monoubiquitination of ’Lys-91’ of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post- translational modifications such as H4 ’Lys-20’ methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1- dependen [...] (740 aa)
      score_image     score_image   0.849
TAL1
T-cell acute lymphocytic leukemia 1; Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity) (331 aa)
            score_image   0.801
PARP6
poly (ADP-ribose) polymerase family, member 6 (630 aa)
            score_image   0.649
PARP8
poly (ADP-ribose) polymerase family, member 8 (854 aa)
            score_image   0.581
PARP16
poly (ADP-ribose) polymerase family, member 16; Mono-ADP-ribosyltransferase targeting the karyopherin KPNB1. Plays a role in unfolded protein response (UPR), by ADP- ribosylating and activating EIF2AK3 and ERN1, two important UPR effectors (323 aa)
            score_image   0.530
IRF7
interferon regulatory factor 7; Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88- independent pathway and the TLR-activated, MyD88-dependent [...] (516 aa)
      score_image     score_image   0.518
PARP9
poly (ADP-ribose) polymerase family, member 9; In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes (854 aa)
      score_image     score_image score_image 0.509
CKMT1A
creatine kinase, mitochondrial 1A; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (417 aa)
            score_image   0.509
CKMT1B
creatine kinase, mitochondrial 1B (417 aa)
            score_image   0.509
CKMT2
creatine kinase, mitochondrial 2 (sarcomeric); Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa (419 aa)
            score_image   0.509
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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