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STRINGSTRING
SPOCK3 SPOCK3 TXN2 TXN2 ENOSF1 ENOSF1 GOLIM4 GOLIM4 BET1L BET1L GOLGB1 GOLGB1 ENSG00000260371 ENSG00000260371 LMAN1 LMAN1 GOLPH3 GOLPH3 COG3 COG3 GORASP1 GORASP1
"GOLIM4" - golgi integral membrane protein 4 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
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Cooccurence
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Textmining
[Homology]
Score
GOLIM4golgi integral membrane protein 4; Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi (696 aa)    
Predicted Functional Partners:
TXN2
thioredoxin 2; Has an anti-apoptotic function and plays an important role in the regulation of mitochondrial membrane potential. Could be involved in the resistance to anti-tumor agents. Possesses a dithiol-reducing activity (166 aa)
        score_image       0.644
ENOSF1
enolase superfamily member 1; May regulate thymidylate synthase activity (450 aa)
            score_image   0.619
GOLGB1
golgin B1; May participate in forming intercisternal cross-bridges of the Golgi complex (3259 aa)
            score_image   0.590
LMAN1
lectin, mannose-binding, 1 (510 aa)
            score_image   0.533
GOLPH3
golgi phosphoprotein 3 (coat-protein); Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in modulation of mTOR signaling. Involved in the regulation of mitochondrial lipids, leading to increase of mitochondrial mass. Potential oncogene (298 aa)
            score_image   0.510
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 (436 aa)
            score_image   0.490
BET1L
blocked early in transport 1 homolog (S. cerevisiae)-like; Vesicle SNARE required for targeting and fusion of retrograde transport vesicles with the Golgi complex. Required for the integrity of the Golgi complex (By similarity) (111 aa)
            score_image   0.477
GORASP1
golgi reassembly stacking protein 1, 65kDa; Stacking factor involved in the postmitotic assembly of Golgi stacks from mitotic Golgi fragments. Key structural protein required for the maintenance of the Golgi apparatus integrity- its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis. Also mediates, via its interaction with GM130, the docking of transport vesicles with the Golgi membranes (440 aa)
            score_image   0.451
ENSG00000260371
Uncharacterized protein (156 aa)
            score_image   0.447
COG3
component of oligomeric golgi complex 3; Involved in ER-Golgi transport (828 aa)
            score_image   0.416
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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