DDI2 protein (Homo sapiens) - STRING network view

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DDI2

DNA-damage inducible 1 homolog 2 (S. cerevisiae) (399 aa)

Predicted Functional Partners:

UBC

0.995

PSMD2

0.887

RAD23A

0.871

RAD23B

0.871

PSMD4

0.793

UBB

0.773

STX2

0.747

STX3

0.747

STX1A

0.747

STX1B

0.747

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDI2	PSMD2	ENSP00000417748	ENSP00000310129	DNA-damage inducible 1 homolog 2 (S. cerevisiae)	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins	0.887
DDI2	PSMD4	ENSP00000417748	ENSP00000357879	DNA-damage inducible 1 homolog 2 (S. cerevisiae)	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion	0.793
DDI2	RAD23A	ENSP00000417748	ENSP00000467024	DNA-damage inducible 1 homolog 2 (S. cerevisiae)	RAD23 homolog A (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to ’Lys-48’-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to ’Lys-63’-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome	0.871
DDI2	RAD23B	ENSP00000417748	ENSP00000350708	DNA-damage inducible 1 homolog 2 (S. cerevisiae)	RAD23 homolog B (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum- associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome	0.871
DDI2	STX1A	ENSP00000417748	ENSP00000222812	DNA-damage inducible 1 homolog 2 (S. cerevisiae)	syntaxin 1A (brain)	0.747
DDI2	STX1B	ENSP00000417748	ENSP00000215095	DNA-damage inducible 1 homolog 2 (S. cerevisiae)	syntaxin 1B; Potentially involved in docking of synaptic vesicles at presynaptic active zones. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm (By similarity)	0.747
DDI2	STX2	ENSP00000417748	ENSP00000376178	DNA-damage inducible 1 homolog 2 (S. cerevisiae)	syntaxin 2; Essential for epithelial morphogenesis. May mediate Ca(2+)-regulation of exocytosis acrosomal reaction in sperm	0.747
DDI2	STX3	ENSP00000417748	ENSP00000338562	DNA-damage inducible 1 homolog 2 (S. cerevisiae)	syntaxin 3; Potentially involved in docking of synaptic vesicles at presynaptic active zones	0.747
DDI2	UBB	ENSP00000417748	ENSP00000304697	DNA-damage inducible 1 homolog 2 (S. cerevisiae)	ubiquitin B	0.773
DDI2	UBC	ENSP00000417748	ENSP00000344818	DNA-damage inducible 1 homolog 2 (S. cerevisiae)	ubiquitin C	0.995
PSMD2	DDI2	ENSP00000310129	ENSP00000417748	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins	DNA-damage inducible 1 homolog 2 (S. cerevisiae)	0.887
PSMD2	PSMD4	ENSP00000310129	ENSP00000357879	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion	0.999
PSMD2	RAD23A	ENSP00000310129	ENSP00000467024	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins	RAD23 homolog A (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to ’Lys-48’-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to ’Lys-63’-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome	0.928
PSMD2	RAD23B	ENSP00000310129	ENSP00000350708	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins	RAD23 homolog B (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum- associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome	0.960
PSMD2	UBB	ENSP00000310129	ENSP00000304697	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins	ubiquitin B	0.984
PSMD2	UBC	ENSP00000310129	ENSP00000344818	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins	ubiquitin C	0.999
PSMD4	DDI2	ENSP00000357879	ENSP00000417748	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion	DNA-damage inducible 1 homolog 2 (S. cerevisiae)	0.793
PSMD4	PSMD2	ENSP00000357879	ENSP00000310129	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion	proteasome (prosome, macropain) 26S subunit, non-ATPase, 2; Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins	0.999
PSMD4	RAD23A	ENSP00000357879	ENSP00000467024	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion	RAD23 homolog A (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to ’Lys-48’-linked polyubiquitin chains in a length-dependent manner and with a lower affinity to ’Lys-63’-linked polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome	0.999
PSMD4	RAD23B	ENSP00000357879	ENSP00000350708	proteasome (prosome, macropain) 26S subunit, non-ATPase, 4; Binds and presumably selects ubiquitin-conjugates for destruction. Displays selectivity for longer polyubiquitin chains. Modulates intestinal fluid secretion	RAD23 homolog B (S. cerevisiae); Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Binds to polyubiquitin chains. Proposed to be capable to bind simultaneously to the 26S proteasome and to polyubiquitinated substrates and to deliver ubiquitinated proteins to the proteasome. May play a role in endoplasmic reticulum- associated degradation (ERAD) of misfolded glycoproteins by association with PNGase and delivering deglycosylated proteins to the proteasome	0.999

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