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STRINGSTRING
AQP6 AQP6 AQP10 AQP10 AQP5 AQP5 AQP3 AQP3 GPD2 GPD2 GK5 GK5 ENSG00000250424 ENSG00000250424 AQP4 AQP4 AQP1 AQP1 AQP7 AQP7 AQP9 AQP9
"GK5" - glycerol kinase 5 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
GK5glycerol kinase 5 (putative) (529 aa)    
Predicted Functional Partners:
GPD2
glycerol-3-phosphate dehydrogenase 2 (mitochondrial) (727 aa)
score_image score_image score_image score_image     score_image   0.884
AQP10
aquaporin 10; Water channel required to promote glycerol permeability and water transport across cell membranes. May contribute to water transport in the upper portion of small intestine. Isoform 2 is not permeable to urea and glycerol (301 aa)
score_image     score_image     score_image   0.791
AQP3
aquaporin 3 (Gill blood group); Water channel required to promote glycerol permeability and water transport across cell membranes. Acts as a glycerol transporter in skin and plays an important role in regulating SC (stratum corneum) and epidermal glycerol content. Involved in skin hydration, wound healing, and tumorigenesis. Provides kidney medullary collecting duct with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient. Slightly permeable to urea and may function as a water and urea exit mechanism in antidiuresis in collecting duct ce [...] (292 aa)
score_image     score_image     score_image   0.791
AQP7
aquaporin 7; Forms a channel for water and glycerol (342 aa)
score_image     score_image     score_image   0.791
AQP9
aquaporin 9; Forms a channel with a broad specificity. Mediates passage of a wide variety of non-charged solutes including carbamides, polyols, purines, and pyrimidines in a phloretin- and mercury-sensitive manner, whereas amino acids, cyclic sugars, Na(+), K(+), Cl(-), and deprotonated monocarboxylates are excluded. Also permeable to urea and glycerol (295 aa)
score_image     score_image     score_image   0.791
ENSG00000250424
Uncharacterized protein (446 aa)
score_image     score_image     score_image   0.779
AQP4
aquaporin 4; Forms a water-specific channel. Osmoreceptor which regulates body water balance and mediates water flow within the central nervous system (323 aa)
score_image     score_image     score_image   0.779
AQP6
aquaporin 6, kidney specific; Forms a water-specific channel that participates in distinct physiological functions such as glomerular filtration, tubular endocytosis and acid-base metabolism (By similarity) (282 aa)
score_image     score_image     score_image   0.779
AQP1
aquaporin 1 (Colton blood group); Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient (269 aa)
score_image     score_image     score_image   0.779
AQP5
aquaporin 5; Forms a water-specific channel. Implicated in the generation of saliva, tears, and pulmonary secretions (265 aa)
score_image     score_image     score_image   0.779
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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