| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CHL1 | CNTN6 | ENSP00000256509 | ENSP00000341882 | cell adhesion molecule with homology to L1CAM (close homolog of L1); Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dep [...] | contactin 6; Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity) | 0.933 |
| CHL1 | CNTNAP4 | ENSP00000256509 | ENSP00000418741 | cell adhesion molecule with homology to L1CAM (close homolog of L1); Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dep [...] | contactin associated protein-like 4 | 0.740 |
| CNTN1 | CNTN2 | ENSP00000325660 | ENSP00000330633 | contactin 1; Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurit [...] | contactin 2 (axonal); May play a role in the initial growth and guidance of axons. May be involved in cell adhesion | 0.579 |
| CNTN1 | CNTNAP4 | ENSP00000325660 | ENSP00000418741 | contactin 1; Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurit [...] | contactin associated protein-like 4 | 0.742 |
| CNTN1 | NFASC | ENSP00000325660 | ENSP00000344786 | contactin 1; Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurit [...] | neurofascin | 0.916 |
| CNTN1 | NRCAM | ENSP00000325660 | ENSP00000368314 | contactin 1; Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurit [...] | neuronal cell adhesion molecule; Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier (By similarity) | 0.846 |
| CNTN2 | CNTN1 | ENSP00000330633 | ENSP00000325660 | contactin 2 (axonal); May play a role in the initial growth and guidance of axons. May be involved in cell adhesion | contactin 1; Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurit [...] | 0.579 |
| CNTN2 | CNTNAP4 | ENSP00000330633 | ENSP00000418741 | contactin 2 (axonal); May play a role in the initial growth and guidance of axons. May be involved in cell adhesion | contactin associated protein-like 4 | 0.782 |
| CNTN2 | NRCAM | ENSP00000330633 | ENSP00000368314 | contactin 2 (axonal); May play a role in the initial growth and guidance of axons. May be involved in cell adhesion | neuronal cell adhesion molecule; Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier (By similarity) | 0.964 |
| CNTN3 | CNTNAP4 | ENSP00000263665 | ENSP00000418741 | contactin 3 (plasmacytoma associated); Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity) | contactin associated protein-like 4 | 0.747 |
| CNTN4 | CNTNAP4 | ENSP00000380602 | ENSP00000418741 | contactin 4; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis | contactin associated protein-like 4 | 0.776 |
| CNTN5 | CNTNAP4 | ENSP00000279463 | ENSP00000418741 | contactin 5; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system (By similarity) | contactin associated protein-like 4 | 0.952 |
| CNTN6 | CHL1 | ENSP00000341882 | ENSP00000256509 | contactin 6; Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity) | cell adhesion molecule with homology to L1CAM (close homolog of L1); Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dep [...] | 0.933 |
| CNTN6 | CNTNAP4 | ENSP00000341882 | ENSP00000418741 | contactin 6; Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination (By similarity) | contactin associated protein-like 4 | 0.760 |
| CNTNAP4 | CHL1 | ENSP00000418741 | ENSP00000256509 | contactin associated protein-like 4 | cell adhesion molecule with homology to L1CAM (close homolog of L1); Extracellular matrix and cell adhesion protein that plays a role in nervous system development and in synaptic plasticity. Both soluble and membranous forms promote neurite outgrowth of cerebellar and hippocampal neurons and suppress neuronal cell death. Plays a role in neuronal positioning of pyramidal neurons and in regulation of both the number of interneurons and the efficacy of GABAergic synapses. May play a role in regulating cell migration in nerve regeneration and cortical development. Potentiates integrin-dep [...] | 0.740 |
| CNTNAP4 | CNTN1 | ENSP00000418741 | ENSP00000325660 | contactin associated protein-like 4 | contactin 1; Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurit [...] | 0.742 |
| CNTNAP4 | CNTN2 | ENSP00000418741 | ENSP00000330633 | contactin associated protein-like 4 | contactin 2 (axonal); May play a role in the initial growth and guidance of axons. May be involved in cell adhesion | 0.782 |
| CNTNAP4 | CNTN3 | ENSP00000418741 | ENSP00000263665 | contactin associated protein-like 4 | contactin 3 (plasmacytoma associated); Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity (By similarity) | 0.747 |
| CNTNAP4 | CNTN4 | ENSP00000418741 | ENSP00000380602 | contactin associated protein-like 4 | contactin 4; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis | 0.776 |
| CNTNAP4 | CNTN5 | ENSP00000418741 | ENSP00000279463 | contactin associated protein-like 4 | contactin 5; Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity in the cerebral cortical neurons but not in hippocampal neurons. Probably involved in neuronal activity in the auditory system (By similarity) | 0.952 |
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