| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| BAX | BECN1 | ENSP00000293288 | ENSP00000355231 | BCL2-associated X protein | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | 0.580 |
| BAX | SH3GLB1 | ENSP00000293288 | ENSP00000418744 | BCL2-associated X protein | SH3-domain GRB2-like endophilin B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion | 0.935 |
| BAX | UBC | ENSP00000293288 | ENSP00000344818 | BCL2-associated X protein | ubiquitin C | 0.945 |
| BAX | UVRAG | ENSP00000293288 | ENSP00000348455 | BCL2-associated X protein | UV radiation resistance associated | 0.932 |
| BECN1 | BAX | ENSP00000355231 | ENSP00000293288 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | BCL2-associated X protein | 0.580 |
| BECN1 | SH3GLB1 | ENSP00000355231 | ENSP00000418744 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | SH3-domain GRB2-like endophilin B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion | 0.870 |
| BECN1 | UBC | ENSP00000355231 | ENSP00000344818 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | ubiquitin C | 0.980 |
| BECN1 | UVRAG | ENSP00000355231 | ENSP00000348455 | beclin 1, autophagy related; Plays a central role in autophagy. Required for the abcission step in cytokinesis. May play a role in antiviral host defense. Protects against infection by a neurovirulent strain of Sindbis virus | UV radiation resistance associated | 0.999 |
| BIN1 | SH3GLB1 | ENSP00000316779 | ENSP00000418744 | bridging integrator 1 | SH3-domain GRB2-like endophilin B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion | 0.824 |
| BIN1 | SH3GLB2 | ENSP00000316779 | ENSP00000361640 | bridging integrator 1 | SH3-domain GRB2-like endophilin B2 | 0.608 |
| BIN1 | SH3KBP1 | ENSP00000316779 | ENSP00000380921 | bridging integrator 1 | SH3-domain kinase binding protein 1; Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by intera [...] | 0.512 |
| BIN1 | SYNJ1 | ENSP00000316779 | ENSP00000409667 | bridging integrator 1 | synaptojanin 1; Inositol 5-phosphatase which has a role in clathrin- mediated endocytosis | 0.971 |
| BIN1 | UBC | ENSP00000316779 | ENSP00000344818 | bridging integrator 1 | ubiquitin C | 0.566 |
| IGF1R | SH3GLB1 | ENSP00000268035 | ENSP00000418744 | insulin-like growth factor 1 receptor; Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc [...] | SH3-domain GRB2-like endophilin B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion | 0.804 |
| IGF1R | SH3GLB2 | ENSP00000268035 | ENSP00000361640 | insulin-like growth factor 1 receptor; Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc [...] | SH3-domain GRB2-like endophilin B2 | 0.800 |
| IGF1R | SH3KBP1 | ENSP00000268035 | ENSP00000380921 | insulin-like growth factor 1 receptor; Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc [...] | SH3-domain kinase binding protein 1; Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by intera [...] | 0.806 |
| IGF1R | UBC | ENSP00000268035 | ENSP00000344818 | insulin-like growth factor 1 receptor; Receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). Binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity. The activated IGF1R is involved in cell growth and survival control. IGF1R is crucial for tumor transformation and survival of malignant cell. Ligand binding activates the receptor kinase, leading to receptor autophosphorylation, and tyrosines phosphorylation of multiple substrates, that function as signaling adapter proteins including, the insulin-receptor substrates (IRS1/2), Shc [...] | ubiquitin C | 0.999 |
| NTRK1 | SH3GLB1 | ENSP00000431418 | ENSP00000418744 | neurotrophic tyrosine kinase, receptor, type 1 | SH3-domain GRB2-like endophilin B1; May be required for normal outer mitochondrial membrane dynamics. Required for coatomer-mediated retrograde transport in certain cells. May recruit other proteins to membranes with high curvature. May promote membrane fusion | 0.800 |
| NTRK1 | SH3GLB2 | ENSP00000431418 | ENSP00000361640 | neurotrophic tyrosine kinase, receptor, type 1 | SH3-domain GRB2-like endophilin B2 | 0.800 |
| NTRK1 | SH3KBP1 | ENSP00000431418 | ENSP00000380921 | neurotrophic tyrosine kinase, receptor, type 1 | SH3-domain kinase binding protein 1; Adapter protein involved in regulating diverse signal transduction pathways. Involved in the regulation of endocytosis and lysosomal degradation of ligand-induced receptor tyrosine kinases, including EGFR and MET/hepatocyte growth factor receptor, through a association with CBL and endophilins. The association with CBL, and thus the receptor internalization, may inhibited by an interaction with PDCD6IP and/or SPRY2. Involved in regulation of ligand-dependent endocytosis of the IgE receptor. Attenuates phosphatidylinositol 3-kinase activity by intera [...] | 0.800 |
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