node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AATF | DIEXF | ENSP00000225402 | ENSP00000419005 | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | digestive organ expansion factor homolog (zebrafish); Regulates the p53 pathway to control the expansion growth of digestive organs (By similarity) | 0.921 |
AATF | ENSG00000248354 | ENSP00000225402 | ENSP00000415634 | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | Uncharacterized protein | 0.952 |
AATF | MPHOSPH10 | ENSP00000225402 | ENSP00000244230 | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing | 0.960 |
AATF | NOC2L | ENSP00000225402 | ENSP00000317992 | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | nucleolar complex associated 2 homolog (S. cerevisiae); Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter | 0.937 |
AATF | PWP2 | ENSP00000225402 | ENSP00000291576 | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | PWP2 periodic tryptophan protein homolog (yeast) | 0.972 |
AATF | RRP9 | ENSP00000225402 | ENSP00000232888 | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast); Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA | 0.925 |
AATF | TBL3 | ENSP00000225402 | ENSP00000454836 | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | transducin (beta)-like 3 | 0.927 |
AATF | UTP3 | ENSP00000225402 | ENSP00000254803 | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae); Essential for gene silencing- has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity) | 0.826 |
AATF | UTP6 | ENSP00000225402 | ENSP00000261708 | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | UTP6, small subunit (SSU) processome component, homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) | 0.874 |
AATF | WDR36 | ENSP00000225402 | ENSP00000423067 | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | WD repeat domain 36; Involved in T-cell activation and highly co-regulated with IL2 | 0.833 |
DIEXF | AATF | ENSP00000419005 | ENSP00000225402 | digestive organ expansion factor homolog (zebrafish); Regulates the p53 pathway to control the expansion growth of digestive organs (By similarity) | apoptosis antagonizing transcription factor; May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for th [...] | 0.921 |
DIEXF | ENSG00000248354 | ENSP00000419005 | ENSP00000415634 | digestive organ expansion factor homolog (zebrafish); Regulates the p53 pathway to control the expansion growth of digestive organs (By similarity) | Uncharacterized protein | 0.891 |
DIEXF | MPHOSPH10 | ENSP00000419005 | ENSP00000244230 | digestive organ expansion factor homolog (zebrafish); Regulates the p53 pathway to control the expansion growth of digestive organs (By similarity) | M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing | 0.964 |
DIEXF | NOC2L | ENSP00000419005 | ENSP00000317992 | digestive organ expansion factor homolog (zebrafish); Regulates the p53 pathway to control the expansion growth of digestive organs (By similarity) | nucleolar complex associated 2 homolog (S. cerevisiae); Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter | 0.894 |
DIEXF | PWP2 | ENSP00000419005 | ENSP00000291576 | digestive organ expansion factor homolog (zebrafish); Regulates the p53 pathway to control the expansion growth of digestive organs (By similarity) | PWP2 periodic tryptophan protein homolog (yeast) | 0.897 |
DIEXF | RRP9 | ENSP00000419005 | ENSP00000232888 | digestive organ expansion factor homolog (zebrafish); Regulates the p53 pathway to control the expansion growth of digestive organs (By similarity) | ribosomal RNA processing 9, small subunit (SSU) processome component, homolog (yeast); Component of a nucleolar small nuclear ribonucleoprotein particle (snoRNP) thought to participate in the processing and modification of pre-ribosomal RNA | 0.896 |
DIEXF | TBL3 | ENSP00000419005 | ENSP00000454836 | digestive organ expansion factor homolog (zebrafish); Regulates the p53 pathway to control the expansion growth of digestive organs (By similarity) | transducin (beta)-like 3 | 0.933 |
DIEXF | UTP3 | ENSP00000419005 | ENSP00000254803 | digestive organ expansion factor homolog (zebrafish); Regulates the p53 pathway to control the expansion growth of digestive organs (By similarity) | UTP3, small subunit (SSU) processome component, homolog (S. cerevisiae); Essential for gene silencing- has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity) | 0.991 |
DIEXF | UTP6 | ENSP00000419005 | ENSP00000261708 | digestive organ expansion factor homolog (zebrafish); Regulates the p53 pathway to control the expansion growth of digestive organs (By similarity) | UTP6, small subunit (SSU) processome component, homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity) | 0.892 |
DIEXF | WDR36 | ENSP00000419005 | ENSP00000423067 | digestive organ expansion factor homolog (zebrafish); Regulates the p53 pathway to control the expansion growth of digestive organs (By similarity) | WD repeat domain 36; Involved in T-cell activation and highly co-regulated with IL2 | 0.916 |