| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AFM | GGTLC2 | ENSP00000226355 | ENSP00000419751 | afamin; Vitamin E binding protein. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the regulation and transport of vitamin E at the blood-brain barrier (By similarity) | gamma-glutamyltransferase light chain 2 | 0.420 |
| AFM | ZBTB20 | ENSP00000226355 | ENSP00000419153 | afamin; Vitamin E binding protein. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the regulation and transport of vitamin E at the blood-brain barrier (By similarity) | zinc finger and BTB domain containing 20; May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses | 0.562 |
| AFM | ZHX2 | ENSP00000226355 | ENSP00000314709 | afamin; Vitamin E binding protein. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the regulation and transport of vitamin E at the blood-brain barrier (By similarity) | zinc fingers and homeoboxes 2; Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA | 0.485 |
| AFP | GGT1 | ENSP00000379138 | ENSP00000248923 | alpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties | gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive | 0.506 |
| AFP | ZBTB20 | ENSP00000379138 | ENSP00000419153 | alpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties | zinc finger and BTB domain containing 20; May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses | 0.681 |
| AFP | ZHX2 | ENSP00000379138 | ENSP00000314709 | alpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties | zinc fingers and homeoboxes 2; Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA | 0.608 |
| CCDC170 | SUV420H1 | ENSP00000239374 | ENSP00000305899 | coiled-coil domain containing 170 | suppressor of variegation 4-20 homolog 1 (Drosophila) | 0.449 |
| CCDC170 | ZBTB20 | ENSP00000239374 | ENSP00000419153 | coiled-coil domain containing 170 | zinc finger and BTB domain containing 20; May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses | 0.618 |
| FBP1 | ZBTB20 | ENSP00000364475 | ENSP00000419153 | fructose-1,6-bisphosphatase 1 | zinc finger and BTB domain containing 20; May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses | 0.830 |
| FTH1 | ZBTB20 | ENSP00000273550 | ENSP00000419153 | ferritin, heavy polypeptide 1; Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity) | zinc finger and BTB domain containing 20; May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses | 0.510 |
| GGT1 | AFP | ENSP00000248923 | ENSP00000379138 | gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive | alpha-fetoprotein; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties | 0.506 |
| GGT1 | ZBTB20 | ENSP00000248923 | ENSP00000419153 | gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive | zinc finger and BTB domain containing 20; May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses | 0.605 |
| GGT1 | ZHX2 | ENSP00000248923 | ENSP00000314709 | gamma-glutamyltransferase 1; Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Catalyzes the transfer of the glutamyl moiety of glutathione to amino acids and dipeptide acceptors. Alternatively, glutathione can be hydrolyzed to give Cys-Gly and gamma glutamate. Isoform 3 seems to be inactive | zinc fingers and homeoboxes 2; Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA | 0.516 |
| GGTLC2 | AFM | ENSP00000419751 | ENSP00000226355 | gamma-glutamyltransferase light chain 2 | afamin; Vitamin E binding protein. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the regulation and transport of vitamin E at the blood-brain barrier (By similarity) | 0.420 |
| GGTLC2 | ZBTB20 | ENSP00000419751 | ENSP00000419153 | gamma-glutamyltransferase light chain 2 | zinc finger and BTB domain containing 20; May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses | 0.686 |
| GGTLC2 | ZHX2 | ENSP00000419751 | ENSP00000314709 | gamma-glutamyltransferase light chain 2 | zinc fingers and homeoboxes 2; Acts as a transcriptional repressor. Represses the promoter activity of the CDC25C gene stimulated by NFYA | 0.660 |
| SUV420H1 | CCDC170 | ENSP00000305899 | ENSP00000239374 | suppressor of variegation 4-20 homolog 1 (Drosophila) | coiled-coil domain containing 170 | 0.449 |
| SUV420H1 | ZBTB20 | ENSP00000305899 | ENSP00000419153 | suppressor of variegation 4-20 homolog 1 (Drosophila) | zinc finger and BTB domain containing 20; May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses | 0.518 |
| XRN1 | ZBTB20 | ENSP00000264951 | ENSP00000419153 | 5’-3’ exoribonuclease 1; Major 5’-3’ exoribonuclease involved in mRNA decay. Required for the 5’-3’-processing of the G4 tetraplex-containing DNA and RNA substrates. The kinetic of hydrolysis is faster for G4 RNA tetraplex than for G4 DNA tetraplex and monomeric RNA tetraplex. Binds to RNA and DNA (By similarity). Plays a role in replication-dependent histone mRNA degradation. May act as a tumor suppressor protein in osteogenic sarcoma (OGS) | zinc finger and BTB domain containing 20; May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses | 0.543 |
| ZBTB20 | AFM | ENSP00000419153 | ENSP00000226355 | zinc finger and BTB domain containing 20; May be a transcription factor that may be involved in hematopoiesis, oncogenesis, and immune responses | afamin; Vitamin E binding protein. May transport vitamin E in body fluids under conditions where the lipoprotein system is not sufficient. May be involved in the regulation and transport of vitamin E at the blood-brain barrier (By similarity) | 0.562 |
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