node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAMKV | CHP1 | ENSP00000419195 | ENSP00000335632 | CaM kinase-like vesicle-associated | calcineurin-like EF hand protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exc [...] | 0.477 |
CAMKV | CHP2 | ENSP00000419195 | ENSP00000300113 | CaM kinase-like vesicle-associated | calcineurin-like EF hand protein 2; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation- induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to t [...] | 0.477 |
CAMKV | CIB1 | ENSP00000419195 | ENSP00000333873 | CaM kinase-like vesicle-associated | calcium and integrin binding 1 (calmyrin); May convert the inactive conformation of integrin alpha- IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle [...] | 0.477 |
CAMKV | CIB4 | ENSP00000419195 | ENSP00000288861 | CaM kinase-like vesicle-associated | calcium and integrin binding family member 4 | 0.477 |
CAMKV | F11 | ENSP00000419195 | ENSP00000384957 | CaM kinase-like vesicle-associated | coagulation factor XI; Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX | 0.472 |
CAMKV | PPP3R1 | ENSP00000419195 | ENSP00000234310 | CaM kinase-like vesicle-associated | protein phosphatase 3, regulatory subunit B, alpha; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity | 0.477 |
CAMKV | PPP3R2 | ENSP00000419195 | ENSP00000363939 | CaM kinase-like vesicle-associated | protein phosphatase 3, regulatory subunit B, beta; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity) | 0.477 |
CAMKV | RHBDL3 | ENSP00000419195 | ENSP00000269051 | CaM kinase-like vesicle-associated | rhomboid, veinlet-like 3 (Drosophila); May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors (By similarity) | 0.441 |
CAMKV | TESC | ENSP00000419195 | ENSP00000334785 | CaM kinase-like vesicle-associated | tescalcin; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calc [...] | 0.477 |
CAMKV | ZNF576 | ENSP00000419195 | ENSP00000337852 | CaM kinase-like vesicle-associated | zinc finger protein 576; May be involved in transcriptional regulation | 0.467 |
CHP1 | CAMKV | ENSP00000335632 | ENSP00000419195 | calcineurin-like EF hand protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exc [...] | CaM kinase-like vesicle-associated | 0.477 |
CHP1 | RHBDL3 | ENSP00000335632 | ENSP00000269051 | calcineurin-like EF hand protein 1; Calcium-binding protein involved in different processes such as regulation of vesicular trafficking, plasma membrane Na(+)/H(+) exchanger and gene transcription. Involved in the constitutive exocytic membrane traffic. Mediates the association between microtubules and membrane-bound organelles of the endoplasmic reticulum and Golgi apparatus and is also required for the targeting and fusion of transcytotic vesicles (TCV) with the plasma membrane. Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exc [...] | rhomboid, veinlet-like 3 (Drosophila); May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors (By similarity) | 0.448 |
CHP2 | CAMKV | ENSP00000300113 | ENSP00000419195 | calcineurin-like EF hand protein 2; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation- induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to t [...] | CaM kinase-like vesicle-associated | 0.477 |
CHP2 | RHBDL3 | ENSP00000300113 | ENSP00000269051 | calcineurin-like EF hand protein 2; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation- induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to t [...] | rhomboid, veinlet-like 3 (Drosophila); May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors (By similarity) | 0.448 |
CIB1 | CAMKV | ENSP00000333873 | ENSP00000419195 | calcium and integrin binding 1 (calmyrin); May convert the inactive conformation of integrin alpha- IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle [...] | CaM kinase-like vesicle-associated | 0.477 |
CIB1 | RHBDL3 | ENSP00000333873 | ENSP00000269051 | calcium and integrin binding 1 (calmyrin); May convert the inactive conformation of integrin alpha- IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle [...] | rhomboid, veinlet-like 3 (Drosophila); May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors (By similarity) | 0.448 |
CIB4 | CAMKV | ENSP00000288861 | ENSP00000419195 | calcium and integrin binding family member 4 | CaM kinase-like vesicle-associated | 0.477 |
CIB4 | RHBDL3 | ENSP00000288861 | ENSP00000269051 | calcium and integrin binding family member 4 | rhomboid, veinlet-like 3 (Drosophila); May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors (By similarity) | 0.448 |
F11 | CAMKV | ENSP00000384957 | ENSP00000419195 | coagulation factor XI; Factor XI triggers the middle phase of the intrinsic pathway of blood coagulation by activating factor IX | CaM kinase-like vesicle-associated | 0.472 |
PPP3R1 | CAMKV | ENSP00000234310 | ENSP00000419195 | protein phosphatase 3, regulatory subunit B, alpha; Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity | CaM kinase-like vesicle-associated | 0.477 |