node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGAP26 | FAM115A | ENSP00000274498 | ENSP00000419235 | Rho GTPase activating protein 26; GTPase-activating protein for RHOA and CDC42 | family with sequence similarity 115, member A | 0.616 |
ARHGAP26 | UBC | ENSP00000274498 | ENSP00000344818 | Rho GTPase activating protein 26; GTPase-activating protein for RHOA and CDC42 | ubiquitin C | 0.721 |
ARHGAP26 | ZNF579 | ENSP00000274498 | ENSP00000320188 | Rho GTPase activating protein 26; GTPase-activating protein for RHOA and CDC42 | zinc finger protein 579; May be involved in transcriptional regulation | 0.423 |
DBN1 | FAM115A | ENSP00000292385 | ENSP00000419235 | drebrin 1; Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively | family with sequence similarity 115, member A | 0.517 |
DBN1 | UBC | ENSP00000292385 | ENSP00000344818 | drebrin 1; Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively | ubiquitin C | 0.798 |
FAM115A | ARHGAP26 | ENSP00000419235 | ENSP00000274498 | family with sequence similarity 115, member A | Rho GTPase activating protein 26; GTPase-activating protein for RHOA and CDC42 | 0.616 |
FAM115A | DBN1 | ENSP00000419235 | ENSP00000292385 | family with sequence similarity 115, member A | drebrin 1; Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively | 0.517 |
FAM115A | TCF3 | ENSP00000419235 | ENSP00000262965 | family with sequence similarity 115, member A | transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs- 5’-CANNTG-3’. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region | 0.499 |
FAM115A | TOLLIP | ENSP00000419235 | ENSP00000314733 | family with sequence similarity 115, member A | toll interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity | 0.456 |
FAM115A | UBC | ENSP00000419235 | ENSP00000344818 | family with sequence similarity 115, member A | ubiquitin C | 0.968 |
FAM115A | USP13 | ENSP00000419235 | ENSP00000263966 | family with sequence similarity 115, member A | ubiquitin specific peptidase 13 (isopeptidase T-3); Deubiquitinase that mediates deubiquitination of target proteins such as BECN1, MITF, SKP2 and USP10 and is involved in various processes such as autophagy and endoplasmic reticulum- associated degradation (ERAD). Component of a regulatory loop that controls autophagy and p53/TP53 levels- mediates deubiquitination of BECN1, a key regulator of autophagy, leading to stabilize the PIK3C3/VPS34-containing complexes. Also deubiquitinates USP10, an essential regulator of p53/TP53 stability. In turn, PIK3C3/VPS34- containing complexes regula [...] | 0.743 |
FAM115A | WIPI2 | ENSP00000419235 | ENSP00000288828 | family with sequence similarity 115, member A | WD repeat domain, phosphoinositide interacting 2; Probable early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to PtdIns3P. May bind PtdIns3P | 0.445 |
FAM115A | ZNF579 | ENSP00000419235 | ENSP00000320188 | family with sequence similarity 115, member A | zinc finger protein 579; May be involved in transcriptional regulation | 0.581 |
FAM115A | ZNF592 | ENSP00000419235 | ENSP00000299927 | family with sequence similarity 115, member A | zinc finger protein 592; May be involved in transcriptional regulation | 0.576 |
TCF3 | FAM115A | ENSP00000262965 | ENSP00000419235 | transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs- 5’-CANNTG-3’. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region | family with sequence similarity 115, member A | 0.499 |
TCF3 | UBC | ENSP00000262965 | ENSP00000344818 | transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs- 5’-CANNTG-3’. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region | ubiquitin C | 0.774 |
TOLLIP | FAM115A | ENSP00000314733 | ENSP00000419235 | toll interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity | family with sequence similarity 115, member A | 0.456 |
TOLLIP | UBC | ENSP00000314733 | ENSP00000344818 | toll interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Recruits IRAK1 to the IL-1 receptor complex. Inhibits IRAK1 phosphorylation and kinase activity | ubiquitin C | 0.999 |
UBC | ARHGAP26 | ENSP00000344818 | ENSP00000274498 | ubiquitin C | Rho GTPase activating protein 26; GTPase-activating protein for RHOA and CDC42 | 0.721 |
UBC | DBN1 | ENSP00000344818 | ENSP00000292385 | ubiquitin C | drebrin 1; Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively | 0.798 |