TTC26 protein (Homo sapiens) - STRING network view

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TTC26

tetratricopeptide repeat domain 26; May play a critical role in ciliogenesis and normal cilia function (By similarity) (554 aa)

Predicted Functional Partners:

IFT46

0.679

CLUAP1

0.679

CCDC39

0.634

UBC

0.620

DNAAF2

0.618

IFT122

0.607

TTC30B

0.552

IFT27

0.550

IFT140

0.546

TTC30A

0.532

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC39	CLUAP1	ENSP00000405708	ENSP00000460850	coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly	clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity)	0.434
CCDC39	DNAAF2	ENSP00000405708	ENSP00000298292	coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly	dynein, axonemal, assembly factor 2; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment	0.783
CCDC39	TTC26	ENSP00000405708	ENSP00000419279	coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly	tetratricopeptide repeat domain 26; May play a critical role in ciliogenesis and normal cilia function (By similarity)	0.634
CLUAP1	CCDC39	ENSP00000460850	ENSP00000405708	clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity)	coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly	0.434
CLUAP1	IFT140	ENSP00000460850	ENSP00000406012	clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity)	intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance	0.403
CLUAP1	IFT46	ENSP00000460850	ENSP00000264020	clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity)	intraflagellar transport 46 homolog (Chlamydomonas); Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity)	0.535
CLUAP1	TTC26	ENSP00000460850	ENSP00000419279	clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity)	tetratricopeptide repeat domain 26; May play a critical role in ciliogenesis and normal cilia function (By similarity)	0.679
CLUAP1	UBC	ENSP00000460850	ENSP00000344818	clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity)	ubiquitin C	0.491
DNAAF2	CCDC39	ENSP00000298292	ENSP00000405708	dynein, axonemal, assembly factor 2; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment	coiled-coil domain containing 39; Required for assembly of dynein regulatory complex (DRC) and inner dynein arm complexes, which are responsible for ciliary beat regulation, thereby playing a central role in motility in cilia and flagella. Not required for outer dynein arm complexes assembly	0.783
DNAAF2	TTC26	ENSP00000298292	ENSP00000419279	dynein, axonemal, assembly factor 2; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment	tetratricopeptide repeat domain 26; May play a critical role in ciliogenesis and normal cilia function (By similarity)	0.618
IFT122	IFT140	ENSP00000296266	ENSP00000406012	intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity)	intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance	0.975
IFT122	IFT27	ENSP00000296266	ENSP00000393541	intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity)	intraflagellar transport 27 homolog (Chlamydomonas); Possesses GTPase activity (By similarity)	0.812
IFT122	IFT46	ENSP00000296266	ENSP00000264020	intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity)	intraflagellar transport 46 homolog (Chlamydomonas); Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity)	0.625
IFT122	TTC26	ENSP00000296266	ENSP00000419279	intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity)	tetratricopeptide repeat domain 26; May play a critical role in ciliogenesis and normal cilia function (By similarity)	0.607
IFT122	UBC	ENSP00000296266	ENSP00000344818	intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity)	ubiquitin C	0.739
IFT140	CLUAP1	ENSP00000406012	ENSP00000460850	intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance	clusterin associated protein 1; Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling (By similarity)	0.403
IFT140	IFT122	ENSP00000406012	ENSP00000296266	intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance	intraflagellar transport 122 homolog (Chlamydomonas); Required for cilia formation during neuronal patterning. Acts as a negative regulator of Shh signaling. Required to recruit TULP3 to primary cilia (By similarity)	0.975
IFT140	IFT27	ENSP00000406012	ENSP00000393541	intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance	intraflagellar transport 27 homolog (Chlamydomonas); Possesses GTPase activity (By similarity)	0.888
IFT140	IFT46	ENSP00000406012	ENSP00000264020	intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance	intraflagellar transport 46 homolog (Chlamydomonas); Forms part of a complex involved in intraflagellar transport (IFT), the bi-directional movement of particles required for the assembly, maintenance and functioning of primary cilia. May play a role in chondrocyte maturation and skeletogenesis (By similarity)	0.790
IFT140	TTC26	ENSP00000406012	ENSP00000419279	intraflagellar transport 140 homolog (Chlamydomonas); Component of the IFT complex A (IFT-A), a complex required for retrograde ciliary transport. Plays a pivotal role in proper development and function of ciliated cells. Involved in ciliogenesis and cilia maintenance	tetratricopeptide repeat domain 26; May play a critical role in ciliogenesis and normal cilia function (By similarity)	0.546

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