ADCY5 protein (Homo sapiens) - STRING network view

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ADCY5

adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase (1261 aa)

Predicted Functional Partners:

PRKACA

0.980

PDE4A

0.979

MTNR1B

0.977

GNAS

0.973

GIPR

0.973

GNAI1

0.972

PRKAR2B

0.970

PRKAR1A

0.970

PRKAR1B

0.969

ADCY7

0.969

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY5	ADCY7	ENSP00000419361	ENSP00000254235	adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	0.969
ADCY5	GIPR	ENSP00000419361	ENSP00000467494	adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	gastric inhibitory polypeptide receptor; This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase	0.973
ADCY5	GNAI1	ENSP00000419361	ENSP00000343027	adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	0.972
ADCY5	GNAS	ENSP00000419361	ENSP00000360141	adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	GNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity)	0.973
ADCY5	MTNR1B	ENSP00000419361	ENSP00000257068	adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	melatonin receptor 1B; High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity	0.977
ADCY5	PDE4A	ENSP00000419361	ENSP00000270474	adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	phosphodiesterase 4A, cAMP-specific	0.979
ADCY5	PRKACA	ENSP00000419361	ENSP00000309591	adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...]	0.980
ADCY5	PRKAR1A	ENSP00000419361	ENSP00000351410	adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	protein kinase, cAMP-dependent, regulatory, type I, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells	0.970
ADCY5	PRKAR1B	ENSP00000419361	ENSP00000353415	adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	protein kinase, cAMP-dependent, regulatory, type I, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells	0.969
ADCY5	PRKAR2B	ENSP00000419361	ENSP00000265717	adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	protein kinase, cAMP-dependent, regulatory, type II, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase	0.970
ADCY7	ADCY5	ENSP00000254235	ENSP00000419361	adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	adenylate cyclase 5; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	0.969
ADCY7	GIPR	ENSP00000254235	ENSP00000467494	adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	gastric inhibitory polypeptide receptor; This is a receptor for GIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase	0.900
ADCY7	GNAI1	ENSP00000254235	ENSP00000343027	adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1	0.938
ADCY7	GNAS	ENSP00000254235	ENSP00000360141	adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	GNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity)	0.920
ADCY7	MTNR1B	ENSP00000254235	ENSP00000257068	adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	melatonin receptor 1B; High affinity receptor for melatonin. Likely to mediates the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity	0.913
ADCY7	PDE4A	ENSP00000254235	ENSP00000270474	adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	phosphodiesterase 4A, cAMP-specific	0.971
ADCY7	PRKACA	ENSP00000254235	ENSP00000309591	adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	protein kinase, cAMP-dependent, catalytic, alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA, TRPC1 and VASP. RORA is activated by phosphorylation. Required for glucose-mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in th [...]	0.956
ADCY7	PRKAR1A	ENSP00000254235	ENSP00000351410	adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	protein kinase, cAMP-dependent, regulatory, type I, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells	0.969
ADCY7	PRKAR1B	ENSP00000254235	ENSP00000353415	adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	protein kinase, cAMP-dependent, regulatory, type I, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells	0.969
ADCY7	PRKAR2B	ENSP00000254235	ENSP00000265717	adenylate cyclase 7; This is a membrane-bound, calcium-inhibitable adenylyl cyclase	protein kinase, cAMP-dependent, regulatory, type II, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase	0.969

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