PEX5L protein (Homo sapiens) - STRING network view

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PEX5L

peroxisomal biogenesis factor 5-like; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence (By similarity) (626 aa)

Predicted Functional Partners:

PEX14

0.976

PEX13

0.972

HCN1

0.959

RAB8B

0.958

PEX12

0.949

PEX7

0.940

HCN2

0.940

PEX10

0.906

PEX6

0.876

PCNA

0.858

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
HCN1	HCN2	ENSP00000307342	ENSP00000251287	hyperpolarization activated cyclic nucleotide-gated potassium channel 1; Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli	hyperpolarization activated cyclic nucleotide-gated potassium channel 2; Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity)	0.994
HCN1	PEX5L	ENSP00000307342	ENSP00000419975	hyperpolarization activated cyclic nucleotide-gated potassium channel 1; Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli	peroxisomal biogenesis factor 5-like; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence (By similarity)	0.959
HCN1	RAB8B	ENSP00000307342	ENSP00000312734	hyperpolarization activated cyclic nucleotide-gated potassium channel 1; Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli	RAB8B, member RAS oncogene family; May be involved in vesicular trafficking and neurotransmitter release (By similarity). May participate in cell junction dynamics in Sertoli cells (By similarity)	0.565
HCN2	HCN1	ENSP00000251287	ENSP00000307342	hyperpolarization activated cyclic nucleotide-gated potassium channel 2; Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity)	hyperpolarization activated cyclic nucleotide-gated potassium channel 1; Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Activated by cAMP, and at 10-100 times higher concentrations, also by cGMP. May mediate responses to sour stimuli	0.994
HCN2	PEX5L	ENSP00000251287	ENSP00000419975	hyperpolarization activated cyclic nucleotide-gated potassium channel 2; Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity)	peroxisomal biogenesis factor 5-like; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence (By similarity)	0.940
HCN2	RAB8B	ENSP00000251287	ENSP00000312734	hyperpolarization activated cyclic nucleotide-gated potassium channel 2; Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. Activated by cAMP. Modulated by intracellular chloride ions and pH; acidic pH shifts the activation to more negative voltages (By similarity)	RAB8B, member RAS oncogene family; May be involved in vesicular trafficking and neurotransmitter release (By similarity). May participate in cell junction dynamics in Sertoli cells (By similarity)	0.436
PCNA	PEX5L	ENSP00000368438	ENSP00000419975	proliferating cell nuclear antigen; Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase’s processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3’- 5’ exonuclease and 3’-phosphodiesterase, but not apurinic- apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA re [...]	peroxisomal biogenesis factor 5-like; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence (By similarity)	0.858
PEX10	PEX12	ENSP00000288774	ENSP00000225873	peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes	peroxisomal biogenesis factor 12; Required for protein import into peroxisomes	0.999
PEX10	PEX13	ENSP00000288774	ENSP00000295030	peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes	peroxisomal biogenesis factor 13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins	0.993
PEX10	PEX14	ENSP00000288774	ENSP00000349016	peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes	peroxisomal biogenesis factor 14; Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17	0.975
PEX10	PEX5L	ENSP00000288774	ENSP00000419975	peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes	peroxisomal biogenesis factor 5-like; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence (By similarity)	0.906
PEX10	PEX6	ENSP00000288774	ENSP00000303511	peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes	peroxisomal biogenesis factor 6; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes	0.878
PEX10	PEX7	ENSP00000288774	ENSP00000315680	peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes	peroxisomal biogenesis factor 7; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import	0.711
PEX12	PEX10	ENSP00000225873	ENSP00000288774	peroxisomal biogenesis factor 12; Required for protein import into peroxisomes	peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes	0.999
PEX12	PEX13	ENSP00000225873	ENSP00000295030	peroxisomal biogenesis factor 12; Required for protein import into peroxisomes	peroxisomal biogenesis factor 13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins	0.994
PEX12	PEX14	ENSP00000225873	ENSP00000349016	peroxisomal biogenesis factor 12; Required for protein import into peroxisomes	peroxisomal biogenesis factor 14; Component of the peroxisomal translocation machinery with PEX13 and PEX17. Interacts with both the PTS1 and PTS2 receptors. Binds directly to PEX17	0.988
PEX12	PEX5L	ENSP00000225873	ENSP00000419975	peroxisomal biogenesis factor 12; Required for protein import into peroxisomes	peroxisomal biogenesis factor 5-like; Accessory subunit of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels, regulating their cell-surface expression and cyclic nucleotide dependence (By similarity)	0.949
PEX12	PEX6	ENSP00000225873	ENSP00000303511	peroxisomal biogenesis factor 12; Required for protein import into peroxisomes	peroxisomal biogenesis factor 6; Involved in peroxisome biosynthesis. Required for stability of the PTS1 receptor. Anchored by PEX26 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes	0.877
PEX12	PEX7	ENSP00000225873	ENSP00000315680	peroxisomal biogenesis factor 12; Required for protein import into peroxisomes	peroxisomal biogenesis factor 7; Binds to the N-terminal PTS2-type peroxisomal targeting signal and plays an essential role in peroxisomal protein import	0.763
PEX13	PEX10	ENSP00000295030	ENSP00000288774	peroxisomal biogenesis factor 13; Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins	peroxisomal biogenesis factor 10; Somewhat implicated in the biogenesis of peroxisomes	0.993

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