| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCDC101 | MAP3K7 | ENSP00000316114 | ENSP00000358335 | coiled-coil domain containing 101; Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated ’Lys-4’ of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA- type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation | mitogen-activated protein kinase kinase kinase 7 | 0.863 |
| CCDC101 | MBIP | ENSP00000316114 | ENSP00000399718 | coiled-coil domain containing 101; Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated ’Lys-4’ of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA- type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation | MAP3K12 binding inhibitory protein 1; Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 | 0.922 |
| CCDC101 | POLE3 | ENSP00000316114 | ENSP00000363284 | coiled-coil domain containing 101; Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated ’Lys-4’ of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA- type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation | polymerase (DNA directed), epsilon 3, accessory subunit; Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 | 0.945 |
| CCDC101 | POLE4 | ENSP00000316114 | ENSP00000420176 | coiled-coil domain containing 101; Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated ’Lys-4’ of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA- type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation | polymerase (DNA-directed), epsilon 4, accessory subunit; May play a role in allowing polymerase epsilon to carry out its replication and/or repair function | 0.909 |
| CCDC101 | YEATS2 | ENSP00000316114 | ENSP00000306983 | coiled-coil domain containing 101; Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated ’Lys-4’ of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA- type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation | YEATS domain containing 2; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 | 0.976 |
| CHRAC1 | POLD1 | ENSP00000220913 | ENSP00000406046 | chromatin accessibility complex 1; Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1 | polymerase (DNA directed), delta 1, catalytic subunit; Possesses two enzymatic activities- DNA synthesis (polymerase) and an exonucleolytic activity that degrades single stranded DNA in the 3’- to 5’-direction. Required with its accessory proteins (proliferating cell nuclear antigen (PCNA) and replication factor C (RFC) or activator 1) for leading strand synthesis. Also involved in completing Okazaki fragments initiated by the DNA polymerase alpha/primase complex | 0.902 |
| CHRAC1 | POLE | ENSP00000220913 | ENSP00000322570 | chromatin accessibility complex 1; Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1 | polymerase (DNA directed), epsilon, catalytic subunit; Participates in DNA repair and in chromosomal DNA replication | 0.958 |
| CHRAC1 | POLE2 | ENSP00000220913 | ENSP00000216367 | chromatin accessibility complex 1; Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1 | polymerase (DNA directed), epsilon 2, accessory subunit; Participates in DNA repair and in chromosomal DNA replication | 0.974 |
| CHRAC1 | POLE3 | ENSP00000220913 | ENSP00000363284 | chromatin accessibility complex 1; Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1 | polymerase (DNA directed), epsilon 3, accessory subunit; Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 | 0.999 |
| CHRAC1 | POLE4 | ENSP00000220913 | ENSP00000420176 | chromatin accessibility complex 1; Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1 | polymerase (DNA-directed), epsilon 4, accessory subunit; May play a role in allowing polymerase epsilon to carry out its replication and/or repair function | 0.912 |
| CHRAC1 | REV3L | ENSP00000220913 | ENSP00000351697 | chromatin accessibility complex 1; Forms a complex with DNA polymerase epsilon subunit POLE3 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome remodeling activity of ISWI/SNF2H and ACF1 | REV3-like, polymerase (DNA directed), zeta, catalytic subunit; Interacts with MAD2L2 to form the error prone DNA polymerase zeta involved in translesion DNA synthesis | 0.902 |
| MAP3K7 | CCDC101 | ENSP00000358335 | ENSP00000316114 | mitogen-activated protein kinase kinase kinase 7 | coiled-coil domain containing 101; Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated ’Lys-4’ of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA- type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation | 0.863 |
| MAP3K7 | MBIP | ENSP00000358335 | ENSP00000399718 | mitogen-activated protein kinase kinase kinase 7 | MAP3K12 binding inhibitory protein 1; Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 | 0.836 |
| MAP3K7 | POLE3 | ENSP00000358335 | ENSP00000363284 | mitogen-activated protein kinase kinase kinase 7 | polymerase (DNA directed), epsilon 3, accessory subunit; Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 | 0.799 |
| MAP3K7 | POLE4 | ENSP00000358335 | ENSP00000420176 | mitogen-activated protein kinase kinase kinase 7 | polymerase (DNA-directed), epsilon 4, accessory subunit; May play a role in allowing polymerase epsilon to carry out its replication and/or repair function | 0.932 |
| MAP3K7 | YEATS2 | ENSP00000358335 | ENSP00000306983 | mitogen-activated protein kinase kinase kinase 7 | YEATS domain containing 2; Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 | 0.864 |
| MBIP | CCDC101 | ENSP00000399718 | ENSP00000316114 | MAP3K12 binding inhibitory protein 1; Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 | coiled-coil domain containing 101; Involved in transcriptional regulation, through association with histone acetyltransferase (HAT) SAGA-type complexes like the TFTC-HAT, ATAC or STAGA complexes. Specifically recognizes and binds methylated ’Lys-4’ of histone H3 (H3K4me), with a preference for trimethylated form (H3K4me3). In the SAGA- type complexes, required to recruit complexes to H3K4me. May be involved in MYC-mediated oncogenic transformation | 0.922 |
| MBIP | MAP3K7 | ENSP00000399718 | ENSP00000358335 | MAP3K12 binding inhibitory protein 1; Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 | mitogen-activated protein kinase kinase kinase 7 | 0.836 |
| MBIP | POLE3 | ENSP00000399718 | ENSP00000363284 | MAP3K12 binding inhibitory protein 1; Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 | polymerase (DNA directed), epsilon 3, accessory subunit; Forms a complex with DNA polymerase epsilon subunit CHRAC1 and binds naked DNA, which is then incorporated into chromatin, aided by the nucleosome-remodeling activity of ISWI/SNF2H and ACF1 | 0.886 |
| MBIP | POLE4 | ENSP00000399718 | ENSP00000420176 | MAP3K12 binding inhibitory protein 1; Inhibits the MAP3K12 activity to induce the activation of the JNK/SAPK pathway. Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4 | polymerase (DNA-directed), epsilon 4, accessory subunit; May play a role in allowing polymerase epsilon to carry out its replication and/or repair function | 0.907 |
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