CASR protein (Homo sapiens) - STRING network view

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CASR

calcium-sensing receptor; Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system (1088 aa)

Predicted Functional Partners:

PTH

0.974

NPSR1

0.969

APP

0.966

PROKR1

0.944

AVP

0.944

AGT

0.936

SST

0.936

KNG1

0.936

CNR1

0.934

GCG

0.933

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGT	APP	ENSP00000355627	ENSP00000284981	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	amyloid beta (A4) precursor protein	0.905
AGT	AVP	ENSP00000355627	ENSP00000369647	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	0.949
AGT	CASR	ENSP00000355627	ENSP00000420194	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	calcium-sensing receptor; Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system	0.936
AGT	CNR1	ENSP00000355627	ENSP00000358511	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	cannabinoid receptor 1 (brain)	0.909
AGT	GCG	ENSP00000355627	ENSP00000387662	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life	0.939
AGT	KNG1	ENSP00000355627	ENSP00000265023	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...]	0.989
AGT	NPSR1	ENSP00000355627	ENSP00000352839	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	neuropeptide S receptor 1	0.900
AGT	PROKR1	ENSP00000355627	ENSP00000303775	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	prokineticin receptor 1; Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase	0.901
AGT	PTH	ENSP00000355627	ENSP00000282091	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells	0.410
AGT	SST	ENSP00000355627	ENSP00000287641	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	somatostatin; Somatostatin inhibits the release of somatotropin	0.936
APP	AGT	ENSP00000284981	ENSP00000355627	amyloid beta (A4) precursor protein	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	0.905
APP	AVP	ENSP00000284981	ENSP00000369647	amyloid beta (A4) precursor protein	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	0.918
APP	CASR	ENSP00000284981	ENSP00000420194	amyloid beta (A4) precursor protein	calcium-sensing receptor; Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system	0.966
APP	CNR1	ENSP00000284981	ENSP00000358511	amyloid beta (A4) precursor protein	cannabinoid receptor 1 (brain)	0.911
APP	GCG	ENSP00000284981	ENSP00000387662	amyloid beta (A4) precursor protein	glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life	0.922
APP	KNG1	ENSP00000284981	ENSP00000265023	amyloid beta (A4) precursor protein	kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...]	0.970
APP	NPSR1	ENSP00000284981	ENSP00000352839	amyloid beta (A4) precursor protein	neuropeptide S receptor 1	0.900
APP	PROKR1	ENSP00000284981	ENSP00000303775	amyloid beta (A4) precursor protein	prokineticin receptor 1; Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase	0.900
APP	SST	ENSP00000284981	ENSP00000287641	amyloid beta (A4) precursor protein	somatostatin; Somatostatin inhibits the release of somatotropin	0.923
AVP	AGT	ENSP00000369647	ENSP00000355627	arginine vasopressin; Neurophysin 2 specifically binds vasopressin	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	0.949

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