node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGT | APP | ENSP00000355627 | ENSP00000284981 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | amyloid beta (A4) precursor protein | 0.905 |
AGT | AVP | ENSP00000355627 | ENSP00000369647 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | 0.949 |
AGT | CASR | ENSP00000355627 | ENSP00000420194 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | calcium-sensing receptor; Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system | 0.936 |
AGT | CNR1 | ENSP00000355627 | ENSP00000358511 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | cannabinoid receptor 1 (brain) | 0.909 |
AGT | GCG | ENSP00000355627 | ENSP00000387662 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life | 0.939 |
AGT | KNG1 | ENSP00000355627 | ENSP00000265023 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...] | 0.989 |
AGT | NPSR1 | ENSP00000355627 | ENSP00000352839 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | neuropeptide S receptor 1 | 0.900 |
AGT | PROKR1 | ENSP00000355627 | ENSP00000303775 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | prokineticin receptor 1; Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase | 0.901 |
AGT | PTH | ENSP00000355627 | ENSP00000282091 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2- deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells | 0.410 |
AGT | SST | ENSP00000355627 | ENSP00000287641 | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | somatostatin; Somatostatin inhibits the release of somatotropin | 0.936 |
APP | AGT | ENSP00000284981 | ENSP00000355627 | amyloid beta (A4) precursor protein | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | 0.905 |
APP | AVP | ENSP00000284981 | ENSP00000369647 | amyloid beta (A4) precursor protein | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | 0.918 |
APP | CASR | ENSP00000284981 | ENSP00000420194 | amyloid beta (A4) precursor protein | calcium-sensing receptor; Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system | 0.966 |
APP | CNR1 | ENSP00000284981 | ENSP00000358511 | amyloid beta (A4) precursor protein | cannabinoid receptor 1 (brain) | 0.911 |
APP | GCG | ENSP00000284981 | ENSP00000387662 | amyloid beta (A4) precursor protein | glucagon; Glicentin may modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life | 0.922 |
APP | KNG1 | ENSP00000284981 | ENSP00000265023 | amyloid beta (A4) precursor protein | kininogen 1; (1) Kininogens are inhibitors of thiol proteases; (2) HMW-kininogen plays an important role in blood coagulation by helping to position optimally prekallikrein and factor XI next to factor XII; (3) HMW-kininogen inhibits the thrombin- and plasmin- induced aggregation of thrombocytes; (4) the active peptide bradykinin that is released from HMW-kininogen shows a variety of physiological effects- (4A) influence in smooth muscle contraction, (4B) induction of hypotension, (4C) natriuresis and diuresis, (4D) decrease in blood glucose level, (4E) it is a mediator of inflammation [...] | 0.970 |
APP | NPSR1 | ENSP00000284981 | ENSP00000352839 | amyloid beta (A4) precursor protein | neuropeptide S receptor 1 | 0.900 |
APP | PROKR1 | ENSP00000284981 | ENSP00000303775 | amyloid beta (A4) precursor protein | prokineticin receptor 1; Receptor for prokineticin 1. Exclusively coupled to the G(q) subclass of heteromeric G proteins. Activation leads to mobilization of calcium, stimulation of phosphoinositide turnover and activation of p44/p42 mitogen-activated protein kinase | 0.900 |
APP | SST | ENSP00000284981 | ENSP00000287641 | amyloid beta (A4) precursor protein | somatostatin; Somatostatin inhibits the release of somatotropin | 0.923 |
AVP | AGT | ENSP00000369647 | ENSP00000355627 | arginine vasopressin; Neurophysin 2 specifically binds vasopressin | angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis | 0.949 |