node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARMC8 | CHM | ENSP00000420333 | ENSP00000350386 | armadillo repeat containing 8 | choroideremia (Rab escort protein 1); Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Also a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation | 0.740 |
ARMC8 | CTNNB1 | ENSP00000420333 | ENSP00000344456 | armadillo repeat containing 8 | catenin (cadherin-associated protein), beta 1, 88kDa; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation [...] | 0.725 |
ARMC8 | GID4 | ENSP00000420333 | ENSP00000268719 | armadillo repeat containing 8 | GID complex subunit 4, VID24 homolog (S. cerevisiae) | 0.868 |
ARMC8 | GID8 | ENSP00000420333 | ENSP00000266069 | armadillo repeat containing 8 | GID complex subunit 8 homolog (S. cerevisiae) | 0.980 |
ARMC8 | MAEA | ENSP00000420333 | ENSP00000302830 | armadillo repeat containing 8 | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | 0.938 |
ARMC8 | RAE1 | ENSP00000420333 | ENSP00000360286 | armadillo repeat containing 8 | RAE1 RNA export 1 homolog (S. pombe); Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton | 0.738 |
ARMC8 | RANBP9 | ENSP00000420333 | ENSP00000011619 | armadillo repeat containing 8 | RAN binding protein 9; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity o [...] | 0.630 |
ARMC8 | RMND5A | ENSP00000420333 | ENSP00000283632 | armadillo repeat containing 8 | required for meiotic nuclear division 5 homolog A (S. cerevisiae) | 0.925 |
ARMC8 | RMND5B | ENSP00000420333 | ENSP00000320623 | armadillo repeat containing 8 | required for meiotic nuclear division 5 homolog B (S. cerevisiae) | 0.918 |
ARMC8 | WDR26 | ENSP00000420333 | ENSP00000408108 | armadillo repeat containing 8 | WD repeat domain 26; May be involved in MAPK pathways | 0.859 |
CHM | ARMC8 | ENSP00000350386 | ENSP00000420333 | choroideremia (Rab escort protein 1); Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Also a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation | armadillo repeat containing 8 | 0.740 |
CHM | WDR26 | ENSP00000350386 | ENSP00000408108 | choroideremia (Rab escort protein 1); Binds unprenylated Rab proteins, presents it to the catalytic Rab GGTase dimer, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Also a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation | WD repeat domain 26; May be involved in MAPK pathways | 0.747 |
CTNNB1 | ARMC8 | ENSP00000344456 | ENSP00000420333 | catenin (cadherin-associated protein), beta 1, 88kDa; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation [...] | armadillo repeat containing 8 | 0.725 |
GID4 | ARMC8 | ENSP00000268719 | ENSP00000420333 | GID complex subunit 4, VID24 homolog (S. cerevisiae) | armadillo repeat containing 8 | 0.868 |
GID4 | GID8 | ENSP00000268719 | ENSP00000266069 | GID complex subunit 4, VID24 homolog (S. cerevisiae) | GID complex subunit 8 homolog (S. cerevisiae) | 0.912 |
GID4 | MAEA | ENSP00000268719 | ENSP00000302830 | GID complex subunit 4, VID24 homolog (S. cerevisiae) | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | 0.785 |
GID4 | RANBP9 | ENSP00000268719 | ENSP00000011619 | GID complex subunit 4, VID24 homolog (S. cerevisiae) | RAN binding protein 9; May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity o [...] | 0.923 |
GID4 | RMND5A | ENSP00000268719 | ENSP00000283632 | GID complex subunit 4, VID24 homolog (S. cerevisiae) | required for meiotic nuclear division 5 homolog A (S. cerevisiae) | 0.641 |
GID4 | RMND5B | ENSP00000268719 | ENSP00000320623 | GID complex subunit 4, VID24 homolog (S. cerevisiae) | required for meiotic nuclear division 5 homolog B (S. cerevisiae) | 0.578 |
GID4 | WDR26 | ENSP00000268719 | ENSP00000408108 | GID complex subunit 4, VID24 homolog (S. cerevisiae) | WD repeat domain 26; May be involved in MAPK pathways | 0.548 |