node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ADORA2A | CST7 | ENSP00000336630 | ENSP00000420384 | adenosine A2a receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system | 0.824 |
CDH11 | CST7 | ENSP00000268603 | ENSP00000420384 | cadherin 11, type 2, OB-cadherin (osteoblast); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system | 0.470 |
CST7 | ADORA2A | ENSP00000420384 | ENSP00000336630 | cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system | adenosine A2a receptor; Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase | 0.824 |
CST7 | CDH11 | ENSP00000420384 | ENSP00000268603 | cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system | cadherin 11, type 2, OB-cadherin (osteoblast); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types | 0.470 |
CST7 | CTSB | ENSP00000420384 | ENSP00000342070 | cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system | cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | 0.734 |
CST7 | CTSC | ENSP00000420384 | ENSP00000227266 | cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system | cathepsin C | 0.628 |
CST7 | CTSL1 | ENSP00000420384 | ENSP00000345344 | cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system | cathepsin L1; Important for the overall degradation of proteins in lysosomes | 0.665 |
CST7 | CTSS | ENSP00000420384 | ENSP00000357981 | cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | 0.475 |
CST7 | DBNL | ENSP00000420384 | ENSP00000417653 | cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system | drebrin-like; Adapter protein that binds F-actin and DNM1, and thereby plays a role in receptor-mediated endocytosis. Plays a role in the reorganization of the actin cytoskeleton, formation of cell projections, such as neurites, in neuron morphogenesis and synapse formation via its interaction with WASL and COBL. Does not bind G- actin and promote actin polymerization by itself. Required for the formation of organized podosome rosettes (By similarity). May act as a common effector of antigen receptor-signaling pathways in leukocytes. Acts as a key component of the immunological synapse [...] | 0.504 |
CST7 | PCCA | ENSP00000420384 | ENSP00000365462 | cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system | propionyl CoA carboxylase, alpha polypeptide | 0.755 |
CST7 | SH2D4A | ENSP00000420384 | ENSP00000265807 | cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system | SH2 domain containing 4A; Inhibits estrogen-induced cell proliferation by competing with PLCG for binding to ESR1, blocking the effect of estrogen on PLCG and repressing estrogen-induced proliferation. May play a role in T-cell development and function | 0.569 |
CST7 | SH3BP2 | ENSP00000420384 | ENSP00000422168 | cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system | SH3-domain binding protein 2; Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. Binds to phosphatidylinositols; linking the hemopoietic tyrosine kinase fes to the cytoplasmic membrane in a phosphorylation dependent mechanism | 0.572 |
CTSB | CST7 | ENSP00000342070 | ENSP00000420384 | cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system | 0.734 |
CTSB | CTSL1 | ENSP00000342070 | ENSP00000345344 | cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | cathepsin L1; Important for the overall degradation of proteins in lysosomes | 0.700 |
CTSC | CST7 | ENSP00000227266 | ENSP00000420384 | cathepsin C | cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system | 0.628 |
CTSC | CTSL1 | ENSP00000227266 | ENSP00000345344 | cathepsin C | cathepsin L1; Important for the overall degradation of proteins in lysosomes | 0.672 |
CTSL1 | CST7 | ENSP00000345344 | ENSP00000420384 | cathepsin L1; Important for the overall degradation of proteins in lysosomes | cystatin F (leukocystatin); Inhibits papain and cathepsin L but with affinities lower than other cystatins. May play a role in immune regulation through inhibition of a unique target in the hematopoietic system | 0.665 |
CTSL1 | CTSB | ENSP00000345344 | ENSP00000342070 | cathepsin L1; Important for the overall degradation of proteins in lysosomes | cathepsin B; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis | 0.700 |
CTSL1 | CTSC | ENSP00000345344 | ENSP00000227266 | cathepsin L1; Important for the overall degradation of proteins in lysosomes | cathepsin C | 0.672 |
CTSL1 | CTSS | ENSP00000345344 | ENSP00000357981 | cathepsin L1; Important for the overall degradation of proteins in lysosomes | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | 0.905 |