CNIH4 protein (Homo sapiens) - STRING network view

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CNIH4

cornichon homolog 4 (Drosophila) (139 aa)

Predicted Functional Partners:

TMED10

0.693

NUDT11

0.655

STX7

0.627

RCE1

0.580

STX4

0.579

KLHL18

0.571

BCAP29

0.569

WWC3

0.568

TMED4

0.563

TMED9

0.563

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCAP29	CNIH4	ENSP00000368414	ENSP00000420443	B-cell receptor-associated protein 29; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity)	cornichon homolog 4 (Drosophila)	0.569
BCAP29	WWC3	ENSP00000368414	ENSP00000370242	B-cell receptor-associated protein 29; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity)	WWC family member 3	0.502
CNIH4	BCAP29	ENSP00000420443	ENSP00000368414	cornichon homolog 4 (Drosophila)	B-cell receptor-associated protein 29; May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi. May be involved in CASP8-mediated apoptosis (By similarity)	0.569
CNIH4	KLHL18	ENSP00000420443	ENSP00000232766	cornichon homolog 4 (Drosophila)	kelch-like 18 (Drosophila)	0.571
CNIH4	NUDT11	ENSP00000420443	ENSP00000365160	cornichon homolog 4 (Drosophila)	nudix (nucleoside diphosphate linked moiety X)-type motif 11; Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate	0.655
CNIH4	RCE1	ENSP00000420443	ENSP00000309163	cornichon homolog 4 (Drosophila)	RCE1 homolog, prenyl protein protease (S. cerevisiae); Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1	0.580
CNIH4	STX4	ENSP00000420443	ENSP00000317714	cornichon homolog 4 (Drosophila)	syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones	0.579
CNIH4	STX7	ENSP00000420443	ENSP00000356918	cornichon homolog 4 (Drosophila)	syntaxin 7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes	0.627
CNIH4	TMED10	ENSP00000420443	ENSP00000303145	cornichon homolog 4 (Drosophila)	transmembrane emp24-like trafficking protein 10 (yeast); Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipi [...]	0.693
CNIH4	TMED4	ENSP00000420443	ENSP00000404042	cornichon homolog 4 (Drosophila)	transmembrane emp24 protein transport domain containing 4; Involved in vesicular protein trafficking, mainly in the early secretory pathway. targeting. Involved in the maintenance of the Golgi apparatus. Appears to play a role in the biosynthesis of secreted cargo including processing. Involved in endoplasmic reticulum stress response. May play a role in the regulation of heat-shock response and apoptosis (By similarity)	0.563
CNIH4	TMED9	ENSP00000420443	ENSP00000330945	cornichon homolog 4 (Drosophila)	transmembrane emp24 protein transport domain containing 9; Appears to be involved in vesicular protein trafficking, mainly in the early secretory pathway. In COPI vesicle-mediated retrograde transport involved in the coatomer recruitment to membranes of the early secretory pathway. Increases coatomer- dependent activity of ARFGAP2. Thought to play a crucial role in the specific retention of p24 complexes in cis-Golgi membranes; specifically contributes to the coupled localization of TMED2 and TMED10 in the cis-Golgi network. May be involved in organization of intracellular membranes, s [...]	0.563
CNIH4	WWC3	ENSP00000420443	ENSP00000370242	cornichon homolog 4 (Drosophila)	WWC family member 3	0.568
KLHL18	CNIH4	ENSP00000232766	ENSP00000420443	kelch-like 18 (Drosophila)	cornichon homolog 4 (Drosophila)	0.571
NUDT11	CNIH4	ENSP00000365160	ENSP00000420443	nudix (nucleoside diphosphate linked moiety X)-type motif 11; Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate	cornichon homolog 4 (Drosophila)	0.655
RCE1	CNIH4	ENSP00000309163	ENSP00000420443	RCE1 homolog, prenyl protein protease (S. cerevisiae); Proteolytically removes the C-terminal three residues of farnesylated and geranylated proteins. Seems to be able to process K-Ras, N-Ras, H-Ras, RAP1B and G-gamma-1	cornichon homolog 4 (Drosophila)	0.580
STX4	CNIH4	ENSP00000317714	ENSP00000420443	syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones	cornichon homolog 4 (Drosophila)	0.579
STX4	STX7	ENSP00000317714	ENSP00000356918	syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones	syntaxin 7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes	0.953
STX7	CNIH4	ENSP00000356918	ENSP00000420443	syntaxin 7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes	cornichon homolog 4 (Drosophila)	0.627
STX7	STX4	ENSP00000356918	ENSP00000317714	syntaxin 7; May be involved in protein trafficking from the plasma membrane to the early endosome (EE) as well as in homotypic fusion of endocytic organelles. Mediates the endocytic trafficking from early endosomes to late endosomes and lysosomes	syntaxin 4; Plasma membrane t-SNARE that mediates docking of transport vesicles. Necessary for the translocation of SLC2A4 from intracellular vesicles to the plasma membrane. Together with STXB3 and VAMP2, may also play a role in docking/fusion of intracellular GLUT4-containing vesicles with the cell surface in adipocytes (By similarity). May also play a role in docking of synaptic vesicles at presynaptic active zones	0.953
TMED10	CNIH4	ENSP00000303145	ENSP00000420443	transmembrane emp24-like trafficking protein 10 (yeast); Involved in vesicular protein trafficking. Mainly functions in the early secretory pathway. Thought to act as cargo receptor at the lumenal side for incorporation of secretory cargo molecules into transport vesicles and to be involved in vesicle coat formation at the cytoplasmic side. In COPII vesicle-mediated anterograde transport involved in the transport of GPI-anchored proteins and proposed to act togther with TMED2 as their cargo receptor; the function specifically implies SEC24C and SEC24D of the COPII vesicle coat and lipi [...]	cornichon homolog 4 (Drosophila)	0.693

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