| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| GOPC | KRT16 | ENSP00000357484 | ENSP00000301653 | golgi-associated PDZ and coiled-coil motif containing; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes | keratin 16 | 0.802 |
| GOPC | PVRL2 | ENSP00000357484 | ENSP00000252483 | golgi-associated PDZ and coiled-coil motif containing; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes | poliovirus receptor-related 2 (herpesvirus entry mediator B); Probable cell adhesion protein | 0.804 |
| GOPC | SEPP1 | ENSP00000357484 | ENSP00000420939 | golgi-associated PDZ and coiled-coil motif containing; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes | selenoprotein P, plasma, 1; Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis | 0.801 |
| GOPC | SEPT4 | ENSP00000357484 | ENSP00000321674 | golgi-associated PDZ and coiled-coil motif containing; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes | septin 4; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli | 0.800 |
| GPX2 | SEPP1 | ENSP00000374265 | ENSP00000420939 | glutathione peroxidase 2 (gastrointestinal); Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors | selenoprotein P, plasma, 1; Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis | 0.759 |
| GPX2 | SMCP | ENSP00000374265 | ENSP00000357754 | glutathione peroxidase 2 (gastrointestinal); Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors | sperm mitochondria-associated cysteine-rich protein; Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity) | 0.754 |
| GPX3 | SEPP1 | ENSP00000373477 | ENSP00000420939 | glutathione peroxidase 3 (plasma); Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione | selenoprotein P, plasma, 1; Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis | 0.680 |
| GPX3 | SMCP | ENSP00000373477 | ENSP00000357754 | glutathione peroxidase 3 (plasma); Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione | sperm mitochondria-associated cysteine-rich protein; Involved in sperm motility. Its absence is associated with genetic background dependent male infertility. Infertility may be due to reduced sperm motility in the female reproductive tract and inability to penetrate the oocyte zona pellucida (By similarity) | 0.629 |
| GPX3 | TNF | ENSP00000373477 | ENSP00000398698 | glutathione peroxidase 3 (plasma); Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione | tumor necrosis factor | 0.933 |
| KRT16 | GOPC | ENSP00000301653 | ENSP00000357484 | keratin 16 | golgi-associated PDZ and coiled-coil motif containing; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes | 0.802 |
| KRT16 | PVRL2 | ENSP00000301653 | ENSP00000252483 | keratin 16 | poliovirus receptor-related 2 (herpesvirus entry mediator B); Probable cell adhesion protein | 0.800 |
| KRT16 | SEPP1 | ENSP00000301653 | ENSP00000420939 | keratin 16 | selenoprotein P, plasma, 1; Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis | 0.818 |
| KRT16 | SEPT4 | ENSP00000301653 | ENSP00000321674 | keratin 16 | septin 4; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli | 0.808 |
| LRP2 | SEPP1 | ENSP00000263816 | ENSP00000420939 | low density lipoprotein receptor-related protein 2; Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid- hormone and para-thyroid-hormone-related protein release | selenoprotein P, plasma, 1; Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis | 0.836 |
| LRP8 | SEPP1 | ENSP00000303634 | ENSP00000420939 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the fore [...] | selenoprotein P, plasma, 1; Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis | 0.866 |
| PVRL2 | GOPC | ENSP00000252483 | ENSP00000357484 | poliovirus receptor-related 2 (herpesvirus entry mediator B); Probable cell adhesion protein | golgi-associated PDZ and coiled-coil motif containing; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes | 0.804 |
| PVRL2 | KRT16 | ENSP00000252483 | ENSP00000301653 | poliovirus receptor-related 2 (herpesvirus entry mediator B); Probable cell adhesion protein | keratin 16 | 0.800 |
| PVRL2 | SEPP1 | ENSP00000252483 | ENSP00000420939 | poliovirus receptor-related 2 (herpesvirus entry mediator B); Probable cell adhesion protein | selenoprotein P, plasma, 1; Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis | 0.802 |
| PVRL2 | SEPT4 | ENSP00000252483 | ENSP00000321674 | poliovirus receptor-related 2 (herpesvirus entry mediator B); Probable cell adhesion protein | septin 4; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli | 0.801 |
| SEPP1 | GOPC | ENSP00000420939 | ENSP00000357484 | selenoprotein P, plasma, 1; Might be responsible for some of the extracellular antioxidant defense properties of selenium or might be involved in the transport of selenium. May supply selenium to tissues such as brain and testis | golgi-associated PDZ and coiled-coil motif containing; Plays a role in intracellular protein trafficking and degradation. May regulate CFTR chloride currents and acid-induced ASIC3 currents by modulating cell surface expression of both channels. May also regulate the intracellular trafficking of the ADR1B receptor. May play a role in autophagy. Overexpression results in CFTR intracellular retention and degradation in the lysosomes | 0.801 |
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