Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | DLEU7 | deleted in lymphocytic leukemia, 7 (160 aa) | ||||||||||||
Predicted Functional Partners:
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 | FAM124A | family with sequence similarity 124A (582 aa) |
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0.555 | ||||||||||
 | ADAMTSL3 | ADAMTS-like 3 (1691 aa) |
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0.501 | ||||||||||
 | FUBP3 | far upstream element (FUSE) binding protein 3; May interact with single-stranded DNA from the far- upstream element (FUSE). May activate gene expression (572 aa) |
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0.486 | ||||||||||
 | MTMR11 | myotubularin related protein 11 (709 aa) |
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0.472 | ||||||||||
 | BCAS3 | breast carcinoma amplified sequence 3 (928 aa) |
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0.450 | ||||||||||
 | LCORL | ligand dependent nuclear receptor corepressor-like; May act as transcription activator that binds DNA elements with the sequence 5’-CCCTATCGATCGATCTCTACCT-3’. May play a role in spermatogenesis (By similarity) (602 aa) |
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0.429 | ||||||||||
 | ANAPC13 | anaphase promoting complex subunit 13; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains (74 aa) |
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0.424 | ||||||||||
 | DLEU1 | deleted in lymphocytic leukemia 1 (non-protein coding); May act as a tumor suppressor (78 aa) |
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0.418 | ||||||||||
 | CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1; Potent and specific inhibitor of CaM-kinase II (CAMK2) (By similarity) (78 aa) |
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0.412 | ||||||||||
 | UQCC | ubiquinol-cytochrome c reductase complex chaperone (299 aa) |
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0.409 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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