IGSF22 protein (Homo sapiens) - STRING network view

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IGSF22

immunoglobulin superfamily, member 22 (1326 aa)

Predicted Functional Partners:

SYT14

0.569

GPR82

0.568

CCDC90B

0.509

MEF2A

0.488

MEF2C

0.488

MEF2D

0.488

MEF2B

0.488

PREX2

0.479

SEL1L3

0.472

PHF8

0.472

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCDC90B	IGSF22	ENSP00000434724	ENSP00000421191	coiled-coil domain containing 90B	immunoglobulin superfamily, member 22	0.509
GPR82	IGSF22	ENSP00000303549	ENSP00000421191	G protein-coupled receptor 82; Orphan receptor	immunoglobulin superfamily, member 22	0.568
IGSF22	CCDC90B	ENSP00000421191	ENSP00000434724	immunoglobulin superfamily, member 22	coiled-coil domain containing 90B	0.509
IGSF22	GPR82	ENSP00000421191	ENSP00000303549	immunoglobulin superfamily, member 22	G protein-coupled receptor 82; Orphan receptor	0.568
IGSF22	MEF2A	ENSP00000421191	ENSP00000346389	immunoglobulin superfamily, member 22	myocyte enhancer factor 2A	0.488
IGSF22	MEF2B	ENSP00000421191	ENSP00000162023	immunoglobulin superfamily, member 22	myocyte enhancer factor 2B; Transcriptional activator which binds specifically to the MEF2 element, 5’-YTA[AT](4)TAR-3’, found in numerous muscle- specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription	0.488
IGSF22	MEF2C	ENSP00000421191	ENSP00000340874	immunoglobulin superfamily, member 22	myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...]	0.488
IGSF22	MEF2D	ENSP00000421191	ENSP00000271555	immunoglobulin superfamily, member 22	myocyte enhancer factor 2D; Transcriptional activator which binds specifically to the MEF2 element, 5’-YTA[AT](4)TAR-3’, found in numerous muscle- specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity)	0.488
IGSF22	PHF8	ENSP00000421191	ENSP00000350676	immunoglobulin superfamily, member 22	PHD finger protein 8	0.472
IGSF22	PREX2	ENSP00000421191	ENSP00000288368	immunoglobulin superfamily, member 22	phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2; Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein- coupled receptors and phosphoinositide 3-kinase	0.479
IGSF22	SEL1L3	ENSP00000421191	ENSP00000382767	immunoglobulin superfamily, member 22	sel-1 suppressor of lin-12-like 3 (C. elegans)	0.472
IGSF22	SYT14	ENSP00000421191	ENSP00000389039	immunoglobulin superfamily, member 22	synaptotagmin XIV	0.569
MEF2A	IGSF22	ENSP00000346389	ENSP00000421191	myocyte enhancer factor 2A	immunoglobulin superfamily, member 22	0.488
MEF2A	MEF2C	ENSP00000346389	ENSP00000340874	myocyte enhancer factor 2A	myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...]	0.904
MEF2A	MEF2D	ENSP00000346389	ENSP00000271555	myocyte enhancer factor 2A	myocyte enhancer factor 2D; Transcriptional activator which binds specifically to the MEF2 element, 5’-YTA[AT](4)TAR-3’, found in numerous muscle- specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity)	0.991
MEF2B	IGSF22	ENSP00000162023	ENSP00000421191	myocyte enhancer factor 2B; Transcriptional activator which binds specifically to the MEF2 element, 5’-YTA[AT](4)TAR-3’, found in numerous muscle- specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription	immunoglobulin superfamily, member 22	0.488
MEF2C	IGSF22	ENSP00000340874	ENSP00000421191	myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...]	immunoglobulin superfamily, member 22	0.488
MEF2C	MEF2A	ENSP00000340874	ENSP00000346389	myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...]	myocyte enhancer factor 2A	0.904
MEF2C	MEF2D	ENSP00000340874	ENSP00000271555	myocyte enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platel [...]	myocyte enhancer factor 2D; Transcriptional activator which binds specifically to the MEF2 element, 5’-YTA[AT](4)TAR-3’, found in numerous muscle- specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity)	0.956
MEF2D	IGSF22	ENSP00000271555	ENSP00000421191	myocyte enhancer factor 2D; Transcriptional activator which binds specifically to the MEF2 element, 5’-YTA[AT](4)TAR-3’, found in numerous muscle- specific, growth factor- and stress-induced genes. Mediates cellular functions not only in skeletal and cardiac muscle development, but also in neuronal differentiation and survival. Plays diverse roles in the control of cell growth, survival and apoptosis via p38 MAPK signaling in muscle-specific and/or growth factor-related transcription. Plays a critical role in the regulation of neuronal apoptosis (By similarity)	immunoglobulin superfamily, member 22	0.488

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