node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
LDLR | LRPAP1 | ENSP00000454071 | ENSP00000421922 | low density lipoprotein receptor | low density lipoprotein receptor-related protein associated protein 1; Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330 | 0.975 |
LDLR | SORT1 | ENSP00000454071 | ENSP00000256637 | low density lipoprotein receptor | sortilin 1; Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic diff [...] | 0.499 |
LRP1 | LRPAP1 | ENSP00000243077 | ENSP00000421922 | low density lipoprotein receptor-related protein 1; Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission | low density lipoprotein receptor-related protein associated protein 1; Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330 | 0.994 |
LRP2 | LRPAP1 | ENSP00000263816 | ENSP00000421922 | low density lipoprotein receptor-related protein 2; Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid- hormone and para-thyroid-hormone-related protein release | low density lipoprotein receptor-related protein associated protein 1; Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330 | 0.991 |
LRP2 | RELN | ENSP00000263816 | ENSP00000392423 | low density lipoprotein receptor-related protein 2; Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid- hormone and para-thyroid-hormone-related protein release | reelin; Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity) | 0.406 |
LRP2 | SHH | ENSP00000263816 | ENSP00000297261 | low density lipoprotein receptor-related protein 2; Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid- hormone and para-thyroid-hormone-related protein release | sonic hedgehog; Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development- signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- [...] | 0.988 |
LRP8 | LRPAP1 | ENSP00000303634 | ENSP00000421922 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the fore [...] | low density lipoprotein receptor-related protein associated protein 1; Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330 | 0.980 |
LRP8 | RAPGEF1 | ENSP00000303634 | ENSP00000361264 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the fore [...] | Rap guanine nucleotide exchange factor (GEF) 1; Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS | 0.927 |
LRP8 | RELN | ENSP00000303634 | ENSP00000392423 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the fore [...] | reelin; Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity) | 0.999 |
LRP8 | VLDLR | ENSP00000303634 | ENSP00000371532 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the fore [...] | very low density lipoprotein receptor; Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity) | 0.904 |
LRPAP1 | LDLR | ENSP00000421922 | ENSP00000454071 | low density lipoprotein receptor-related protein associated protein 1; Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330 | low density lipoprotein receptor | 0.975 |
LRPAP1 | LRP1 | ENSP00000421922 | ENSP00000243077 | low density lipoprotein receptor-related protein associated protein 1; Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330 | low density lipoprotein receptor-related protein 1; Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Required for early embryonic development. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. May modulate cellular events, such as APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling as well as neurotransmission | 0.994 |
LRPAP1 | LRP2 | ENSP00000421922 | ENSP00000263816 | low density lipoprotein receptor-related protein associated protein 1; Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330 | low density lipoprotein receptor-related protein 2; Acts together with cubilin to mediate HDL endocytosis (By similarity). May participate in regulation of parathyroid- hormone and para-thyroid-hormone-related protein release | 0.991 |
LRPAP1 | LRP8 | ENSP00000421922 | ENSP00000303634 | low density lipoprotein receptor-related protein associated protein 1; Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330 | low density lipoprotein receptor-related protein 8, apolipoprotein e receptor; Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the fore [...] | 0.980 |
LRPAP1 | RAPGEF1 | ENSP00000421922 | ENSP00000361264 | low density lipoprotein receptor-related protein associated protein 1; Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330 | Rap guanine nucleotide exchange factor (GEF) 1; Guanine nucleotide-releasing protein that binds to SH3 domain of CRK and GRB2/ASH. Transduces signals from CRK to activate RAS | 0.948 |
LRPAP1 | RELN | ENSP00000421922 | ENSP00000392423 | low density lipoprotein receptor-related protein associated protein 1; Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330 | reelin; Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity) | 0.900 |
LRPAP1 | SHH | ENSP00000421922 | ENSP00000297261 | low density lipoprotein receptor-related protein associated protein 1; Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330 | sonic hedgehog; Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development- signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior-posterior axis of the developing limb bud. Displays both floor plate- [...] | 0.901 |
LRPAP1 | SORL1 | ENSP00000421922 | ENSP00000260197 | low density lipoprotein receptor-related protein associated protein 1; Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330 | sortilin-related receptor, L(DLR class) A repeats containing; Likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. Binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. Binds the receptor- associated protein (RAP). Could play a role in cell-cell interaction | 0.928 |
LRPAP1 | SORT1 | ENSP00000421922 | ENSP00000256637 | low density lipoprotein receptor-related protein associated protein 1; Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330 | sortilin 1; Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic diff [...] | 0.917 |
LRPAP1 | VLDLR | ENSP00000421922 | ENSP00000371532 | low density lipoprotein receptor-related protein associated protein 1; Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330 | very low density lipoprotein receptor; Binds VLDL and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Binding to Reelin induces tyrosine phosphorylation of Dab1 and modulation of Tau phosphorylation (By similarity) | 0.998 |