TRIML2 protein (Homo sapiens) - STRING network view

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TRIML2

tripartite motif family-like 2 (387 aa)

Predicted Functional Partners:

TRIM31

0.585

CYP4V2

0.484

TRIM52

0.454

TRIM63

0.441

FAT1

0.407

SLC25A4

0.405

SSRP1

0.405

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CYP4V2	TRIML2	ENSP00000368079	ENSP00000422581	cytochrome P450, family 4, subfamily V, polypeptide 2; Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12). May have a role in fatty acid and steroid metabolism in the eye	tripartite motif family-like 2	0.484
FAT1	TRIML2	ENSP00000406229	ENSP00000422581	FAT tumor suppressor homolog 1 (Drosophila); Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact (By similarity)	tripartite motif family-like 2	0.407
SLC25A4	TRIML2	ENSP00000281456	ENSP00000422581	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane	tripartite motif family-like 2	0.405
SSRP1	TRIM31	ENSP00000278412	ENSP00000365924	structure specific recognition protein 1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the ree [...]	tripartite motif containing 31	0.405
SSRP1	TRIM52	ENSP00000278412	ENSP00000332152	structure specific recognition protein 1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the ree [...]	tripartite motif containing 52	0.405
SSRP1	TRIML2	ENSP00000278412	ENSP00000422581	structure specific recognition protein 1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the ree [...]	tripartite motif family-like 2	0.405
TRIM31	SSRP1	ENSP00000365924	ENSP00000278412	tripartite motif containing 31	structure specific recognition protein 1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the ree [...]	0.405
TRIM31	TRIML2	ENSP00000365924	ENSP00000422581	tripartite motif containing 31	tripartite motif family-like 2	0.585
TRIM52	SSRP1	ENSP00000332152	ENSP00000278412	tripartite motif containing 52	structure specific recognition protein 1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the ree [...]	0.405
TRIM52	TRIML2	ENSP00000332152	ENSP00000422581	tripartite motif containing 52	tripartite motif family-like 2	0.454
TRIM63	TRIML2	ENSP00000363390	ENSP00000422581	tripartite motif containing 63, E3 ubiquitin protein ligase; E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertroph [...]	tripartite motif family-like 2	0.441
TRIML2	CYP4V2	ENSP00000422581	ENSP00000368079	tripartite motif family-like 2	cytochrome P450, family 4, subfamily V, polypeptide 2; Catalyzes the omega-hydroxylation of medium-chain saturated fatty acids such as laurate, myristate and palmitate in an NADPH-dependent pathway. The substrate specificity is higher for myristate > laurate > palmitate (C14>C16>C12). May have a role in fatty acid and steroid metabolism in the eye	0.484
TRIML2	FAT1	ENSP00000422581	ENSP00000406229	tripartite motif family-like 2	FAT tumor suppressor homolog 1 (Drosophila); Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact (By similarity)	0.407
TRIML2	SLC25A4	ENSP00000422581	ENSP00000281456	tripartite motif family-like 2	solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane	0.405
TRIML2	SSRP1	ENSP00000422581	ENSP00000278412	tripartite motif family-like 2	structure specific recognition protein 1; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the ree [...]	0.405
TRIML2	TRIM31	ENSP00000422581	ENSP00000365924	tripartite motif family-like 2	tripartite motif containing 31	0.585
TRIML2	TRIM52	ENSP00000422581	ENSP00000332152	tripartite motif family-like 2	tripartite motif containing 52	0.454
TRIML2	TRIM63	ENSP00000422581	ENSP00000363390	tripartite motif family-like 2	tripartite motif containing 63, E3 ubiquitin protein ligase; E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertroph [...]	0.441

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