| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FGFR1OP | FOXP1 | ENSP00000355812 | ENSP00000318902 | FGFR1 oncogene partner; Required for anchoring microtubules to the centrosomes | forkhead box P1; Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development (By similarity) | 0.590 |
| FGFR1OP | RNASET2 | ENSP00000355812 | ENSP00000422846 | FGFR1 oncogene partner; Required for anchoring microtubules to the centrosomes | ribonuclease T2; Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism | 0.800 |
| FOXP1 | FGFR1OP | ENSP00000318902 | ENSP00000355812 | forkhead box P1; Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development (By similarity) | FGFR1 oncogene partner; Required for anchoring microtubules to the centrosomes | 0.590 |
| FOXP1 | RNASET2 | ENSP00000318902 | ENSP00000422846 | forkhead box P1; Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development (By similarity) | ribonuclease T2; Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism | 0.680 |
| KTI12 | RNASET2 | ENSP00000360676 | ENSP00000422846 | KTI12 homolog, chromatin associated (S. cerevisiae) | ribonuclease T2; Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism | 0.614 |
| MRPL12 | NIT2 | ENSP00000333837 | ENSP00000377696 | mitochondrial ribosomal protein L12 | nitrilase family, member 2; Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha- ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively. Overexpression decreases the colony-forming capacity of cultured cells by arresting cells in the G2 phase of the cell cycle | 0.666 |
| MRPL12 | PUS1 | ENSP00000333837 | ENSP00000365837 | mitochondrial ribosomal protein L12 | pseudouridylate synthase 1; Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA (By similarity) | 0.454 |
| MRPL12 | RNASET2 | ENSP00000333837 | ENSP00000422846 | mitochondrial ribosomal protein L12 | ribonuclease T2; Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism | 0.858 |
| MRPL12 | SUCLG2 | ENSP00000333837 | ENSP00000419325 | mitochondrial ribosomal protein L12 | succinate-CoA ligase, GDP-forming, beta subunit; Catalyzes the GTP-dependent ligation of succinate and CoA to form succinyl-CoA (By similarity) | 0.749 |
| NDUFV1 | RNASET2 | ENSP00000322450 | ENSP00000422846 | NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity) | ribonuclease T2; Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism | 0.644 |
| NIT2 | MRPL12 | ENSP00000377696 | ENSP00000333837 | nitrilase family, member 2; Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha- ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively. Overexpression decreases the colony-forming capacity of cultured cells by arresting cells in the G2 phase of the cell cycle | mitochondrial ribosomal protein L12 | 0.666 |
| NIT2 | RNASET2 | ENSP00000377696 | ENSP00000422846 | nitrilase family, member 2; Has a omega-amidase activity. The role of omega-amidase is to remove potentially toxic intermediates by converting alpha- ketoglutaramate and alpha-ketosuccinamate to biologically useful alpha-ketoglutarate and oxaloacetate, respectively. Overexpression decreases the colony-forming capacity of cultured cells by arresting cells in the G2 phase of the cell cycle | ribonuclease T2; Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism | 0.907 |
| PRDX3 | RNASET2 | ENSP00000298510 | ENSP00000422846 | peroxiredoxin 3; Involved in redox regulation of the cell. Protects radical-sensitive enzymes from oxidative damage by a radical- generating system. Acts synergistically with MAP3K13 to regulate the activation of NF-kappa-B in the cytosol | ribonuclease T2; Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism | 0.662 |
| PUS1 | MRPL12 | ENSP00000365837 | ENSP00000333837 | pseudouridylate synthase 1; Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA (By similarity) | mitochondrial ribosomal protein L12 | 0.454 |
| PUS1 | RNASET2 | ENSP00000365837 | ENSP00000422846 | pseudouridylate synthase 1; Converts specific uridines to PSI in a number of tRNA substrates. Acts on positions 27/28 in the anticodon stem and also positions 34 and 36 in the anticodon of an intron containing tRNA. Involved in regulation of nuclear receptor activity possibly through pseudouridylation of SRA1 RNA (By similarity) | ribonuclease T2; Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism | 0.653 |
| RNASET2 | FGFR1OP | ENSP00000422846 | ENSP00000355812 | ribonuclease T2; Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism | FGFR1 oncogene partner; Required for anchoring microtubules to the centrosomes | 0.800 |
| RNASET2 | FOXP1 | ENSP00000422846 | ENSP00000318902 | ribonuclease T2; Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism | forkhead box P1; Transcriptional repressor. It plays an important role in the specification and differentiation of lung epithelium. Can act with CTBP1 to synergistically repress transcription but CTPBP1 is not essential. Essential transcriptional regulator of B-cell development (By similarity) | 0.680 |
| RNASET2 | KTI12 | ENSP00000422846 | ENSP00000360676 | ribonuclease T2; Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism | KTI12 homolog, chromatin associated (S. cerevisiae) | 0.614 |
| RNASET2 | MRPL12 | ENSP00000422846 | ENSP00000333837 | ribonuclease T2; Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism | mitochondrial ribosomal protein L12 | 0.858 |
| RNASET2 | NDUFV1 | ENSP00000422846 | ENSP00000322450 | ribonuclease T2; Has ribonuclease activity, with higher activity at acidic pH. Probably is involved in lysosomal degradation of ribosomal RNA (By similarity). Probably plays a role in cellular RNA catabolism | NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity) | 0.644 |
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