MTX3 protein (Homo sapiens) - STRING network view

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Score

MTX3

metaxin 3; Could function in transport of proteins into the mitochondrion (By similarity) (251 aa)

Predicted Functional Partners:

SAMM50

0.950

TOMM40L

0.862

TOMM40

0.862

TOMM20

0.778

TOMM20L

0.778

TOMM70A

0.738

TOMM22

0.673

UBC

0.642

C1orf116

0.637

DHFR

0.610

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
C1orf116	MTX3	ENSP00000352447	ENSP00000423600	chromosome 1 open reading frame 116; Putative androgen-specific receptor	metaxin 3; Could function in transport of proteins into the mitochondrion (By similarity)	0.637
DHFR	MTX3	ENSP00000396308	ENSP00000423600	dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1	metaxin 3; Could function in transport of proteins into the mitochondrion (By similarity)	0.610
DHFR	TOMM20	ENSP00000396308	ENSP00000355566	dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1	translocase of outer mitochondrial membrane 20 homolog (yeast); Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity)	0.829
DHFR	TOMM22	ENSP00000396308	ENSP00000216034	dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1	translocase of outer mitochondrial membrane 22 homolog (yeast); Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore	0.432
DHFR	TOMM40	ENSP00000396308	ENSP00000252487	dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1	translocase of outer mitochondrial membrane 40 homolog (yeast); Channel-forming protein essential for import of protein precursors into mitochondria (By similarity)	0.678
DHFR	TOMM70A	ENSP00000396308	ENSP00000284320	dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1	translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae); Receptor that accelerates the import of all mitochondrial precursor proteins (By similarity)	0.582
DHFR	UBC	ENSP00000396308	ENSP00000344818	dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1	ubiquitin C	0.960
MTX3	C1orf116	ENSP00000423600	ENSP00000352447	metaxin 3; Could function in transport of proteins into the mitochondrion (By similarity)	chromosome 1 open reading frame 116; Putative androgen-specific receptor	0.637
MTX3	DHFR	ENSP00000423600	ENSP00000396308	metaxin 3; Could function in transport of proteins into the mitochondrion (By similarity)	dihydrofolate reductase; Key enzyme in folate metabolism. Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. Binds its own mRNA and that of DHFRL1	0.610
MTX3	SAMM50	ENSP00000423600	ENSP00000345445	metaxin 3; Could function in transport of proteins into the mitochondrion (By similarity)	sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity)	0.950
MTX3	TOMM20	ENSP00000423600	ENSP00000355566	metaxin 3; Could function in transport of proteins into the mitochondrion (By similarity)	translocase of outer mitochondrial membrane 20 homolog (yeast); Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity)	0.778
MTX3	TOMM20L	ENSP00000423600	ENSP00000354204	metaxin 3; Could function in transport of proteins into the mitochondrion (By similarity)	translocase of outer mitochondrial membrane 20 homolog (yeast)-like	0.778
MTX3	TOMM22	ENSP00000423600	ENSP00000216034	metaxin 3; Could function in transport of proteins into the mitochondrion (By similarity)	translocase of outer mitochondrial membrane 22 homolog (yeast); Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM20 functions as the transit peptide receptor and facilitates the movement of preproteins into the translocation pore	0.673
MTX3	TOMM40	ENSP00000423600	ENSP00000252487	metaxin 3; Could function in transport of proteins into the mitochondrion (By similarity)	translocase of outer mitochondrial membrane 40 homolog (yeast); Channel-forming protein essential for import of protein precursors into mitochondria (By similarity)	0.862
MTX3	TOMM40L	ENSP00000423600	ENSP00000356966	metaxin 3; Could function in transport of proteins into the mitochondrion (By similarity)	translocase of outer mitochondrial membrane 40 homolog (yeast)-like; Potential channel-forming protein implicated in import of protein precursors into mitochondria (By similarity)	0.862
MTX3	TOMM70A	ENSP00000423600	ENSP00000284320	metaxin 3; Could function in transport of proteins into the mitochondrion (By similarity)	translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae); Receptor that accelerates the import of all mitochondrial precursor proteins (By similarity)	0.738
MTX3	UBC	ENSP00000423600	ENSP00000344818	metaxin 3; Could function in transport of proteins into the mitochondrion (By similarity)	ubiquitin C	0.642
SAMM50	MTX3	ENSP00000345445	ENSP00000423600	sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity)	metaxin 3; Could function in transport of proteins into the mitochondrion (By similarity)	0.950
SAMM50	TOMM20	ENSP00000345445	ENSP00000355566	sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity)	translocase of outer mitochondrial membrane 20 homolog (yeast); Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity)	0.989
SAMM50	TOMM20L	ENSP00000345445	ENSP00000354204	sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity)	translocase of outer mitochondrial membrane 20 homolog (yeast)-like	0.619

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