| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ATP7A | SH3TC2 | ENSP00000345728 | ENSP00000423660 | ATPase, Cu++ transporting, alpha polypeptide; May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells | SH3 domain and tetratricopeptide repeats 2 | 0.537 |
| CTDP1 | GDAP1 | ENSP00000299543 | ENSP00000220822 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1; Processively dephosphorylates ’Ser-2’ and ’Ser-5’ of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation | ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission | 0.416 |
| CTDP1 | NDRG1 | ENSP00000299543 | ENSP00000319977 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1; Processively dephosphorylates ’Ser-2’ and ’Ser-5’ of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation | N-myc downstream regulated 1; Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle c [...] | 0.750 |
| CTDP1 | SBF2 | ENSP00000299543 | ENSP00000256190 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1; Processively dephosphorylates ’Ser-2’ and ’Ser-5’ of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation | SET binding factor 2 | 0.442 |
| CTDP1 | SH3TC2 | ENSP00000299543 | ENSP00000423660 | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1; Processively dephosphorylates ’Ser-2’ and ’Ser-5’ of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation | SH3 domain and tetratricopeptide repeats 2 | 0.608 |
| FGD4 | GDAP1 | ENSP00000394487 | ENSP00000220822 | FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity) | ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission | 0.750 |
| FGD4 | MPZ | ENSP00000394487 | ENSP00000431538 | FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity) | myelin protein zero; Creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae | 0.414 |
| FGD4 | MTMR2 | ENSP00000394487 | ENSP00000345752 | FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity) | myotubularin related protein 2; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate | 0.512 |
| FGD4 | NDRG1 | ENSP00000394487 | ENSP00000319977 | FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity) | N-myc downstream regulated 1; Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle c [...] | 0.742 |
| FGD4 | SBF2 | ENSP00000394487 | ENSP00000256190 | FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity) | SET binding factor 2 | 0.685 |
| FGD4 | SH3TC2 | ENSP00000394487 | ENSP00000423660 | FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity) | SH3 domain and tetratricopeptide repeats 2 | 0.748 |
| GDAP1 | CTDP1 | ENSP00000220822 | ENSP00000299543 | ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission | CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1; Processively dephosphorylates ’Ser-2’ and ’Ser-5’ of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit. This promotes the activity of RNA polymerase II. Plays a role in the exit from mitosis by dephosphorylating crucial mitotic substrates (USP44, CDC20 and WEE1) that are required for M-phase-promoting factor (MPF)/CDK1 inactivation | 0.416 |
| GDAP1 | FGD4 | ENSP00000220822 | ENSP00000394487 | ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission | FYVE, RhoGEF and PH domain containing 4; Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Plays a role in regulating the actin cytoskeleton and cell shape. Activates MAPK8 (By similarity) | 0.750 |
| GDAP1 | MPZ | ENSP00000220822 | ENSP00000431538 | ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission | myelin protein zero; Creation of an extracellular membrane face which guides the wrapping process and ultimately compacts adjacent lamellae | 0.870 |
| GDAP1 | MTMR2 | ENSP00000220822 | ENSP00000345752 | ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission | myotubularin related protein 2; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate | 0.725 |
| GDAP1 | NDRG1 | ENSP00000220822 | ENSP00000319977 | ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission | N-myc downstream regulated 1; Stress-responsive protein involved in hormone responses, cell growth, and differentiation. Acts as a tumor suppressor in many cell types. Necessary but not sufficient for p53/TP53- mediated caspase activation and apoptosis. Has a role in cell trafficking, notably of the Schwann cell, and is necessary for the maintenance and development of the peripheral nerve myelin sheath. Required for vesicular recycling of CDH1 and TF. May also function in lipid trafficking. Protects cells from spindle disruption damage. Functions in p53/TP53-dependent mitotic spindle c [...] | 0.756 |
| GDAP1 | PMP22 | ENSP00000220822 | ENSP00000308937 | ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission | peripheral myelin protein 22; Might be involved in growth regulation, and in myelinization in the peripheral nervous system | 0.749 |
| GDAP1 | SBF2 | ENSP00000220822 | ENSP00000256190 | ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission | SET binding factor 2 | 0.728 |
| GDAP1 | SH3TC2 | ENSP00000220822 | ENSP00000423660 | ganglioside induced differentiation associated protein 1; Regulates the mitochondrial network by promoting mitochondrial fission | SH3 domain and tetratricopeptide repeats 2 | 0.749 |
| KRT86 | SH3TC2 | ENSP00000452237 | ENSP00000423660 | keratin 86 | SH3 domain and tetratricopeptide repeats 2 | 0.505 |
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