USP17L23 protein (Homo sapiens) - STRING network view

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USP17L23

ubiquitin specific peptidase 17-like family member 23 (183 aa)

Predicted Functional Partners:

ORC1

0.670

USP43

0.605

USP3

0.597

USP49

0.597

USP44

0.597

USP30

0.597

RNF20

0.582

RNF40

0.582

USP50

0.495

USP26

0.495

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ORC1	USP17L23	ENSP00000360621	ENSP00000424077	origin recognition complex, subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication	ubiquitin specific peptidase 17-like family member 23	0.670
RNF20	RNF40	ENSP00000373772	ENSP00000325677	ring finger protein 20, E3 ubiquitin protein ligase	ring finger protein 40, E3 ubiquitin protein ligase; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of ’Lys-120’ of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 ’Lys-4’ and ’Lys-79’ methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/ [...]	0.997
RNF20	USP17L23	ENSP00000373772	ENSP00000424077	ring finger protein 20, E3 ubiquitin protein ligase	ubiquitin specific peptidase 17-like family member 23	0.582
RNF20	USP3	ENSP00000373772	ENSP00000369681	ring finger protein 20, E3 ubiquitin protein ligase	ubiquitin specific peptidase 3; Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin	0.669
RNF20	USP30	ENSP00000373772	ENSP00000257548	ring finger protein 20, E3 ubiquitin protein ligase	ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology	0.545
RNF20	USP44	ENSP00000373772	ENSP00000258499	ring finger protein 20, E3 ubiquitin protein ligase	ubiquitin specific peptidase 44; Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a neg [...]	0.709
RNF20	USP49	ENSP00000373772	ENSP00000297229	ring finger protein 20, E3 ubiquitin protein ligase	ubiquitin specific peptidase 49	0.545
RNF40	RNF20	ENSP00000325677	ENSP00000373772	ring finger protein 40, E3 ubiquitin protein ligase; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of ’Lys-120’ of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 ’Lys-4’ and ’Lys-79’ methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/ [...]	ring finger protein 20, E3 ubiquitin protein ligase	0.997
RNF40	USP17L23	ENSP00000325677	ENSP00000424077	ring finger protein 40, E3 ubiquitin protein ligase; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of ’Lys-120’ of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 ’Lys-4’ and ’Lys-79’ methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/ [...]	ubiquitin specific peptidase 17-like family member 23	0.582
RNF40	USP3	ENSP00000325677	ENSP00000369681	ring finger protein 40, E3 ubiquitin protein ligase; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of ’Lys-120’ of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 ’Lys-4’ and ’Lys-79’ methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/ [...]	ubiquitin specific peptidase 3; Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin	0.561
RNF40	USP30	ENSP00000325677	ENSP00000257548	ring finger protein 40, E3 ubiquitin protein ligase; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of ’Lys-120’ of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 ’Lys-4’ and ’Lys-79’ methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/ [...]	ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology	0.545
RNF40	USP44	ENSP00000325677	ENSP00000258499	ring finger protein 40, E3 ubiquitin protein ligase; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of ’Lys-120’ of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 ’Lys-4’ and ’Lys-79’ methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/ [...]	ubiquitin specific peptidase 44; Deubiquitinase that plays a key regulatory role in the spindle assembly checkpoint or mitotic checkpoint by preventing premature anaphase onset. Acts by specifically mediating deubiquitination of CDC20, a negative regulator of the anaphase promoting complex/cyclosome (APC/C). Deubiquitination of CDC20 leads to stabilize the MAD2L1-CDC20-APC/C ternary complex (also named mitotic checkpoint complex), thereby preventing premature activation of the APC/C. Promotes association of MAD2L1 with CDC20 and reinforces the spindle assembly checkpoint. Acts as a neg [...]	0.546
RNF40	USP49	ENSP00000325677	ENSP00000297229	ring finger protein 40, E3 ubiquitin protein ligase; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of ’Lys-120’ of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 ’Lys-4’ and ’Lys-79’ methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/ [...]	ubiquitin specific peptidase 49	0.547
USP17L23	ORC1	ENSP00000424077	ENSP00000360621	ubiquitin specific peptidase 17-like family member 23	origin recognition complex, subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication	0.670
USP17L23	RNF20	ENSP00000424077	ENSP00000373772	ubiquitin specific peptidase 17-like family member 23	ring finger protein 20, E3 ubiquitin protein ligase	0.582
USP17L23	RNF40	ENSP00000424077	ENSP00000325677	ubiquitin specific peptidase 17-like family member 23	ring finger protein 40, E3 ubiquitin protein ligase; Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of ’Lys-120’ of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 ’Lys-4’ and ’Lys-79’ methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/ [...]	0.582
USP17L23	USP26	ENSP00000424077	ENSP00000359869	ubiquitin specific peptidase 17-like family member 23	ubiquitin specific peptidase 26; Involved in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasome (By similarity). Deubiquitinates the androgen receptor and regulates the androgen receptor signaling pathway	0.495
USP17L23	USP3	ENSP00000424077	ENSP00000369681	ubiquitin specific peptidase 17-like family member 23	ubiquitin specific peptidase 3; Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin	0.597
USP17L23	USP30	ENSP00000424077	ENSP00000257548	ubiquitin specific peptidase 17-like family member 23	ubiquitin specific peptidase 30; May participate in the maintenance of mitochondrial morphology	0.597
USP17L23	USP43	ENSP00000424077	ENSP00000285199	ubiquitin specific peptidase 17-like family member 23	ubiquitin specific peptidase 43; May recognize and hydrolyze the peptide bond at the C- terminal Gly of ubiquitin. Involved in the processing of poly- ubiquitin precursors as well as that of ubiquitinated proteins (By similarity)	0.605

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