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STRINGSTRING
TBCD TBCD WFDC10B WFDC10B TPD52L1 TPD52L1 SPAM1 SPAM1 ADAM2 ADAM2 ENSG00000249139 ENSG00000249139 FSTL5 FSTL5 SPINT4 SPINT4 SEMG2 SEMG2 RNASE10 RNASE10 CST11 CST11
"ENSG00000249139" - EPPIN-WFDC6 readthrough in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSG00000249139EPPIN-WFDC6 readthrough (179 aa)    
Predicted Functional Partners:
WFDC10B
WAP four-disulfide core domain 10B (89 aa)
             score_image   0.658
TPD52L1
tumor protein D52-like 1 (204 aa)
             score_image   0.601
CST11
cystatin 11; Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization (138 aa)
             score_image   0.581
SPAM1
sperm adhesion molecule 1 (PH-20 hyaluronidase, zona pellucida binding); Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid (511 aa)
             score_image   0.562
SPINT4
serine peptidase inhibitor, Kunitz type 4 (99 aa)
             score_image   0.538
SEMG2
semenogelin II; Participates in the formation of a gel matrix (sperm coagulum) entrapping the accessory gland secretions and ejaculated spermatozoa (582 aa)
             score_image   0.508
RNASE10
ribonuclease, RNase A family, 10 (non-active); Not known; does not have ribonuclease activity (By similarity) (216 aa)
             score_image   0.480
FSTL5
follistatin-like 5 (847 aa)
             score_image   0.475
ADAM2
ADAM metallopeptidase domain 2; Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein (735 aa)
             score_image   0.474
TBCD
tubulin folding cofactor D (1192 aa)
             score_image   0.473
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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