node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ELOVL4 | EYS | ENSP00000358831 | ENSP00000424243 | ELOVL fatty acid elongase 4; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs). Elongates C24-0 and C26-0 acyl-CoAs. Seems to represent a photoreceptor- specific component of the fatty acid elongation system residing on the endoplasmic reticulum. May be implicated in docosahexaenoic acid (DHA) biosynthesis, which requires dietary consumption of the essential alpha-linolenic acid and a subsequent series of three elongation steps. May play a critical role in early brain and skin development | eyes shut homolog (Drosophila) | 0.610 |
EYS | ELOVL4 | ENSP00000424243 | ENSP00000358831 | eyes shut homolog (Drosophila) | ELOVL fatty acid elongase 4; Condensing enzyme that elongates saturated and monounsaturated very long chain fatty acids (VLCFAs). Elongates C24-0 and C26-0 acyl-CoAs. Seems to represent a photoreceptor- specific component of the fatty acid elongation system residing on the endoplasmic reticulum. May be implicated in docosahexaenoic acid (DHA) biosynthesis, which requires dietary consumption of the essential alpha-linolenic acid and a subsequent series of three elongation steps. May play a critical role in early brain and skin development | 0.610 |
EYS | FGF12 | ENSP00000424243 | ENSP00000413496 | eyes shut homolog (Drosophila) | fibroblast growth factor 12; Probably involved in nervous system development and function | 0.597 |
EYS | FGF13 | ENSP00000424243 | ENSP00000359635 | eyes shut homolog (Drosophila) | fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus | 0.597 |
EYS | FGF14 | ENSP00000424243 | ENSP00000365301 | eyes shut homolog (Drosophila) | fibroblast growth factor 14; Probably involved in nervous system development and function | 0.597 |
EYS | FGF16 | ENSP00000424243 | ENSP00000399324 | eyes shut homolog (Drosophila) | fibroblast growth factor 16 | 0.597 |
EYS | FGF17 | ENSP00000424243 | ENSP00000352414 | eyes shut homolog (Drosophila) | fibroblast growth factor 17; Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development | 0.597 |
EYS | FGF9 | ENSP00000424243 | ENSP00000371790 | eyes shut homolog (Drosophila) | fibroblast growth factor 9 (glia-activating factor); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. May have a role in glial cell growth and differentiation during development, gliosis during repair and regeneration of brain tissue after damage, differentiation and survival of neuronal cells, and growth stimulation of glial tumors | 0.599 |
EYS | GABRR1 | ENSP00000424243 | ENSP00000412673 | eyes shut homolog (Drosophila) | gamma-aminobutyric acid (GABA) A receptor, rho 1; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-1 GABA receptor could play a role in retinal neurotransmission | 0.749 |
EYS | GABRR2 | ENSP00000424243 | ENSP00000386029 | eyes shut homolog (Drosophila) | gamma-aminobutyric acid (GABA) A receptor, rho 2; GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Rho-2 GABA receptor could play a role in retinal neurotransmission | 0.748 |
EYS | LAMC1 | ENSP00000424243 | ENSP00000258341 | eyes shut homolog (Drosophila) | laminin, gamma 1 (formerly LAMB2); Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components | 0.635 |
FGF12 | EYS | ENSP00000413496 | ENSP00000424243 | fibroblast growth factor 12; Probably involved in nervous system development and function | eyes shut homolog (Drosophila) | 0.597 |
FGF12 | FGF17 | ENSP00000413496 | ENSP00000352414 | fibroblast growth factor 12; Probably involved in nervous system development and function | fibroblast growth factor 17; Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development | 0.612 |
FGF13 | EYS | ENSP00000359635 | ENSP00000424243 | fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus | eyes shut homolog (Drosophila) | 0.597 |
FGF13 | FGF17 | ENSP00000359635 | ENSP00000352414 | fibroblast growth factor 13; Microtubule-binding protein which directly binds tubulin and is involved in both polymerization and stabilization of microtubules. Through its action on microtubules, may participate to the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarization and migration in the cerebral cortex and the hippocampus | fibroblast growth factor 17; Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development | 0.563 |
FGF14 | EYS | ENSP00000365301 | ENSP00000424243 | fibroblast growth factor 14; Probably involved in nervous system development and function | eyes shut homolog (Drosophila) | 0.597 |
FGF14 | FGF17 | ENSP00000365301 | ENSP00000352414 | fibroblast growth factor 14; Probably involved in nervous system development and function | fibroblast growth factor 17; Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development | 0.614 |
FGF16 | EYS | ENSP00000399324 | ENSP00000424243 | fibroblast growth factor 16 | eyes shut homolog (Drosophila) | 0.597 |
FGF17 | EYS | ENSP00000352414 | ENSP00000424243 | fibroblast growth factor 17; Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development | eyes shut homolog (Drosophila) | 0.597 |
FGF17 | FGF12 | ENSP00000352414 | ENSP00000413496 | fibroblast growth factor 17; Plays an important role in the regulation of embryonic development and as signaling molecule in the induction and patterning of the embryonic brain. Required for normal brain development | fibroblast growth factor 12; Probably involved in nervous system development and function | 0.612 |