SAMD14 protein (Homo sapiens) - STRING network view

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SAMD14

sterile alpha motif domain containing 14 (445 aa)

Predicted Functional Partners:

LRRC42

0.635

ARHGEF2

0.612

TIAM2

0.581

TIAM1

0.581

ANKRD40

0.505

TTLL6

0.472

WFIKKN2

0.472

TMEM144

0.471

TAC4

0.469

RNF152

0.418

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD40	SAMD14	ENSP00000285243	ENSP00000424474	ankyrin repeat domain 40	sterile alpha motif domain containing 14	0.505
ANKRD40	TAC4	ENSP00000285243	ENSP00000334042	ankyrin repeat domain 40	tachykinin 4 (hemokinin); Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin- C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility	0.459
ANKRD40	TTLL6	ENSP00000285243	ENSP00000377043	ankyrin repeat domain 40	tubulin tyrosine ligase-like family, member 6	0.471
ANKRD40	WFIKKN2	ENSP00000285243	ENSP00000311184	ankyrin repeat domain 40	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity)	0.472
ARHGEF2	SAMD14	ENSP00000354837	ENSP00000424474	Rho/Rac guanine nucleotide exchange factor (GEF) 2; Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed-9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras- GTPases. Forms an intracellular sensing sys [...]	sterile alpha motif domain containing 14	0.612
LRRC42	SAMD14	ENSP00000318185	ENSP00000424474	leucine rich repeat containing 42	sterile alpha motif domain containing 14	0.635
LRRC42	TMEM144	ENSP00000318185	ENSP00000296529	leucine rich repeat containing 42	transmembrane protein 144	0.581
RNF152	SAMD14	ENSP00000316628	ENSP00000424474	ring finger protein 152; E3 ubiquitin-protein ligase mediating ’Lys-48’-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed	sterile alpha motif domain containing 14	0.418
SAMD14	ANKRD40	ENSP00000424474	ENSP00000285243	sterile alpha motif domain containing 14	ankyrin repeat domain 40	0.505
SAMD14	ARHGEF2	ENSP00000424474	ENSP00000354837	sterile alpha motif domain containing 14	Rho/Rac guanine nucleotide exchange factor (GEF) 2; Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed-9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras- GTPases. Forms an intracellular sensing sys [...]	0.612
SAMD14	LRRC42	ENSP00000424474	ENSP00000318185	sterile alpha motif domain containing 14	leucine rich repeat containing 42	0.635
SAMD14	RNF152	ENSP00000424474	ENSP00000316628	sterile alpha motif domain containing 14	ring finger protein 152; E3 ubiquitin-protein ligase mediating ’Lys-48’-linked polyubiquitination of target proteins and their subsequent targeting to the proteasome for degradation. Induces apoptosis when overexpressed	0.418
SAMD14	TAC4	ENSP00000424474	ENSP00000334042	sterile alpha motif domain containing 14	tachykinin 4 (hemokinin); Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin- C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility	0.469
SAMD14	TIAM1	ENSP00000424474	ENSP00000286827	sterile alpha motif domain containing 14	T-cell lymphoma invasion and metastasis 1; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA	0.581
SAMD14	TIAM2	ENSP00000424474	ENSP00000327315	sterile alpha motif domain containing 14	T-cell lymphoma invasion and metastasis 2; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Mediates extracellular laminin signals to activate Rac1, contributing to neurite growth. Involved in lamellipodial formation and advancement of the growth cone of embryonic hippocampal neurons. Promotes migration of neurons in the cerebral cortex. When overexpressed, induces membrane ruffling accompanied by [...]	0.581
SAMD14	TMEM144	ENSP00000424474	ENSP00000296529	sterile alpha motif domain containing 14	transmembrane protein 144	0.471
SAMD14	TTLL6	ENSP00000424474	ENSP00000377043	sterile alpha motif domain containing 14	tubulin tyrosine ligase-like family, member 6	0.472
SAMD14	WFIKKN2	ENSP00000424474	ENSP00000311184	sterile alpha motif domain containing 14	WAP, follistatin/kazal, immunoglobulin, kunitz and netrin domain containing 2; Protease-inhibitor that contains multiple distinct protease inhibitor domains. Probably has serine protease- and metalloprotease-inhibitor activity. Inhibits the biological activity of mature myostatin, but not activin (By similarity)	0.472
TAC4	ANKRD40	ENSP00000334042	ENSP00000285243	tachykinin 4 (hemokinin); Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin- C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility	ankyrin repeat domain 40	0.459
TAC4	SAMD14	ENSP00000334042	ENSP00000424474	tachykinin 4 (hemokinin); Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. Endokinin-A induces thermal hyperalgesia and pain-related behavior such as scratching following intrathecal administration in rats. These effects are suppressed by treatment with endokinin- C. Endokinin-A/B reduces arterial blood pressure and increases sperm motility	sterile alpha motif domain containing 14	0.469

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