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STRINGSTRING
ADPRM ADPRM NUDT5 NUDT5 PGM1 PGM1 RPIA RPIA PGM2 PGM2 TKT TKT PRPS1L1 PRPS1L1 TKTL2 TKTL2 UMPS UMPS RBKS RBKS PPAT PPAT
"PRPS1L1" - phosphoribosyl pyrophosphate synthetase 1-like 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Cooccurence
Coexpression
Experiments
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[Homology]
Score
PRPS1L1phosphoribosyl pyrophosphate synthetase 1-like 1; Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis (318 aa)    
Predicted Functional Partners:
UMPS
uridine monophosphate synthetase (480 aa)
      score_image   score_image score_image   0.955
PPAT
phosphoribosyl pyrophosphate amidotransferase (517 aa)
      score_image   score_image score_image   0.937
RBKS
ribokinase (322 aa)
        score_image score_image score_image   0.932
RPIA
ribose 5-phosphate isomerase A (311 aa)
      score_image   score_image score_image   0.929
TKT
transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (623 aa)
      score_image   score_image score_image   0.927
PGM2
phosphoglucomutase 2; Catalyzes the conversion of the nucleoside breakdown products ribose-1-phosphate and deoxyribose-1-phosphate to the corresponding 5-phosphopentoses. May also catalyze the interconversion of glucose-1-phosphate and glucose-6-phosphate. Has low glucose 1,6-bisphosphate synthase activity (612 aa)
          score_image score_image   0.925
TKTL2
transketolase-like 2; Plays an essential role in total transketolase activity and cell proliferation in cancer cells; after transfection with anti-TKTL1 siRNA, total transketolase activity dramatically decreases and proliferation was significantly inhibited in cancer cells. Plays a pivotal role in carcinogenesis (626 aa)
      score_image   score_image score_image   0.915
NUDT5
nudix (nucleoside diphosphate linked moiety X)-type motif 5; Hydrolyzes with similar activities ADP-ribose ADP- mannose, ADP-glucose, 8-oxo-GDP and 8-oxo-dGDP. Can also hydrolyze other nucleotide sugars with low activity. Does not play a role in U8 snoRNA decapping activity. Binds U8 snoRNA (219 aa)
      score_image   score_image score_image   0.909
PGM1
phosphoglucomutase 1 (580 aa)
          score_image score_image   0.903
ADPRM
ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent; Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP- choline and CDP-ethanolamine, but not other non-reducing ADP- sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress (By similarity) (342 aa)
          score_image     0.900
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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