node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATRX | NEK1 | ENSP00000362441 | ENSP00000424757 | alpha thalassemia/mental retardation syndrome X-linked | NIMA-related kinase 1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly | 0.657 |
ATRX | XRCC5 | ENSP00000362441 | ENSP00000375977 | alpha thalassemia/mental retardation syndrome X-linked | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining); Single stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3’-5’ direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase [...] | 0.763 |
DYNC2H1 | KIF3A | ENSP00000381167 | ENSP00000368020 | dynein, cytoplasmic 2, heavy chain 1 | kinesin family member 3A; Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (By similarity) | 0.820 |
DYNC2H1 | NEK1 | ENSP00000381167 | ENSP00000424757 | dynein, cytoplasmic 2, heavy chain 1 | NIMA-related kinase 1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly | 0.888 |
FEZ1 | FEZ2 | ENSP00000278919 | ENSP00000368547 | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity) | 0.486 |
FEZ1 | KIF3A | ENSP00000278919 | ENSP00000368020 | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | kinesin family member 3A; Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (By similarity) | 0.829 |
FEZ1 | NEK1 | ENSP00000278919 | ENSP00000424757 | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | NIMA-related kinase 1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly | 0.682 |
FEZ2 | FEZ1 | ENSP00000368547 | ENSP00000278919 | fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity) | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | 0.486 |
FEZ2 | KIF3A | ENSP00000368547 | ENSP00000368020 | fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity) | kinesin family member 3A; Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (By similarity) | 0.638 |
FEZ2 | NEK1 | ENSP00000368547 | ENSP00000424757 | fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity) | NIMA-related kinase 1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly | 0.693 |
KIF3A | DYNC2H1 | ENSP00000368020 | ENSP00000381167 | kinesin family member 3A; Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (By similarity) | dynein, cytoplasmic 2, heavy chain 1 | 0.820 |
KIF3A | FEZ1 | ENSP00000368020 | ENSP00000278919 | kinesin family member 3A; Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (By similarity) | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | 0.829 |
KIF3A | FEZ2 | ENSP00000368020 | ENSP00000368547 | kinesin family member 3A; Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (By similarity) | fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity) | 0.638 |
KIF3A | NEK1 | ENSP00000368020 | ENSP00000424757 | kinesin family member 3A; Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (By similarity) | NIMA-related kinase 1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly | 0.803 |
KIF3A | VHL | ENSP00000368020 | ENSP00000256474 | kinesin family member 3A; Microtubule-based anterograde translocator for membranous organelles. Plus end-directed microtubule sliding activity in vitro. Plays a role in primary cilia formation (By similarity) | von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase; Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 | 0.633 |
MAP1LC3A | NEK1 | ENSP00000363970 | ENSP00000424757 | microtubule-associated protein 1 light chain 3 alpha; Involved in formation of autophagosomal vacuoles (autophagosomes) | NIMA-related kinase 1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly | 0.665 |
NEK1 | ATRX | ENSP00000424757 | ENSP00000362441 | NIMA-related kinase 1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly | alpha thalassemia/mental retardation syndrome X-linked | 0.657 |
NEK1 | DYNC2H1 | ENSP00000424757 | ENSP00000381167 | NIMA-related kinase 1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly | dynein, cytoplasmic 2, heavy chain 1 | 0.888 |
NEK1 | FEZ1 | ENSP00000424757 | ENSP00000278919 | NIMA-related kinase 1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly | fasciculation and elongation protein zeta 1 (zygin I); May be involved in axonal outgrowth as component of the network of molecules that regulate cellular morphology and axon guidance machinery. Able to restore partial locomotion and axonal fasciculation to C.elegans unc-76 mutants in germline transformation experiments. May participate in the transport of mitochondria and other cargos along microtubules | 0.682 |
NEK1 | FEZ2 | ENSP00000424757 | ENSP00000368547 | NIMA-related kinase 1; Phosphorylates serines and threonines, but also appears to possess tyrosine kinase activity. Implicated in the control of meiosis (By similarity). Involved in cilium assembly | fasciculation and elongation protein zeta 2 (zygin II); Involved in axonal outgrowth and fasciculation (By similarity) | 0.693 |