Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | SATL1 | spermidine/spermine N1-acetyl transferase-like 1 (632 aa) | ||||||||||||
Predicted Functional Partners:
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 | OMA1 | OMA1 zinc metallopeptidase homolog (S. cerevisiae); Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Its role in mitochondrial quality control is essential for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress conditions (524 aa) |
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0.519 | ||||||||||
 | ZNF674 | zinc finger protein 674; May be involved in transcriptional regulation (581 aa) |
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0.516 | ||||||||||
 | TGIF2LX | TGFB-induced factor homeobox 2-like, X-linked; May have a transcription role in testis (241 aa) |
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0.515 | ||||||||||
 | CPXCR1 | CPX chromosome region, candidate 1 (301 aa) |
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0.508 | ||||||||||
 | PABPC5 | poly(A) binding protein, cytoplasmic 5; Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo (By similarity) (382 aa) |
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0.502 | ||||||||||
 | PCDH11X | protocadherin 11 X-linked (1347 aa) |
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0.472 | ||||||||||
 | RPA4 | replication protein A4, 30kDa; Functions as component of the alternative replication protein A complex (aRPA). aRPA binds single-stranded DNA and probably plays a role in DNA repair; it does not support chromosomal DNA replication and cell cycle progression through S- phase. In vitro, aRPA cannot promote efficient priming by DNA polymerase alpha but supports DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the dual incision/excision reaction of nucleotide excision repair and RAD51-dependent strand exchange (261 aa) |
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0.472 | ||||||||||
 | POF1B | premature ovarian failure, 1B; May be involved in ovary development (589 aa) |
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0.472 | ||||||||||
 | SPATA20 | spermatogenesis associated 20; May play a role in fertility regulation (By similarity) (802 aa) |
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0.450 | ||||||||||
 | ANAPC5 | anaphase promoting complex subunit 5; Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins- it mainly mediates the formation of ’Lys-11’-linked polyubiquitin chains and, to a lower extent, the formation of ’Lys-48’- and ’Lys-63’-linked polyubiquitin chains (755 aa) |
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0.445 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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