node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACOX1 | PALLD | ENSP00000293217 | ENSP00000425556 | acyl-CoA oxidase 1, palmitoyl | palladin, cytoskeletal associated protein | 0.644 |
ACOX1 | UBC | ENSP00000293217 | ENSP00000344818 | acyl-CoA oxidase 1, palmitoyl | ubiquitin C | 0.525 |
ACTN1 | DSTN | ENSP00000377941 | ENSP00000246069 | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner | 0.441 |
ACTN1 | EZR | ENSP00000377941 | ENSP00000338934 | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | 0.968 |
ACTN1 | PALLD | ENSP00000377941 | ENSP00000425556 | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | palladin, cytoskeletal associated protein | 0.826 |
ACTN1 | UBC | ENSP00000377941 | ENSP00000344818 | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | ubiquitin C | 0.931 |
DSTN | ACTN1 | ENSP00000246069 | ENSP00000377941 | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.441 |
DSTN | HSP90AA1 | ENSP00000246069 | ENSP00000335153 | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.443 |
DSTN | PALLD | ENSP00000246069 | ENSP00000425556 | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner | palladin, cytoskeletal associated protein | 0.644 |
DSTN | UBC | ENSP00000246069 | ENSP00000344818 | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner | ubiquitin C | 0.969 |
EZR | ACTN1 | ENSP00000338934 | ENSP00000377941 | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.968 |
EZR | PALLD | ENSP00000338934 | ENSP00000425556 | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | palladin, cytoskeletal associated protein | 0.873 |
EZR | UBC | ENSP00000338934 | ENSP00000344818 | ezrin; Probably involved in connections of major cytoskeletal structures to the plasma membrane. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with PLEKHG6, required for normal macropinocytosis | ubiquitin C | 0.990 |
HSP90AA1 | DSTN | ENSP00000335153 | ENSP00000246069 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner | 0.443 |
HSP90AA1 | HSPB1 | ENSP00000335153 | ENSP00000248553 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | heat shock 27kDa protein 1 | 0.988 |
HSP90AA1 | PALLD | ENSP00000335153 | ENSP00000425556 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | palladin, cytoskeletal associated protein | 0.649 |
HSP90AA1 | UBC | ENSP00000335153 | ENSP00000344818 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | ubiquitin C | 0.999 |
HSPB1 | HSP90AA1 | ENSP00000248553 | ENSP00000335153 | heat shock 27kDa protein 1 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.988 |
HSPB1 | PALLD | ENSP00000248553 | ENSP00000425556 | heat shock 27kDa protein 1 | palladin, cytoskeletal associated protein | 0.644 |
HSPB1 | UBC | ENSP00000248553 | ENSP00000344818 | heat shock 27kDa protein 1 | ubiquitin C | 0.998 |