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STRINGSTRING
TARS2 TARS2 FARS2 FARS2 YARS YARS HARS HARS GCN1L1 GCN1L1 AARS AARS UBC UBC EPRS EPRS KARS KARS TARSL2 TARSL2 TARS TARS
"HARS" - histidyl-tRNA synthetase in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
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small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
Node Color
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
HARShistidyl-tRNA synthetase (509 aa)    
Predicted Functional Partners:
TARS
threonyl-tRNA synthetase (723 aa)
 score_image     score_image score_image   score_image   0.976
UBC
ubiquitin C (685 aa)
         score_image       0.938
KARS
lysyl-tRNA synthetase; Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction- the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. When secreted, acts as a signaling molecule that induces immune response through the activation of monocyte/macrophages. Catalyzes the synthesis of diadenosine oligophosphate (Ap4A), a signaling molecule involved in the activation of MITF transcriptional activity. Interacts with HIV-1 virus GAG protein, facilitating the selective packaging of tRNA(3)(Lys), th [...] (625 aa)
       score_image score_image   score_image   0.911
TARS2
threonyl-tRNA synthetase 2, mitochondrial (putative) (718 aa)
 score_image     score_image     score_image   0.896
AARS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction- alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain (By similarity) (968 aa)
 score_image     score_image     score_image   0.873
YARS
tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction- tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) (528 aa)
 score_image     score_image     score_image   0.870
GCN1L1
GCN1 general control of amino-acid synthesis 1-like 1 (yeast) (2671 aa)
       score_image score_image   score_image   0.865
EPRS
glutamyl-prolyl-tRNA synthetase (1512 aa)
 score_image     score_image     score_image   0.857
FARS2
phenylalanyl-tRNA synthetase 2, mitochondrial; Catalyzes direct attachment of p-Tyr (Tyr) to tRNAPhe. Permits also, with a lower efficiency, the attachment of m-Tyr to tRNAPhe, thereby opening the way for delivery of the misacylated tRNA to the ribosome and incorporation of ROS-damaged amino acid into proteins (451 aa)
 score_image     score_image     score_image   0.853
TARSL2
threonyl-tRNA synthetase-like 2 (802 aa)
 score_image     score_image     score_image   0.853
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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