Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | RNF150 | ring finger protein 150 (438 aa) | ||||||||||||
Predicted Functional Partners:
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 | IDNK | idnK, gluconokinase homolog (E. coli) (187 aa) |
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0.506 | ||||||||||
 | RMND5B | required for meiotic nuclear division 5 homolog B (S. cerevisiae) (393 aa) |
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0.491 | |||||||||
 | LONRF2 | LON peptidase N-terminal domain and ring finger 2 (754 aa) |
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0.485 | ||||||||||
 | LONRF3 | LON peptidase N-terminal domain and ring finger 3 (759 aa) |
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0.485 | ||||||||||
 | IRG1 | immunoresponsive 1 homolog (mouse) (481 aa) |
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0.474 | ||||||||||
 | TBC1D8 | TBC1 domain family, member 8 (with GRAM domain); May act as a GTPase-activating protein for Rab family protein(s) (1140 aa) |
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0.459 | ||||||||||
 | POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each ot [...] (1174 aa) |
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0.447 | |||||||||
 | ZNRF2 | zinc and ring finger 2; May play a role in the establishment and maintenance of neuronal transmission and plasticity via its ubiquitin ligase activity. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (242 aa) |
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0.444 | ||||||||||
 | UBE2Z | ubiquitin-conjugating enzyme E2Z; Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity). Specific substrate for UBA6, not charged with ubiquitin by UBE1. May be involved in apoptosis regulation (354 aa) |
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0.440 | |||||||||
 | UBE2U | ubiquitin-conjugating enzyme E2U (putative); Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity) (226 aa) |
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0.429 | |||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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