node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTA1 | MIB2 | ENSP00000355645 | ENSP00000426103 | actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | mindbomb E3 ubiquitin protein ligase 2 | 0.794 |
ACTA1 | UBC | ENSP00000355645 | ENSP00000344818 | actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | ubiquitin C | 0.999 |
ARID1A | MIB2 | ENSP00000320485 | ENSP00000426103 | AT rich interactive domain 1A (SWI-like) | mindbomb E3 ubiquitin protein ligase 2 | 0.930 |
ARID1A | SOX2 | ENSP00000320485 | ENSP00000323588 | AT rich interactive domain 1A (SWI-like) | SRY (sex determining region Y)-box 2; Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity). Critical for early embryogenesis and for embryonic stem cell pluripotency. May function as a switch in neuronal development. Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity). Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiat [...] | 0.588 |
ARID1A | UBC | ENSP00000320485 | ENSP00000344818 | AT rich interactive domain 1A (SWI-like) | ubiquitin C | 0.620 |
BCL10 | MIB2 | ENSP00000271015 | ENSP00000426103 | B-cell CLL/lymphoma 10; Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 | mindbomb E3 ubiquitin protein ligase 2 | 0.918 |
BCL10 | UBC | ENSP00000271015 | ENSP00000344818 | B-cell CLL/lymphoma 10; Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 | ubiquitin C | 0.987 |
EPS15 | MIB2 | ENSP00000360798 | ENSP00000426103 | epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] | mindbomb E3 ubiquitin protein ligase 2 | 0.922 |
EPS15 | UBC | ENSP00000360798 | ENSP00000344818 | epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] | ubiquitin C | 0.999 |
GRIN2B | MIB2 | ENSP00000279593 | ENSP00000426103 | glutamate receptor, ionotropic, N-methyl D-aspartate 2B; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity) | mindbomb E3 ubiquitin protein ligase 2 | 0.913 |
GRIN2B | UBC | ENSP00000279593 | ENSP00000344818 | glutamate receptor, ionotropic, N-methyl D-aspartate 2B; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity) | ubiquitin C | 0.607 |
HIF1AN | MIB2 | ENSP00000299163 | ENSP00000426103 | hypoxia inducible factor 1, alpha subunit inhibitor; Hydroxylates HIF-1 alpha at ’Asp-803’ in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also [...] | mindbomb E3 ubiquitin protein ligase 2 | 0.839 |
HIF1AN | UBC | ENSP00000299163 | ENSP00000344818 | hypoxia inducible factor 1, alpha subunit inhibitor; Hydroxylates HIF-1 alpha at ’Asp-803’ in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300- interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also [...] | ubiquitin C | 0.884 |
JAG2 | MIB2 | ENSP00000328169 | ENSP00000426103 | jagged 2; Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity) | mindbomb E3 ubiquitin protein ligase 2 | 0.950 |
JAG2 | UBC | ENSP00000328169 | ENSP00000344818 | jagged 2; Putative Notch ligand involved in the mediation of Notch signaling. Involved in limb development (By similarity) | ubiquitin C | 0.904 |
MIB2 | ACTA1 | ENSP00000426103 | ENSP00000355645 | mindbomb E3 ubiquitin protein ligase 2 | actin, alpha 1, skeletal muscle; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | 0.794 |
MIB2 | ARID1A | ENSP00000426103 | ENSP00000320485 | mindbomb E3 ubiquitin protein ligase 2 | AT rich interactive domain 1A (SWI-like) | 0.930 |
MIB2 | BCL10 | ENSP00000426103 | ENSP00000271015 | mindbomb E3 ubiquitin protein ligase 2 | B-cell CLL/lymphoma 10; Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1 | 0.918 |
MIB2 | EPS15 | ENSP00000426103 | ENSP00000360798 | mindbomb E3 ubiquitin protein ligase 2 | epidermal growth factor receptor pathway substrate 15; Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta- 1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seem [...] | 0.922 |
MIB2 | GRIN2B | ENSP00000426103 | ENSP00000279593 | mindbomb E3 ubiquitin protein ligase 2 | glutamate receptor, ionotropic, N-methyl D-aspartate 2B; NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity) | 0.913 |