CDKN2AIP protein (Homo sapiens) - STRING network view

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CDKN2AIP

CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways (580 aa)

Predicted Functional Partners:

CDKN2A

0.985

MDM2

0.844

UBC

0.771

OR7C2

0.645

EPHX1

0.644

GGH

0.644

XRN2

0.481

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDKN2A	CDKN2AIP	ENSP00000394932	ENSP00000427108	cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein	CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways	0.985
CDKN2A	MDM2	ENSP00000394932	ENSP00000417281	cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	0.999
CDKN2A	UBC	ENSP00000394932	ENSP00000344818	cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein	ubiquitin C	0.998
CDKN2AIP	CDKN2A	ENSP00000427108	ENSP00000394932	CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways	cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein	0.985
CDKN2AIP	EPHX1	ENSP00000427108	ENSP00000272167	CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways	epoxide hydrolase 1, microsomal (xenobiotic)	0.644
CDKN2AIP	GGH	ENSP00000427108	ENSP00000260118	CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates	0.644
CDKN2AIP	MDM2	ENSP00000427108	ENSP00000417281	CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	0.844
CDKN2AIP	OR7C2	ENSP00000427108	ENSP00000248072	CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways	olfactory receptor, family 7, subfamily C, member 2; Odorant receptor (Potential)	0.645
CDKN2AIP	UBC	ENSP00000427108	ENSP00000344818	CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways	ubiquitin C	0.771
CDKN2AIP	XRN2	ENSP00000427108	ENSP00000366396	CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways	5’-3’ exoribonuclease 2; Possesses 5’->3’ exoribonuclease activity (By similarity). May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5’ fragment which is subsequently processed to form the mature mRNA and a 3’ fragment which remains attached to the elongating polymerase. The processive degradation of this 3’ fragment by this protein may promote termination of transcription	0.481
EPHX1	CDKN2AIP	ENSP00000272167	ENSP00000427108	epoxide hydrolase 1, microsomal (xenobiotic)	CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways	0.644
EPHX1	UBC	ENSP00000272167	ENSP00000344818	epoxide hydrolase 1, microsomal (xenobiotic)	ubiquitin C	0.817
GGH	CDKN2AIP	ENSP00000260118	ENSP00000427108	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates	CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways	0.644
GGH	UBC	ENSP00000260118	ENSP00000344818	gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase); Hydrolyzes the polyglutamate sidechains of pteroylpolyglutamates. Progressively removes gamma-glutamyl residues from pteroylpoly-gamma-glutamate to yield pteroyl-alpha- glutamate (folic acid) and free glutamate. May play an important role in the bioavailability of dietary pteroylpolyglutamates and in the metabolism of pteroylpolyglutamates and antifolates	ubiquitin C	0.721
MDM2	CDKN2A	ENSP00000417281	ENSP00000394932	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein	0.999
MDM2	CDKN2AIP	ENSP00000417281	ENSP00000427108	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways	0.844
MDM2	UBC	ENSP00000417281	ENSP00000344818	Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse)	ubiquitin C	0.999
OR7C2	CDKN2AIP	ENSP00000248072	ENSP00000427108	olfactory receptor, family 7, subfamily C, member 2; Odorant receptor (Potential)	CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways	0.645
UBC	CDKN2A	ENSP00000344818	ENSP00000394932	ubiquitin C	cyclin-dependent kinase inhibitor 2A; Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein	0.998
UBC	CDKN2AIP	ENSP00000344818	ENSP00000427108	ubiquitin C	CDKN2A interacting protein; Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways	0.771

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