node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ALX4 | FOXR2 | ENSP00000332744 | ENSP00000427329 | ALX homeobox 4; Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development | forkhead box R2 | 0.495 |
BCL9L | FOXR2 | ENSP00000335320 | ENSP00000427329 | B-cell CLL/lymphoma 9-like; Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity) | forkhead box R2 | 0.541 |
BCL9L | MFRP | ENSP00000335320 | ENSP00000391664 | B-cell CLL/lymphoma 9-like; Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity) | membrane frizzled-related protein | 0.532 |
BCL9L | RD6 | ENSP00000335320 | ENSP00000456533 | B-cell CLL/lymphoma 9-like; Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity) | Membrane frizzled-related protein ; May play a role in eye development | 0.584 |
CLCN5 | FAM123B | ENSP00000365256 | ENSP00000329117 | chloride channel, voltage-sensitive 5; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function | family with sequence similarity 123B; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context- acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta- ca [...] | 0.446 |
CLCN5 | FOXR2 | ENSP00000365256 | ENSP00000427329 | chloride channel, voltage-sensitive 5; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function | forkhead box R2 | 0.569 |
FAM123B | CLCN5 | ENSP00000329117 | ENSP00000365256 | family with sequence similarity 123B; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context- acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta- ca [...] | chloride channel, voltage-sensitive 5; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function | 0.446 |
FAM123B | FOXR2 | ENSP00000329117 | ENSP00000427329 | family with sequence similarity 123B; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context- acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta- ca [...] | forkhead box R2 | 0.485 |
FOXR2 | ALX4 | ENSP00000427329 | ENSP00000332744 | forkhead box R2 | ALX homeobox 4; Transcription factor involved in skull and limb development. Plays an essential role in craniofacial development, skin and hair follicle development | 0.495 |
FOXR2 | BCL9L | ENSP00000427329 | ENSP00000335320 | forkhead box R2 | B-cell CLL/lymphoma 9-like; Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity) | 0.541 |
FOXR2 | CLCN5 | ENSP00000427329 | ENSP00000365256 | forkhead box R2 | chloride channel, voltage-sensitive 5; Proton-coupled chloride transporter. Functions as antiport system and exchanges chloride ions against protons. Important for normal acidification of the endosome lumen. May play an important role in renal tubular function | 0.569 |
FOXR2 | FAM123B | ENSP00000427329 | ENSP00000329117 | forkhead box R2 | family with sequence similarity 123B; Regulator of the canonical Wnt signaling pathway. Acts by specifically binding phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), translocating to the cell membrane and interacting with key regulators of the canonical Wnt signaling pathway, such as components of the beta-catenin destruction complex. Acts both as a positive and negative regulator of the Wnt signaling pathway, depending on the context- acts as a positive regulator by promoting LRP6 phosphorylation. Also acts as a negative regulator by acting as a scaffold protein for the beta- ca [...] | 0.485 |
FOXR2 | FRMD7 | ENSP00000427329 | ENSP00000298542 | forkhead box R2 | FERM domain containing 7; Plays a role in neurite development (By similarity). May play a specific role in the control of eye movement and gaze stability | 0.571 |
FOXR2 | MFRP | ENSP00000427329 | ENSP00000391664 | forkhead box R2 | membrane frizzled-related protein | 0.486 |
FOXR2 | PEF1 | ENSP00000427329 | ENSP00000362807 | forkhead box R2 | penta-EF-hand domain containing 1 | 0.571 |
FOXR2 | RD6 | ENSP00000427329 | ENSP00000456533 | forkhead box R2 | Membrane frizzled-related protein ; May play a role in eye development | 0.537 |
FOXR2 | SIRT1 | ENSP00000427329 | ENSP00000212015 | forkhead box R2 | sirtuin 1; NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively. Se [...] | 0.517 |
FOXR2 | SIRT5 | ENSP00000427329 | ENSP00000368552 | forkhead box R2 | sirtuin 5; NAD-dependent lysine demalonylase and desuccinylase that specifically removes malonyl and succinyl groups on target proteins. Activates CPS1 and contributes to the regulation of blood ammonia levels during prolonged fasting- acts by mediating desuccinylation of CPS1, thereby increasing CPS1 activity in response to elevated NAD levels during fasting. Has weak NAD- dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo. Can deacetylate cytochrome c (CYCS) and a number of other proteins in vitro | 0.517 |
FRMD7 | FOXR2 | ENSP00000298542 | ENSP00000427329 | FERM domain containing 7; Plays a role in neurite development (By similarity). May play a specific role in the control of eye movement and gaze stability | forkhead box R2 | 0.571 |
MFRP | BCL9L | ENSP00000391664 | ENSP00000335320 | membrane frizzled-related protein | B-cell CLL/lymphoma 9-like; Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1 (By similarity) | 0.532 |