NACA2 protein (Homo sapiens) - STRING network view

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NACA2

nascent polypeptide-associated complex alpha subunit 2; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene [...] (215 aa)

Predicted Functional Partners:

BTF3L4

0.990

BTF3

0.984

RPL32

0.902

NPSR1

0.891

RPL35

0.887

RPL7L1

0.880

RPL7

0.880

NACA

0.876

RPL23

0.862

RPL13A

0.852

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BTF3	NACA	ENSP00000369965	ENSP00000448035	basic transcription factor 3; General transcription factor. BTF3 can form a stable complex with RNA polymerase II. Required for the initiation of transcription	nascent polypeptide-associated complex alpha subunit; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene pr [...]	0.997
BTF3	NACA2	ENSP00000369965	ENSP00000427802	basic transcription factor 3; General transcription factor. BTF3 can form a stable complex with RNA polymerase II. Required for the initiation of transcription	nascent polypeptide-associated complex alpha subunit 2; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene [...]	0.984
BTF3	NPSR1	ENSP00000369965	ENSP00000352839	basic transcription factor 3; General transcription factor. BTF3 can form a stable complex with RNA polymerase II. Required for the initiation of transcription	neuropeptide S receptor 1	0.485
BTF3	RPL13A	ENSP00000369965	ENSP00000375730	basic transcription factor 3; General transcription factor. BTF3 can form a stable complex with RNA polymerase II. Required for the initiation of transcription	ribosomal protein L13a; Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3’-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses [...]	0.436
BTF3	RPL23	ENSP00000369965	ENSP00000377865	basic transcription factor 3; General transcription factor. BTF3 can form a stable complex with RNA polymerase II. Required for the initiation of transcription	ribosomal protein L23	0.492
BTF3	RPL32	ENSP00000369965	ENSP00000380156	basic transcription factor 3; General transcription factor. BTF3 can form a stable complex with RNA polymerase II. Required for the initiation of transcription	ribosomal protein L32	0.748
BTF3	RPL35	ENSP00000369965	ENSP00000259469	basic transcription factor 3; General transcription factor. BTF3 can form a stable complex with RNA polymerase II. Required for the initiation of transcription	ribosomal protein L35	0.618
BTF3	RPL7	ENSP00000369965	ENSP00000339795	basic transcription factor 3; General transcription factor. BTF3 can form a stable complex with RNA polymerase II. Required for the initiation of transcription	ribosomal protein L7; Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs	0.491
BTF3	RPL7L1	ENSP00000369965	ENSP00000346063	basic transcription factor 3; General transcription factor. BTF3 can form a stable complex with RNA polymerase II. Required for the initiation of transcription	ribosomal protein L7-like 1	0.485
BTF3L4	NACA	ENSP00000360664	ENSP00000448035	basic transcription factor 3-like 4	nascent polypeptide-associated complex alpha subunit; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene pr [...]	0.974
BTF3L4	NACA2	ENSP00000360664	ENSP00000427802	basic transcription factor 3-like 4	nascent polypeptide-associated complex alpha subunit 2; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene [...]	0.990
BTF3L4	NPSR1	ENSP00000360664	ENSP00000352839	basic transcription factor 3-like 4	neuropeptide S receptor 1	0.485
BTF3L4	RPL13A	ENSP00000360664	ENSP00000375730	basic transcription factor 3-like 4	ribosomal protein L13a; Associated with ribosomes but is not required for canonical ribosome function and has extra-ribosomal functions. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. Upon interferon-gamma activation and subsequent phosphorylation dissociates from the ribosome and assembles into the GAIT complex which binds to stem loop-containing GAIT elements in the 3’-UTR of diverse inflammatory mRNAs (such as ceruplasmin) and suppresses [...]	0.429
BTF3L4	RPL23	ENSP00000360664	ENSP00000377865	basic transcription factor 3-like 4	ribosomal protein L23	0.433
BTF3L4	RPL32	ENSP00000360664	ENSP00000380156	basic transcription factor 3-like 4	ribosomal protein L32	0.716
BTF3L4	RPL35	ENSP00000360664	ENSP00000259469	basic transcription factor 3-like 4	ribosomal protein L35	0.652
BTF3L4	RPL7	ENSP00000360664	ENSP00000339795	basic transcription factor 3-like 4	ribosomal protein L7; Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs	0.485
BTF3L4	RPL7L1	ENSP00000360664	ENSP00000346063	basic transcription factor 3-like 4	ribosomal protein L7-like 1	0.485
NACA	BTF3	ENSP00000448035	ENSP00000369965	nascent polypeptide-associated complex alpha subunit; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene pr [...]	basic transcription factor 3; General transcription factor. BTF3 can form a stable complex with RNA polymerase II. Required for the initiation of transcription	0.997
NACA	BTF3L4	ENSP00000448035	ENSP00000360664	nascent polypeptide-associated complex alpha subunit; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites). May act as a specific coactivator for JUN, binding to DNA and stabilizing the interaction of JUN homodimers with target gene pr [...]	basic transcription factor 3-like 4	0.974

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