node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C8orf34 | CDK2AP1 | ENSP00000427820 | ENSP00000261692 | chromosome 8 open reading frame 34 | cyclin-dependent kinase 2 associated protein 1; specific inhibitor of the cell-cycle kinase CDK2 (By similarity) | 0.532 |
C8orf34 | CLVS1 | ENSP00000427820 | ENSP00000325506 | chromosome 8 open reading frame 34 | clavesin 1; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) | 0.535 |
C8orf34 | MAPK4 | ENSP00000427820 | ENSP00000383234 | chromosome 8 open reading frame 34 | mitogen-activated protein kinase 4 | 0.560 |
C8orf34 | MCM7 | ENSP00000427820 | ENSP00000307288 | chromosome 8 open reading frame 34 | minichromosome maintenance complex component 7; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute dif [...] | 0.537 |
C8orf34 | MTFR1 | ENSP00000427820 | ENSP00000262146 | chromosome 8 open reading frame 34 | mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity) | 0.470 |
C8orf34 | NKAIN3 | ENSP00000427820 | ENSP00000333627 | chromosome 8 open reading frame 34 | Na+/K+ transporting ATPase interacting 3 | 0.655 |
C8orf34 | PREX2 | ENSP00000427820 | ENSP00000288368 | chromosome 8 open reading frame 34 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2; Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein- coupled receptors and phosphoinositide 3-kinase | 0.412 |
C8orf34 | ST18 | ENSP00000427820 | ENSP00000276480 | chromosome 8 open reading frame 34 | suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein); Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5’-AAAGTTT-3’ separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells | 0.524 |
CDK2AP1 | C8orf34 | ENSP00000261692 | ENSP00000427820 | cyclin-dependent kinase 2 associated protein 1; specific inhibitor of the cell-cycle kinase CDK2 (By similarity) | chromosome 8 open reading frame 34 | 0.532 |
CDK2AP1 | ST18 | ENSP00000261692 | ENSP00000276480 | cyclin-dependent kinase 2 associated protein 1; specific inhibitor of the cell-cycle kinase CDK2 (By similarity) | suppression of tumorigenicity 18 (breast carcinoma) (zinc finger protein); Repressor that binds to DNA sequences containing a bipartite element consisting of a direct repeat of the sequence 5’-AAAGTTT-3’ separated by 2-9 nucleotides. Represses basal transcription activity from target promoters (By similarity). Inhibits colony formation in cultured breast cancer cells | 0.810 |
CLVS1 | C8orf34 | ENSP00000325506 | ENSP00000427820 | clavesin 1; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) | chromosome 8 open reading frame 34 | 0.535 |
CLVS1 | NKAIN3 | ENSP00000325506 | ENSP00000333627 | clavesin 1; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) | Na+/K+ transporting ATPase interacting 3 | 0.568 |
MAPK4 | C8orf34 | ENSP00000383234 | ENSP00000427820 | mitogen-activated protein kinase 4 | chromosome 8 open reading frame 34 | 0.560 |
MCM7 | C8orf34 | ENSP00000307288 | ENSP00000427820 | minichromosome maintenance complex component 7; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for ’once per cell cycle’ DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute dif [...] | chromosome 8 open reading frame 34 | 0.537 |
MTFR1 | C8orf34 | ENSP00000262146 | ENSP00000427820 | mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity) | chromosome 8 open reading frame 34 | 0.470 |
MTFR1 | NKAIN3 | ENSP00000262146 | ENSP00000333627 | mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity) | Na+/K+ transporting ATPase interacting 3 | 0.501 |
NKAIN3 | C8orf34 | ENSP00000333627 | ENSP00000427820 | Na+/K+ transporting ATPase interacting 3 | chromosome 8 open reading frame 34 | 0.655 |
NKAIN3 | CLVS1 | ENSP00000333627 | ENSP00000325506 | Na+/K+ transporting ATPase interacting 3 | clavesin 1; Required for normal morphology of late endosomes and/or lysosomes in neurons (By similarity). Binds phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) | 0.568 |
NKAIN3 | MTFR1 | ENSP00000333627 | ENSP00000262146 | Na+/K+ transporting ATPase interacting 3 | mitochondrial fission regulator 1; May play a role in mitochondrial aerobic respiration. May also regulate mitochondrial organization and fission (By similarity) | 0.501 |
NKAIN3 | PREX2 | ENSP00000333627 | ENSP00000288368 | Na+/K+ transporting ATPase interacting 3 | phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2; Functions as a RAC1 guanine nucleotide exchange factor (GEF), activating Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. Mediates the activation of RAC1 in a PI3K-dependent manner. May be an important mediator of Rac signaling, acting directly downstream of both G protein- coupled receptors and phosphoinositide 3-kinase | 0.459 |