IRGM protein (Homo sapiens) - STRING network view

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IRGM

immunity-related GTPase family, M; Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity) (181 aa)

Predicted Functional Partners:

ATG16L1

0.824

ZNF300

0.754

NOD2

0.725

NKX2-3

0.658

TSPAN8

0.629

IL23R

0.563

PTPN2

0.563

TNFSF15

0.532

DLG5

0.506

CARD9

0.505

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATG16L1	DLG5	ENSP00000375872	ENSP00000361467	autophagy related 16-like 1 (S. cerevisiae)	discs, large homolog 5 (Drosophila)	0.623
ATG16L1	IL23R	ENSP00000375872	ENSP00000321345	autophagy related 16-like 1 (S. cerevisiae)	interleukin 23 receptor	0.720
ATG16L1	IRGM	ENSP00000375872	ENSP00000428220	autophagy related 16-like 1 (S. cerevisiae)	immunity-related GTPase family, M; Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity)	0.824
ATG16L1	NKX2-3	ENSP00000375872	ENSP00000342828	autophagy related 16-like 1 (S. cerevisiae)	NK2 homeobox 3; Transcription factor (By similarity)	0.585
ATG16L1	NOD2	ENSP00000375872	ENSP00000300589	autophagy related 16-like 1 (S. cerevisiae)	nucleotide-binding oligomerization domain containing 2; Induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK- gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS)	0.986
ATG16L1	PTPN2	ENSP00000375872	ENSP00000311857	autophagy related 16-like 1 (S. cerevisiae)	protein tyrosine phosphatase, non-receptor type 2	0.470
ATG16L1	TNFSF15	ENSP00000375872	ENSP00000363157	autophagy related 16-like 1 (S. cerevisiae)	tumor necrosis factor (ligand) superfamily, member 15; Receptor for TNFRSF25 and TNFRSF6B. Mediates activation of NF-kappa-B. Inhibits vascular endothelial growth and angiogenesis (in vitro). Promotes activation of caspases and apoptosis	0.504
CARD9	IRGM	ENSP00000360797	ENSP00000428220	caspase recruitment domain family, member 9; Activates NF-kappa-B via BCL10	immunity-related GTPase family, M; Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity)	0.505
CARD9	NOD2	ENSP00000360797	ENSP00000300589	caspase recruitment domain family, member 9; Activates NF-kappa-B via BCL10	nucleotide-binding oligomerization domain containing 2; Induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK- gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS)	0.472
DLG5	ATG16L1	ENSP00000361467	ENSP00000375872	discs, large homolog 5 (Drosophila)	autophagy related 16-like 1 (S. cerevisiae)	0.623
DLG5	IL23R	ENSP00000361467	ENSP00000321345	discs, large homolog 5 (Drosophila)	interleukin 23 receptor	0.502
DLG5	IRGM	ENSP00000361467	ENSP00000428220	discs, large homolog 5 (Drosophila)	immunity-related GTPase family, M; Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity)	0.506
DLG5	NKX2-3	ENSP00000361467	ENSP00000342828	discs, large homolog 5 (Drosophila)	NK2 homeobox 3; Transcription factor (By similarity)	0.606
DLG5	NOD2	ENSP00000361467	ENSP00000300589	discs, large homolog 5 (Drosophila)	nucleotide-binding oligomerization domain containing 2; Induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK- gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS)	0.725
IL23R	ATG16L1	ENSP00000321345	ENSP00000375872	interleukin 23 receptor	autophagy related 16-like 1 (S. cerevisiae)	0.720
IL23R	DLG5	ENSP00000321345	ENSP00000361467	interleukin 23 receptor	discs, large homolog 5 (Drosophila)	0.502
IL23R	IRGM	ENSP00000321345	ENSP00000428220	interleukin 23 receptor	immunity-related GTPase family, M; Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity)	0.563
IL23R	NKX2-3	ENSP00000321345	ENSP00000342828	interleukin 23 receptor	NK2 homeobox 3; Transcription factor (By similarity)	0.459
IL23R	NOD2	ENSP00000321345	ENSP00000300589	interleukin 23 receptor	nucleotide-binding oligomerization domain containing 2; Induces NF-kappa-B via RICK (CARDIAK, RIP2) and IKK- gamma. Confers responsiveness to intracellular bacterial lipopolysaccharides (LPS)	0.659
IRGM	ATG16L1	ENSP00000428220	ENSP00000375872	immunity-related GTPase family, M; Putative GTPase which is required for clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. May also play a role in macrophages adhesion and motility (By similarity)	autophagy related 16-like 1 (S. cerevisiae)	0.824

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