SERPINE3 protein (Homo sapiens) - STRING network view

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Score

SERPINE3

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3; Probable serine protease inhibitor (By similarity) (424 aa)

Predicted Functional Partners:

CCM2

0.508

HMSD

0.495

EDF1

0.414

PITRM1

0.408

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCM2	SERPINE3	ENSP00000370503	ENSP00000428316	cerebral cavernous malformation 2; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3- dependent p38 activation induced by hyperosmotic shock (By similarity)	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3; Probable serine protease inhibitor (By similarity)	0.508
EDF1	HMSD	ENSP00000224073	ENSP00000386207	endothelial differentiation-related factor 1; Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism	histocompatibility (minor) serpin domain containing; Putative serine protease inhibitor (By similarity)	0.414
EDF1	SERPINE3	ENSP00000224073	ENSP00000428316	endothelial differentiation-related factor 1; Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3; Probable serine protease inhibitor (By similarity)	0.414
HMSD	EDF1	ENSP00000386207	ENSP00000224073	histocompatibility (minor) serpin domain containing; Putative serine protease inhibitor (By similarity)	endothelial differentiation-related factor 1; Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism	0.414
HMSD	PITRM1	ENSP00000386207	ENSP00000370377	histocompatibility (minor) serpin domain containing; Putative serine protease inhibitor (By similarity)	pitrilysin metallopeptidase 1	0.408
HMSD	SERPINE3	ENSP00000386207	ENSP00000428316	histocompatibility (minor) serpin domain containing; Putative serine protease inhibitor (By similarity)	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3; Probable serine protease inhibitor (By similarity)	0.495
PITRM1	HMSD	ENSP00000370377	ENSP00000386207	pitrilysin metallopeptidase 1	histocompatibility (minor) serpin domain containing; Putative serine protease inhibitor (By similarity)	0.408
PITRM1	SERPINE3	ENSP00000370377	ENSP00000428316	pitrilysin metallopeptidase 1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3; Probable serine protease inhibitor (By similarity)	0.408
SERPINE3	CCM2	ENSP00000428316	ENSP00000370503	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3; Probable serine protease inhibitor (By similarity)	cerebral cavernous malformation 2; Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3- dependent p38 activation induced by hyperosmotic shock (By similarity)	0.508
SERPINE3	EDF1	ENSP00000428316	ENSP00000224073	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3; Probable serine protease inhibitor (By similarity)	endothelial differentiation-related factor 1; Transcriptional coactivator stimulating NR5A1 and ligand-dependent NR1H3/LXRA and PPARG transcriptional activities. Enhances the DNA-binding activity of ATF1, ATF2, CREB1 and NR5A1. Regulates nitric oxid synthase activity probably by sequestering calmodulin in the cytoplasm. May function in endothelial cells differentiation, hormone-induced cardiomyocytes hypertrophy and lipid metabolism	0.414
SERPINE3	HMSD	ENSP00000428316	ENSP00000386207	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3; Probable serine protease inhibitor (By similarity)	histocompatibility (minor) serpin domain containing; Putative serine protease inhibitor (By similarity)	0.495
SERPINE3	PITRM1	ENSP00000428316	ENSP00000370377	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 3; Probable serine protease inhibitor (By similarity)	pitrilysin metallopeptidase 1	0.408

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