CES5A protein (Homo sapiens) - STRING network view

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CES5A

carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity) (604 aa)

Predicted Functional Partners:

CES4A

0.911

CES1

0.908

CES3

0.908

CES2

0.906

TFDP2

0.900

TFDP1

0.900

E2F1

0.900

ESD

0.754

HAGH

0.751

ADH5

0.745

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADH5	CES1	ENSP00000296412	ENSP00000353720	alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione	carboxylesterase 1; Has no esterase activity (Probable)	0.582
ADH5	CES5A	ENSP00000296412	ENSP00000428864	alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione	carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity)	0.745
ADH5	ESD	ENSP00000296412	ENSP00000367992	alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione	esterase D; Serine hydrolase involved in the detoxification of formaldehyde	0.989
ADH5	HAGH	ENSP00000296412	ENSP00000380514	alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione	hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	0.540
CES1	ADH5	ENSP00000353720	ENSP00000296412	carboxylesterase 1; Has no esterase activity (Probable)	alcohol dehydrogenase 5 (class III), chi polypeptide; Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione	0.582
CES1	CES2	ENSP00000353720	ENSP00000317842	carboxylesterase 1; Has no esterase activity (Probable)	carboxylesterase 2; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine	0.959
CES1	CES3	ENSP00000353720	ENSP00000304782	carboxylesterase 1; Has no esterase activity (Probable)	carboxylesterase 3; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics	0.910
CES1	CES4A	ENSP00000353720	ENSP00000444052	carboxylesterase 1; Has no esterase activity (Probable)	carboxylesterase 4A; Probable carboxylesterase (By similarity)	0.908
CES1	CES5A	ENSP00000353720	ENSP00000428864	carboxylesterase 1; Has no esterase activity (Probable)	carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity)	0.908
CES1	E2F1	ENSP00000353720	ENSP00000345571	carboxylesterase 1; Has no esterase activity (Probable)	E2F transcription factor 1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis	0.900
CES1	ESD	ENSP00000353720	ENSP00000367992	carboxylesterase 1; Has no esterase activity (Probable)	esterase D; Serine hydrolase involved in the detoxification of formaldehyde	0.645
CES1	HAGH	ENSP00000353720	ENSP00000380514	carboxylesterase 1; Has no esterase activity (Probable)	hydroxyacylglutathione hydrolase; Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid	0.590
CES1	TFDP1	ENSP00000353720	ENSP00000364519	carboxylesterase 1; Has no esterase activity (Probable)	transcription factor Dp-1; Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5’-TTTC[CG]CGC-3’, found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DP2/E2F complex functions in the control of cell-cycle progression from G1 to S phase. The E2F1/DP complex appears to mediate both cell proliferation and apoptosis	0.900
CES1	TFDP2	ENSP00000353720	ENSP00000420616	carboxylesterase 1; Has no esterase activity (Probable)	transcription factor Dp-2 (E2F dimerization partner 2)	0.900
CES2	CES1	ENSP00000317842	ENSP00000353720	carboxylesterase 2; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine	carboxylesterase 1; Has no esterase activity (Probable)	0.959
CES2	CES3	ENSP00000317842	ENSP00000304782	carboxylesterase 2; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine	carboxylesterase 3; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics	0.909
CES2	CES4A	ENSP00000317842	ENSP00000444052	carboxylesterase 2; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine	carboxylesterase 4A; Probable carboxylesterase (By similarity)	0.908
CES2	CES5A	ENSP00000317842	ENSP00000428864	carboxylesterase 2; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine	carboxylesterase 5A; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity)	0.906
CES2	E2F1	ENSP00000317842	ENSP00000345571	carboxylesterase 2; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine	E2F transcription factor 1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis	0.900
CES2	ESD	ENSP00000317842	ENSP00000367992	carboxylesterase 2; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine	esterase D; Serine hydrolase involved in the detoxification of formaldehyde	0.499

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