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STRINGSTRING
CHGA CHGA RGS6 RGS6 SEC24A SEC24A MAPK8 MAPK8 STMN2 STMN2 TRPC5 TRPC5 UBC UBC SRC SRC RND1 RND1 SULT1A1 SULT1A1 PPM1G PPM1G
"STMN2" - stathmin-like 2 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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STMN2stathmin-like 2; Regulator of microtubule stability. When phosphorylated by MAPK8, stabilizes microtubules and consequently controls neurite length in cortical neurons. In the developing brain, negatively regulates the rate of exit from multipolar stage and retards radial migration from the ventricular zone (By similarity) (187 aa)    
Predicted Functional Partners:
RGS6
regulator of G-protein signaling 6 (490 aa)
        score_image   score_image   0.920
PPM1G
protein phosphatase, Mg2+/Mn2+ dependent, 1G (546 aa)
        score_image       0.918
SULT1A1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1; Sulfotransferase that utilizes 3’-phospho-5’-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N- hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk (295 aa)
        score_image   score_image   0.904
SEC24A
SEC24 family, member A (S. cerevisiae); Component of the COPII coat, that covers ER-derived vesicles involved in transport from the endoplasmic reticulum to the Golgi apparatus. COPII acts in the cytoplasm to promote the transport of secretory, plasma membrane, and vacuolar proteins from the endoplasmic reticulum to the Golgi complex (1093 aa)
        score_image       0.902
UBC
ubiquitin C (685 aa)
        score_image       0.892
TRPC5
transient receptor potential cation channel, subfamily C, member 5; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Has also been shown to be calcium-selective (By similarity). May also be activated by intracellular calcium store depletion (973 aa)
        score_image   score_image   0.849
CHGA
chromogranin A (parathyroid secretory protein 1); Pancreastatin strongly inhibits glucose induced insulin release from the pancreas (457 aa)
      score_image     score_image   0.816
MAPK8
mitogen-activated protein kinase 8; Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JU [...] (427 aa)
            score_image   0.802
RND1
Rho family GTPase 1; Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments (232 aa)
            score_image   0.801
SRC
v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian); Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein- coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to f [...] (536 aa)
            score_image   0.800
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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